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SR-A, MARCO and TLR...
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Pluddemann, A
(författare)
SR-A, MARCO and TLRs differentially recognise selected surface proteins from Neisseria meningitidis: an example of fine specificity in microbial ligand recognition by innate immune receptors
- Artikel/kapitelEngelska2009
Förlag, utgivningsår, omfång ...
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2008-09-11
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S. Karger AG,2009
Nummerbeteckningar
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:119094374
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http://kipublications.ki.se/Default.aspx?queryparsed=id:119094374URI
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https://doi.org/10.1159/000155227DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Macrophages express various classes of pattern recognition receptors involved in innate immune recognition of artificial, microbial and host-derived ligands. These include the scavenger receptors (SRs), which are important for phagocytosis, and the Toll-like receptors (TLRs) involved in microbe sensing. The class A macrophage scavenger receptor (SR-A) and macrophage receptor with a collagenous structure (MARCO) display similar domain structures and ligand-binding specificity, which has led to the assumption that these two receptors may be functionally redundant. In this study we show that SR-A and MARCO differentially recognise artificial polyanionic ligands as well as surface proteins from the pathogenic bacterium <i>Neisseria meningitidis</i>. We show that, while acetylated low-density lipoprotein (AcLDL) is a strong ligand for SR-A, it is not a ligand for MARCO. Of the neisserial proteins that were SR ligands, some were ligands for both receptors, while other proteins were only recognised by either SR-A or MARCO. We also analysed the potential of these ligands to act as TLR agonists and assessed the requirement for SR-A and MARCO in pro-inflammatory cytokine induction. SR ligation alone did not induce cytokine production; however, for proteins that were both SR and TLR ligands, the SRs were required for full activation of TLR pathways.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Mukhopadhyay, S
(författare)
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Sankala, M
(författare)
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Savino, S
(författare)
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Pizza, M
(författare)
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Rappuoli, R
(författare)
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Tryggvason, KKarolinska Institutet
(författare)
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Gordon, S
(författare)
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Karolinska Institutet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of innate immunity: S. Karger AG1:2, s. 153-1631662-81281662-811X
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