APOE ε2 allele is associated with larger regional cortical thicknesses and volumes

• <i>Background:</i> The protective effect of the apolipoprotein E (APOE) &#917;2 allele against Alzheimer’s disease (AD) is controversial. <i>Objective:</i> Our purpose was to clarify if the &#917;2 allele affects regional cortical thicknesses and volumes. <i>Methods:</i> Regional cortical thicknesses and volumes were measured with an automated pipeline in 109 subjects with mild cognitive impairment, 114 AD patients and 105 age-matched healthy controls. <i>Results:</i> In the mild cognitive impairment group, the &#917;2 carriers had thicker regional cortices at the transverse temporal cortex and parahippocampal gyrus than the subjects with &#917;3/&#917;3, and a larger cerebral gray matter and smaller lateral ventricles than the &#917;3/&#917;3 and &#917;4 carriers. In the AD group, the &#917;2 carriers had significantly thicker entorhinal and transverse temporal cortices, a larger whole cerebral gray matter, and smaller lateral ventricles than the subjects with the &#917;3/&#917;3 genotype, and a significantly thicker entorhinal cortex and larger cerebral gray matter than &#917;4 carriers. No APOE2 effect was found in the control group. <i>Conclusion:</i> The APOE &#917;2 allele is associated with larger regional cortical thicknesses and volumes in mild cognitive impairment and AD.

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