WFRF:(Fu JM)
Search: WFRF:(Fu JM) > Umbilical cord bloo...
- 50 of 55
- Previous record
- Next record
- To hitlist
- Sheridan, SD (author)
Umbilical cord blood-derived microglia-like cells to model COVID-19 exposure
- Article/chapterEnglish2021
Publisher, publication year, extent ...
- 2021-03-19
- Springer Science and Business Media LLC,2021
Numbers
- LIBRIS-ID:oai:prod.swepub.kib.ki.se:146102632
- http://kipublications.ki.se/Default.aspx?queryparsed=id:146102632URI
- https://doi.org/10.1038/s41398-021-01287-wDOI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Microglia, the resident brain immune cells, play a critical role in normal brain development, and are impacted by the intrauterine environment, including maternal immune activation and inflammatory exposures. The COVID-19 pandemic presents a potential developmental immune challenge to the fetal brain, in the setting of maternal SARS-CoV-2 infection with its attendant potential for cytokine production and, in severe cases, cytokine storming. There is currently no biomarker or model for in utero microglial priming and function that might aid in identifying the neonates and children most vulnerable to neurodevelopmental morbidity, as microglia remain inaccessible in fetal life and after birth. This study aimed to generate patient-derived microglial-like cell models unique to each neonate from reprogrammed umbilical cord blood mononuclear cells, adapting and extending a novel methodology previously validated for adult peripheral blood mononuclear cells. We demonstrate that umbilical cord blood mononuclear cells can be used to create microglial-like cell models morphologically and functionally similar to microglia observed in vivo. We illustrate the application of this approach by generating microglia from cells exposed and unexposed to maternal SARS-CoV-2 infection. Our ability to create personalized neonatal models of fetal brain immune programming enables non-invasive insights into fetal brain development and potential childhood neurodevelopmental vulnerabilities for a range of maternal exposures, including COVID-19.
Added entries (persons, corporate bodies, meetings, titles ...)
- Thanos, JM (author)
- De Guzman, RM (author)
- McCrea, LT (author)
- Horng, JE (author)
- Fu, T (author)
- Sellgren, CMKarolinska Institutet (author)
- Perlis, RH (author)
- Edlow, AG (author)
- Karolinska Institutet (creator_code:org_t)
Related titles
- In:Translational psychiatry: Springer Science and Business Media LLC11:1, s. 179-2158-3188
Internet link
Find in a library
- Translational psychiatry (Search for host publication in LIBRIS)
To the university's database
- 50 of 55
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Sheridan, SD
- Thanos, JM
- De Guzman, RM
- McCrea, LT
- Horng, JE
- Fu, T
- show more...
- Sellgren, CM
- Perlis, RH
- Edlow, AG
- show less...
- Articles in the publication
- Translational ps ...
- By the university
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
