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  • Carli, VKarolinska Institutet (author)

A protective genetic variant for adverse environments? The role of childhood traumas and serotonin transporter gene on resilience and depressive severity in a high-risk population

  • Article/chapterEnglish2011

Publisher, publication year, extent ...

  • 2020-04-16
  • Cambridge University Press (CUP),2011

Numbers

  • LIBRIS-ID:oai:prod.swepub.kib.ki.se:123617447
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:123617447URI
  • https://doi.org/10.1016/j.eurpsy.2011.04.008DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Genetic aspects may influence the effect of early adverse events on psychological well being in adulthood. In particular, a common polymorphism within the serotonin transporter gene (5-HTTLPR short/long) has been associated to the risk for stress-induced psychopathology. In the present study we investigated the role of childhood traumas and 5-HTTLPR on measures of psychological resilience and depression in a sample of individuals at a high risk for psychological distress (763 male prisoners). The 5-HTTLPR genotype did not influence resilience and depressive severity. However, a significant interaction was observed between 5-HTTLPR and childhood traumas on both resilience and depressive severity. In particular, among subjects exposed to severe childhood trauma only, the long-allele was associated to lower resilience scores and increased current depressive severity as compared to short/short homozygous. Sex specific effects, difference in type and duration of stressors and the specific composition of the sample may explain discrepancy with many studies reporting the short-allele as a vulnerability factor for reactivity to stress. We here speculated that in males the long-allele may confer lower resilience and therefore higher vulnerability for depressive symptoms in subjects exposed to early stress and currently living in stressful environments.

Added entries (persons, corporate bodies, meetings, titles ...)

  • Mandelli, L (author)
  • Zaninotto, L (author)
  • Roy, A (author)
  • Recchia, L (author)
  • Stoppia, L (author)
  • Gatta, V (author)
  • Sarchiapone, M (author)
  • Serretti, A (author)
  • Karolinska Institutet (creator_code:org_t)

Related titles

  • In:European psychiatry : the journal of the Association of European Psychiatrists: Cambridge University Press (CUP)26:8, s. 471-4781778-3585
  • In:European Psychiatry: Cambridge University Press (CUP)26:8, s. 471-4780924-9338

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