Most reported genetic associations with general intelligence are probably false positives

LIBRIS-ID:oai:prod.swepub.kib.ki.se:126194701
http://kipublications.ki.se/Default.aspx?queryparsed=id:126194701URI
https://doi.org/10.1177/0956797611435528DOI
https://research.hhs.se/esploro/outputs/journalArticle/Most-Reported-Genetic-Associations-With-General/991001480476606056URI

General intelligence ( g) and virtually all other behavioral traits are heritable. Associations between g and specific single-nucleotide polymorphisms (SNPs) in several candidate genes involved in brain function have been reported. We sought to replicate published associations between g and 12 specific genetic variants (in the genes DTNBP1, CTSD, DRD2, ANKK1, CHRM2, SSADH, COMT, BDNF, CHRNA4, DISC1, APOE, and SNAP25) using data sets from three independent, well-characterized longitudinal studies with samples of 5,571, 1,759, and 2,441 individuals. Of 32 independent tests across all three data sets, only 1 was nominally significant. By contrast, power analyses showed that we should have expected 10 to 15 significant associations, given reasonable assumptions for genotype effect sizes. For positive controls, we confirmed accepted genetic associations for Alzheimer’s disease and body mass index, and we used SNP-based calculations of genetic relatedness to replicate previous estimates that about half of the variance in g is accounted for by common genetic variation among individuals. We conclude that the molecular genetics of psychology and social science requires approaches that go beyond the examination of candidate genes.

Hebert, BMHarvard University (US) (författare)
Benjamin, DJCornell University (US) (författare)
Beauchamp, JHarvard University (US) (författare)
Cesarini, DMassachusetts Institute of Technology (US) (författare)
van der Loos, MErasmus School of Economics (NL) (författare)
Johannesson, MagnusStockholm School of Economics,Handelshögskolan i Stockholm(Swepub:hhs)198@hhs.se (författare)
Magnusson, PKEKarolinska Institutet,Karolinska Institutet (SE) (författare)
Lichtenstein, PKarolinska Institutet,Karolinska Institutet (SE) (författare)
Atwood, CSUniversity of Wisconsin Milwaukee (US) (författare)
Freese, JNorthwestern University (US) (författare)
Hauser, TSUniversity of Wisconsin Milwaukee (US) (författare)
Hauser, RMUniversity of Wisconsin Milwaukee (US) (författare)
Christakis, NHarvard University (US) (författare)
Laibson, DHarvard University (US) (författare)
Union College (US)Harvard University (US) (creator_code:org_t)

Ingår i:Psychological science: SAGE Publications23:11, s. 1314-13231467-92800956-7976

Av författaren/redakt...: Chabris, CF; Hebert, BM; Benjamin, DJ; Beauchamp, J; Cesarini, D; van der Loos, M; visa fler...; Johannesson, Mag ...; Magnusson, PKE; Lichtenstein, P; Atwood, CS; Freese, J; Hauser, TS; Hauser, RM; Christakis, N; Laibson, D; visa färre...

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