Sökning: L773:2162 4011 OR L773:2162 402X >
Selective lysis of ...
-
Al Agrafi, FaisalHealthy Aging Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh, Kingdom of Saudi Arabia; Department of Medicine Huddinge, Karolinska Institutet, Center for Hematology and Regenerative Medicine, Stockholm, Sweden
(författare)
Selective lysis of acute myeloid leukemia cells by CD34/CD3 bispecific antibody through the activation of γδ T-cells
- Artikel/kapitelEngelska2024
Förlag, utgivningsår, omfång ...
-
Taylor and Francis Ltd.2024
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:kth-351691
-
https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-351691URI
-
https://doi.org/10.1080/2162402X.2024.2379063DOI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:239076247URI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:159136870URI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
QC 20240813
-
Despite the considerable progress in acute myeloid leukemia (AML) treatment, relapse after allogeneic hematopoietic stem cell transplantation (HSCT) is still frequent and associated with a poor prognosis. Relapse has been shown to be correlated with an incomplete eradication of CD34+ leukemic stem cells prior to HSCT. Previously, we have shown that a novel CD34-directed, bispecific T-cell engager (BTE) can efficiently redirect the T-cell effector function toward cancer cells, thus eliminating leukemic cells in vitro and in vivo. However, its impact on γδ T-cells is still unclear. In this study, we tested the efficacy of the CD34-specific BTE using in vitro expanded γδ T-cells as effectors. We showed that the BTEs bind to γδ T-cells and CD34+ leukemic cell lines and induce target cell killing in a dose-dependent manner. Additionally, γδ T-cell mediated killing was found to be superior to αβ T-cell mediated cytotoxicity. Furthermore, we observed that only in the presence of BTE the γδ T-cells induced primary AML blast killing in vitro. Importantly, our results show that γδ T-cells did not target the healthy CD34intermediate endothelial blood–brain barrier cell line (hCMEC/D3) nor lysed CD34+ HSCs from healthy bone marrow samples.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Gaballa, AhmedKarolinska Institutet,Department of Medicine Huddinge, Karolinska Institutet, Center for Hematology and Regenerative Medicine, Stockholm, Sweden; Department of Biochemistry and Molecular Biology, National Liver Institute, Menoufia University, Shebeen El-Kom, Egypt
(författare)
-
Hahn, PaulaDepartment of Medicine Huddinge, Karolinska Institutet, Center for Hematology and Regenerative Medicine, Stockholm, Sweden
(författare)
-
Arruda, Lucas C.M.Department of Medicine Huddinge, Karolinska Institutet, Center for Hematology and Regenerative Medicine, Stockholm, Sweden
(författare)
-
Jaramillo, Adrian C.Department of Medicine Huddinge, Karolinska Institutet, Center for Hematology and Regenerative Medicine, Stockholm, Sweden
(författare)
-
Witsen, MaartjeDepartment of Medicine Huddinge, Karolinska Institutet, Center for Hematology and Regenerative Medicine, Stockholm, Sweden
(författare)
-
Lehmann, SörenDepartment of Medicine Huddinge, Karolinska Institutet, Center for Hematology and Regenerative Medicine, Stockholm, Sweden; Department of Medical Sciences, Hematology, Uppsala University Hospital, Uppsala, Sweden, Uppsala
(författare)
-
Önfelt, BjörnKTH,Science for Life Laboratory, SciLifeLab,Biofysik(Swepub:kth)u1tquq43
(författare)
-
Uhlin, MichaelDepartment of Medicine Huddinge, Karolinska Institutet, Center for Hematology and Regenerative Medicine, Stockholm, Sweden; Department of Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden
(författare)
-
Stikvoort, ArwenDepartment of Medicine Huddinge, Karolinska Institutet, Center for Hematology and Regenerative Medicine, Stockholm, Sweden
(författare)
-
Karolinska InstitutetHealthy Aging Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh, Kingdom of Saudi Arabia; Department of Medicine Huddinge, Karolinska Institutet, Center for Hematology and Regenerative Medicine, Stockholm, Sweden
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Oncoimmunology: Taylor and Francis Ltd.13:12162-40112162-402X
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Al Agrafi, Faisa ...
-
Gaballa, Ahmed
-
Hahn, Paula
-
Arruda, Lucas C. ...
-
Jaramillo, Adria ...
-
Witsen, Maartje
-
visa fler...
-
Lehmann, Sören
-
Önfelt, Björn
-
Uhlin, Michael
-
Stikvoort, Arwen
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Cancer och onkol ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Hematologi
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Immunologi inom ...
- Artiklar i publikationen
-
Oncoimmunology
- Av lärosätet
-
Kungliga Tekniska Högskolan
-
Karolinska Institutet