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Ongoing evolution o...
Ongoing evolution of Chlamydia trachomatis lymphogranuloma venereum : exploring the genomic diversity of circulating strains
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- Seth-Smith, Helena M. B. (författare)
- Univ Basel, Univ Hosp Basel, Clin Bacteriol & Mycol, Basel, Switzerland.;Univ Basel, Dept Biomed, Appl Microbiol Res, Basel, Switzerland.;SIB Swiss Inst Bioinformat, Basel, Switzerland.
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- Benard, Angele (författare)
- Wellcome Trust Sanger Inst, Cambridge, England.;Univ Autonoma Barcelona, VHIR, Healthcare Syst Res Grp, Passeig Vall dHebron 119-129, Barcelona 08035, Spain.
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- Bruisten, Sylvia M. (författare)
- GGD Publ Hlth Serv Amsterdam, Dept Infect Dis, Amsterdam, Netherlands.;Univ Amsterdam, Acad Med Ctr, Amsterdam UMC, Amsterdam Inst Infect & Immun AII, Amsterdam, Netherlands.
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- Versteeg, Bart (författare)
- GGD Publ Hlth Serv Amsterdam, Dept Infect Dis, Amsterdam, Netherlands.;London Sch Hyg & Trop Med, Clin Res Dept, London, England.
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- Herrmann, Björn, 1955- (författare)
- Uppsala universitet,Klinisk mikrobiologi
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- Kok, Jen (författare)
- Univ Sydney, Marie Bashir Inst Infect Dis & Biosecur, Sydney, NSW, Australia.;Univ Sydney, Westmead Clin Sch, Sydney, NSW, Australia.;Westmead Hosp, Inst Clin Pathol & Med Res, Ctr Infect Dis & Microbiol Lab Serv, Westmead, NSW, Australia.
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- Carter, Ian (författare)
- Westmead Hosp, Inst Clin Pathol & Med Res, Ctr Infect Dis & Microbiol Lab Serv, Westmead, NSW, Australia.
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- Peuchant, Olivia (författare)
- CHU Bordeaux, French Natl Reference Ctr Bacterial STIs, Dept Bacteriol, Bordeaux, France.
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- Bebear, Cecile (författare)
- CHU Bordeaux, French Natl Reference Ctr Bacterial STIs, Dept Bacteriol, Bordeaux, France.
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- Lewis, David A. (författare)
- Univ Sydney, Marie Bashir Inst Infect Dis & Biosecur, Sydney, NSW, Australia.;Univ Sydney, Westmead Clin Sch, Sydney, NSW, Australia.;Western Sydney Local Hlth Dist, Western Sydney Sexual Hlth Ctr, Parramatta, NSW, Australia.
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- Puerta, Teresa (författare)
- Hosp Clin San Carlos, Ctr Sanitario Sandoval, Unidad ITS VIH, Inst Invest Sanitaria San Carlos IdISSC, Madrid, Spain.
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- Kese, Darja (författare)
- Univ Ljubljana, Inst Microbiol & Immunol, Fac Med, Ljubljana, Slovenia.
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- Balla, Eszter (författare)
- Natl Ctr Epidemiol, Bacterial STI Reference Lab, Budapest, Hungary.
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- Zakoucka, Hana (författare)
- Natl Inst Publ Hlth, Natl Reference Lab Diagnost Syphilis & Chlamydia, Srobarova 48, Prague 10, Czech Republic.
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- Rob, Filip (författare)
- Charles Univ & Hosp Bulovka, Fac Med 2, Dept Dermatovenereol, Budinova 2, Prague 18081 8, Czech Republic.
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- Morre, Servaas A. (författare)
- VU Univ Med Ctr Amsterdam, Dept Med Microbiol & Infect Control, Lab Immunogenet, Amsterdam, Netherlands.;Univ Maastricht, Inst Publ Hlth Genom IPHG, Res Inst GROW, Dept Genet & Cell Biol, Maastricht, Netherlands.
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de Barbeyrac, Bertille (författare)
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- Galan, Juan Carlos (författare)
- Hosp Univ Ramon & Cajal, Inst Ramon & Cajal Invest Sanitaria IRYCIS, Serv Microbiol, Madrid, Spain.;CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Venezuela.
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- Vries, Henry J. C. (författare)
- GGD Publ Hlth Serv Amsterdam, Dept Infect Dis, Amsterdam, Netherlands.;Univ Amsterdam, Acad Med Ctr, Amsterdam UMC, Amsterdam Inst Infect & Immun AII, Amsterdam, Netherlands.
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- Thomson, Nicholas R. (författare)
- Wellcome Trust Sanger Inst, Cambridge, England.;London Sch Hyg & Trop Med, Clin Res Dept, London, England.
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- Goldenberger, Daniel (författare)
- Univ Basel, Univ Hosp Basel, Clin Bacteriol & Mycol, Basel, Switzerland.
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- Egli, Adrian (författare)
- Univ Basel, Univ Hosp Basel, Clin Bacteriol & Mycol, Basel, Switzerland.;Univ Basel, Dept Biomed, Appl Microbiol Res, Basel, Switzerland.
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Univ Basel, Univ Hosp Basel, Clin Bacteriol & Mycol, Basel, Switzerland;Univ Basel, Dept Biomed, Appl Microbiol Res, Basel, Switzerland.;SIB Swiss Inst Bioinformat, Basel, Switzerland. Wellcome Trust Sanger Inst, Cambridge, England.;Univ Autonoma Barcelona, VHIR, Healthcare Syst Res Grp, Passeig Vall dHebron 119-129, Barcelona 08035, Spain. (creator_code:org_t)
- Microbiology Society, 2021
- 2021
- Engelska.
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Ingår i: Microbial Genomics. - : Microbiology Society. - 2057-5858. ; 7:6
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Lymphogranuloma venereum (LGV), the invasive infection of the sexually transmissible infection (STI) Chlamydia trachomatis, is caused by strains from the LGV biovar, most commonly represented by ompA- genotypes L2b and L2. We investigated the diversity in LGV samples across an international collection over seven years using typing and genome sequencing. LGV- positive samples (n=321) from eight countries collected between 2011 and 2017 (Spain n=97, Netherlands n=67, Switzerland n=64, Australia n=53, Sweden n=37, Hungary n=31, Czechia n=30, Slovenia n=10) were genotyped for pmpH and ompA variants. All were found to contain the 9 bp insertion in the pmpH gene, previously associated with ompA- genotype L2b. However, analysis of the ompA gene shows ompA- genotype L2b (n=83), ompA- genotype L2 (n=180) and several variants of these (n=52; 12 variant types), as well as other/mixed ompA-genotypes (n=6). To elucidate the genomic diversity, whole genome sequencing (WGS) was performed from selected samples using SureSelect target enrichment, resulting in 42 genomes, covering a diversity of ompA- genotypes and representing most of the countries sampled. A phylogeny of these data clearly shows that these ompA- genotypes derive from an ompA- genotype L2b ancestor, carrying up to eight SNPs per isolate. SNPs within ompA are overrep-resented among genomic changes in these samples, each of which results in an amino acid change in the variable domains of OmpA (major outer membrane protein, MOMP). A reversion to ompA- genotype L2 with the L2b genomic backbone is commonly seen. The wide diversity of ompA- genotypes found in these recent LGV samples indicates that this gene is under immunological selection. Our results suggest that the ompA- genotype L2b genomic backbone is the dominant strain circulating and evolving particularly in men who have sex with men (MSM) populations.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Nyckelord
- whole genome sequencing
- selective pressure
- outer membrane protein
- sexually transmitted infections
- homosexuality
- surveillance
- molecular epidemiology
- evolution
- LGV
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Seth-Smith, Hele ...
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Benard, Angele
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Bruisten, Sylvia ...
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Versteeg, Bart
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Herrmann, Björn, ...
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Kok, Jen
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visa fler...
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Carter, Ian
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Peuchant, Olivia
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Bebear, Cecile
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Lewis, David A.
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Puerta, Teresa
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Kese, Darja
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Balla, Eszter
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Zakoucka, Hana
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Rob, Filip
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Morre, Servaas A ...
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de Barbeyrac, Be ...
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Galan, Juan Carl ...
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Vries, Henry J. ...
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Thomson, Nichola ...
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Goldenberger, Da ...
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Egli, Adrian
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