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The relationship of NT-proBNP and dialysis parameters with outcome of incident haemodialysis patients: results from the membrane permeability outcome study
- Article/chapterEnglish2013
Publisher, publication year, extent ...
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2013-03-28
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S. Karger AG,2013
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:127335673
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http://kipublications.ki.se/Default.aspx?queryparsed=id:127335673URI
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https://doi.org/10.1159/000347076DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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<b><i>Background/Aims:</i></b> The association of raised levels of natriuretic peptides with elevated risk of mortality was investigated in the present analysis of the Membrane Permeability Outcome study. <b><i>Methods:</i></b> N-terminal probrain type natriuretic peptide (NT-proBNP) was measured in 618 incident haemodialysis patients, randomised to either high-flux or low-flux. Characteristics of patients with NT-proBNP levels below or above the median were descriptively analysed and survival analysis was performed. <b><i>Results:</i></b> Median NT-proBNP value was 2,124 pg/ml, with 1,854 pg/ml in the high-flux and 2,919 pg/ml in the low-flux group. Survival probability was lowest in patients with both a history of cardiovascular disease and NT-proBNP values above the median (p < 0.001). A multivariate Cox proportional hazard model showed interaction between presence of cardiovascular diseases and NT-proBNP levels above the median. <b><i>Conclusions:</i></b> NT-proBNP is an independent predictor of mortality also in incident haemodialysis patients. Lower concentrations associated with high-flux dialysis suggest a possible biological link to improved survival in this group.
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Hannedouche, T
(author)
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Martin-Malo, A
(author)
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Jacobson, SHKarolinska Institutet
(author)
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Vanholder, R
(author)
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Ronco, C
(author)
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La Milia, V
(author)
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Gomez, JML
(author)
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Stefoni, S
(author)
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Maheut, H
(author)
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Klinger, M
(author)
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Krummel, T
(author)
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Dhondt, A
(author)
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Berdud, I
(author)
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Gauly, A
(author)
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Karolinska Institutet
(creator_code:org_t)
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In:Blood purification: S. Karger AG35:1-3, s. 216-2231421-97350253-5068
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Locatelli, F
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Hannedouche, T
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Martin-Malo, A
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Jacobson, SH
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Vanholder, R
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Ronco, C
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La Milia, V
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Gomez, JML
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Stefoni, S
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Maheut, H
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Klinger, M
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Krummel, T
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Dhondt, A
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Berdud, I
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Gauly, A
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- MEDICAL AND HEALTH SCIENCES
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Karolinska Institutet