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  • Locatelli, F (author)

The relationship of NT-proBNP and dialysis parameters with outcome of incident haemodialysis patients: results from the membrane permeability outcome study

  • Article/chapterEnglish2013

Publisher, publication year, extent ...

  • 2013-03-28
  • S. Karger AG,2013

Numbers

  • LIBRIS-ID:oai:prod.swepub.kib.ki.se:127335673
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:127335673URI
  • https://doi.org/10.1159/000347076DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • <b><i>Background/Aims:</i></b> The association of raised levels of natriuretic peptides with elevated risk of mortality was investigated in the present analysis of the Membrane Permeability Outcome study. <b><i>Methods:</i></b> N-terminal probrain type natriuretic peptide (NT-proBNP) was measured in 618 incident haemodialysis patients, randomised to either high-flux or low-flux. Characteristics of patients with NT-proBNP levels below or above the median were descriptively analysed and survival analysis was performed. <b><i>Results:</i></b> Median NT-proBNP value was 2,124 pg/ml, with 1,854 pg/ml in the high-flux and 2,919 pg/ml in the low-flux group. Survival probability was lowest in patients with both a history of cardiovascular disease and NT-proBNP values above the median (p < 0.001). A multivariate Cox proportional hazard model showed interaction between presence of cardiovascular diseases and NT-proBNP levels above the median. <b><i>Conclusions:</i></b> NT-proBNP is an independent predictor of mortality also in incident haemodialysis patients. Lower concentrations associated with high-flux dialysis suggest a possible biological link to improved survival in this group.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Hannedouche, T (author)
  • Martin-Malo, A (author)
  • Jacobson, SHKarolinska Institutet (author)
  • Vanholder, R (author)
  • Ronco, C (author)
  • La Milia, V (author)
  • Gomez, JML (author)
  • Stefoni, S (author)
  • Maheut, H (author)
  • Klinger, M (author)
  • Krummel, T (author)
  • Dhondt, A (author)
  • Berdud, I (author)
  • Gauly, A (author)
  • Karolinska Institutet (creator_code:org_t)

Related titles

  • In:Blood purification: S. Karger AG35:1-3, s. 216-2231421-97350253-5068

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