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Male germ cell deve...
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Stukenborg, JBKarolinska Institutet
(författare)
Male germ cell development in humans
- Artikel/kapitelEngelska2014
Förlag, utgivningsår, omfång ...
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2013-12-19
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S. Karger AG,2014
Nummerbeteckningar
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:128514046
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http://kipublications.ki.se/Default.aspx?queryparsed=id:128514046URI
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https://doi.org/10.1159/000355599DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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<b><i>Background:</i></b> Germ cells are unique cells that possess the ability to transmit genetic information between generations. Detailed knowledge about the molecular and cellular mechanisms determining the fate of human male germ cells still remains sparse. This is partially due to ethical issues limiting the access to research material. Therefore, the mechanisms of proliferation, differentiation and apoptosis of human male germ cells still remain challenging study objectives. <b><i>Methods:</i></b> This review focuses on using English articles accessible in PubMed as well as personal files on the current knowledge of the molecular and cellular mechanisms connected with human testicular germ cell development, maturation failure and the possibility of fertility preservation in patients in whom there is a risk of gonadal failure. However, since rodents, particularly mice, offer the possibility of studying germ cell development by use of genetic modification techniques, some studies using animal models are also discussed. <b><i>Conclusion:</i></b> This mini review focuses on the current knowledge about male germ cells. However, the reader is referred to two previous mini reviews focusing on testicular somatic cells, i.e. on Sertoli cells and Leydig cells.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Kjartansdottir, KRKarolinska Institutet
(författare)
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Reda, AKarolinska Institutet
(författare)
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Colon, E
(författare)
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Albersmeier, JP
(författare)
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Soder, OKarolinska Institutet
(författare)
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Karolinska Institutet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Hormone research in paediatrics: S. Karger AG81:1, s. 2-121663-28261663-2818
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