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Ventilation managem...
Ventilation management and outcomes in out-of-hospital cardiac arrest: a protocol for a preplanned secondary analysis of the TTM2 trial
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- Robba, C. (author)
- University of Genoa,Ospedale Policlinico San Martino,IRCCS Oncol & Neurosci, Italy; Univ Genoa, Italy
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- Nielsen, Niklas (author)
- Lund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Kliniska Vetenskaper, Helsingborg,Institutionen för kliniska vetenskaper, Lund,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Sciences, Helsingborg,Department of Clinical Sciences, Lund,Lund Univ, Sweden
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- Dankiewicz, Josef (author)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Sweden
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- Badenes, R. (author)
- University and Polytechnic Hospital la Fe,Univ Valencia, Spain
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- Battaglini, D. (author)
- University of Genoa,University of Barcelona,Ospedale Policlinico San Martino,IRCCS Oncol & Neurosci, Italy; Univ Genoa, Italy; Univ Barcelona, Italy
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- Ball, L. (author)
- Ospedale Policlinico San Martino,University of Genoa,IRCCS Oncol & Neurosci, Italy; Univ Genoa, Italy
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- Brunetti, I. (author)
- Ospedale Policlinico San Martino,IRCCS Oncol & Neurosci, Italy
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- David, W. G. P. (author)
- University Hospital of Zurich,University of Genoa,Ospedale Policlinico San Martino,Univ Hosp Zurich, Switzerland,IRCCS Oncol & Neurosci, Italy; Univ Genoa, Italy
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- Young, P. (author)
- Wellington Hospital, New Zealand,Wellington Hosp, New Zealand
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- Eastwood, G. (author)
- Deakin University,Deakin Univ, Australia
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- Chew, Michelle S. (author)
- Linköpings universitet,Linköping University,Avdelningen för klinisk kemi och farmakologi,Medicinska fakulteten,Region Östergötland, ANOPIVA US
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- Jakobsen, J. (author)
- Karolinska Institutet
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- Unden, Johan (author)
- Lund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Halmstad County Hospital,Lund Univ, Sweden; Hallands Hosp Halmstad, Sweden
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- Thomas, M. (author)
- University Hospitals Bristol NHS Foundation Trust,Univ Hosp Bristol NHS Fdn Trust, England
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- Joannidis, M. (author)
- Medical University of Innsbruck,Med Univ Innsbruck, Austria
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- Nichol, A. (author)
- Monash University,Monash Univ, Australia
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- Lundin, Andreas (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för anestesiologi och intensivvård,Institute of Clinical Sciences, Department of Anesthesiology and Intensive care,Univ Gothenburg, Sweden
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- Hollenberg, J. (author)
- Karolinska Institute,Karolinska Inst, Sweden
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- Lilja, Gisela (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Sweden
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- Hammond, N. E. (author)
- The George Institute for Global Health,George Inst Global Hlth, Australia
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- Saxena, M. (author)
- St George Hospital, Sidney,St George Hosp, Australia
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- Martin, A. (author)
- Skåne University Hospital,Lund Univ, Sweden
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- Solar, M. (author)
- Charles University in Prague,Charles Univ Prague, Czech Republic
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- Taccone, F. S. (author)
- Université Libre de Bruxelles (ULB),Univ Libre Bruxelles, Belgium
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- Friberg, Hans A. (author)
- Lund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Sweden
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Pelosi, P. (author)
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(creator_code:org_t)
- 2022-03-03
- 2022
- English.
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In: BMJ Open. - : BMJ. - 2044-6055. ; 12:3
- Related links:
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Abstract
Subject headings
Close
- Introduction Mechanical ventilation is a fundamental component in the management of patients post cardiac arrest. However, the ventilator settings and the gas-exchange targets used after cardiac arrest may not be optimal to minimise post-anoxic secondary brain injury. Therefore, questions remain regarding the best ventilator management in such patients. Methods and analysis This is a preplanned analysis of the international randomised controlled trial, targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest (OHCA)-target temperature management 2 (TTM2). The primary objective is to describe ventilatory settings and gas exchange in patients who required invasive mechanical ventilation and included in the TTM2 trial. Secondary objectives include evaluating the association of ventilator settings and gas-exchange values with 6 months mortality and neurological outcome. Adult patients after an OHCA who were included in the TTM2 trial and who received invasive mechanical ventilation will be eligible for this analysis. Data collected in the TTM2 trial that will be analysed include patients' prehospital characteristics, clinical examination, ventilator settings and arterial blood gases recorded at hospital and intensive care unit (ICU) admission and daily during ICU stay. Ethics and dissemination The TTM2 study has been approved by the regional ethics committee at Lund University and by all relevant ethics boards in participating countries. No further ethical committee approval is required for this secondary analysis. Data will be disseminated to the scientific community by abstracts and by original articles submitted to peer-reviewed journals.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- respiratory-distress-syndrome
- therapeutic hypothermia
- carbon-dioxide
- association
- metaanalysis
- survival
- hyperoxia
- care
- resuscitation
- guidelines
- General & Internal Medicine
- adult intensive & critical care
- clinical trials
- respiratory physiology
Publication and Content Type
- ref (subject category)
- art (subject category)
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BMJ Open
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To the university's database
- By the author/editor
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Robba, C.
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Nielsen, Niklas
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Dankiewicz, Jose ...
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Badenes, R.
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Battaglini, D.
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Ball, L.
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show more...
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Brunetti, I.
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David, W. G. P.
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Young, P.
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Eastwood, G.
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Chew, Michelle S ...
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Jakobsen, J.
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Unden, Johan
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Thomas, M.
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Joannidis, M.
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Nichol, A.
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Lundin, Andreas
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Hollenberg, J.
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Lilja, Gisela
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Hammond, N. E.
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Saxena, M.
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Martin, A.
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Solar, M.
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Taccone, F. S.
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Friberg, Hans A.
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Pelosi, P.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Anesthesiology a ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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BMJ Open
- By the university
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University of Gothenburg
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Lund University
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Linköping University
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Karolinska Institutet