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Autoantibody respon...
Autoantibody response against NALP5/MATER in primary ovarian insufficiency and in autoimmune Addison's disease
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- Brozzetti, A (author)
- Univ Perugia, Dept Internal Med, I-06126 Perugia, Italy.
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- Alimohammadi, Mohammad (author)
- Uppsala universitet,Dermatologi och venereologi,Science for Life Laboratory, SciLifeLab
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- Morelli, S (author)
- Univ Perugia, Dept Internal Med, I-06126 Perugia, Italy.
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- Minarelli, V (author)
- Univ Perugia, Dept Internal Med, I-06126 Perugia, Italy.
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- Hallgren, A (author)
- Karolinska Inst, Dept Med Solna, Ctr Mol Med, S-17176 Stockholm, Sweden.
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- Giordano, R (author)
- Univ Turin, Dept Med Sci, Div Endocrinol Diabetol & Metab, I-10126 Turin, Italy.
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- De Bellis, A (author)
- Univ Naples 2, Endocrinol Unit, Dept Cardiothorac & Resp Sci, I-80132 Naples, Italy.
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- Perniola, R (author)
- V Fazzi Reg Hosp, Dept Pediat Neonatal Intens Care, I-73100 Lecce, Italy.
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- Kämpe, Olle (author)
- Uppsala universitet,Karolinska Institutet,Autoimmunitet,Science for Life Laboratory, SciLifeLab
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- Falorni, A (author)
- Univ Perugia, Dept Internal Med, I-06126 Perugia, Italy
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Univ Perugia, Dept Internal Med, I-06126 Perugia, Italy Dermatologi och venereologi (creator_code:org_t)
- The Endocrine Society, 2015
- 2015
- English.
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In: The Journal of clinical endocrinology and metabolism. - : The Endocrine Society. - 1945-7197 .- 0021-972X. ; 100:5, s. 1941-1948
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Abstract
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- Context:NACHT leucine-rich-repeat protein 5 (NALP5)/maternal antigen that embryo requires (MATER) is an autoantigen in hypoparathyroidism associated with autoimmune polyendocrine syndrome type 1 (APS1) but is also expressed in the ovary. Mater is an autoantigen in experimental autoimmune oophoritis.Objectives:The objectives of the study were to determine the frequency of NALP5/MATER autoantibodies (NALP5/MATER-Ab) in women with premature ovarian insufficiency (POI) and in patients with autoimmune Addison's disease (AAD) and to evaluate whether inhibin chains are a target for autoantibodies in POI.Methods:Autoantibodies against NALP5/MATER and inhibin chains-α and -βA were determined by radiobinding assays in 172 patients with AAD without clinical signs of gonadal insufficiency, 41 women with both AAD and autoimmune POI [steroidogenic cell autoimmune POI (SCA-POI)], 119 women with idiopathic POI, 19 patients with APS1, and 211 healthy control subjects.Results:NALP5/MATER-Ab were detected in 11 of 19 (58%) sera from APS1 patients, 12 of 172 (7%) AAD sera, 5 of 41 (12%) SCA-POI sera, 0 of 119 idiopathic POI sera and 1 of 211 healthy control sera (P < .001). None of 160 POI sera, including 41 sera from women with SCA-POI and 119 women with idiopathic POI, and none of 211 healthy control sera were positive for inhibin chain-α/βA autoantibodies.Conclusions:NALP5/MATER-Ab are associated with hypoparathyroidism in APS1 but are present also in patients with AAD and in women with SCA-POI without hypoparathyroidism. Inhibin chains do not appear to be likely candidate targets of autoantibodies in human POI.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Brozzetti, A
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Alimohammadi, Mo ...
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Morelli, S
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Minarelli, V
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Hallgren, A
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Giordano, R
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show more...
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De Bellis, A
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Perniola, R
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Kämpe, Olle
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Falorni, A
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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The Journal of c ...
- By the university
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Karolinska Institutet
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Uppsala University