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  • Giampietro, CFIRC Inst Mol Oncol, I-20139 Milan, Italy.;Univ Milan, Dept Biosci, I-20133 Milan, Italy. (author)

The alternative splicing factor Nova2 regulates vascular development and lumen formation

  • Article/chapterEnglish2015

Publisher, publication year, extent ...

  • 2015-10-08
  • Springer Science and Business Media LLC,2015

Numbers

  • LIBRIS-ID:oai:prod.swepub.kib.ki.se:132437667
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:132437667URI
  • https://doi.org/10.1038/ncomms9479DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-269995URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Vascular lumen formation is a fundamental step during angiogenesis; yet, the molecular mechanisms underlying this process are poorly understood. Recent studies have shown that neural and vascular systems share common anatomical, functional and molecular similarities. Here we show that the organization of endothelial lumen is controlled at the post-transcriptional level by the alternative splicing (AS) regulator Nova2, which was previously considered to be neural cell-specific. Nova2 is expressed during angiogenesis and its depletion disrupts vascular lumen formation in vivo. Similarly, Nova2 depletion in cultured endothelial cells (ECs) impairs the apical distribution and the downstream signalling of the Par polarity complex, resulting in altered EC polarity, a process required for vascular lumen formation. These defects are linked to AS changes of Nova2 target exons affecting the Par complex and its regulators. Collectively, our results reveal that Nova2 functions as an AS regulator in angiogenesis and is a novel member of the ‘angioneurins’ family.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Deflorian, GFIRC Inst Mol Oncol, I-20139 Milan, Italy. (author)
  • Gallo, SCNR, Ist Genet Mol, I-27100 Pavia, Italy.;IUSS Ist Univ Super, I-27100 Pavia, Italy. (author)
  • Di Matteo, ACNR, Ist Genet Mol, I-27100 Pavia, Italy.;Lazzaro Spallanzani Univ Pavia, Dipartimento Biol & Biotecnol, I-27100 Pavia, Italy. (author)
  • Pradella, DCNR, Ist Genet Mol, I-27100 Pavia, Italy.;Lazzaro Spallanzani Univ Pavia, Dipartimento Biol & Biotecnol, I-27100 Pavia, Italy. (author)
  • Bonomi, SCNR, Ist Genet Mol, I-27100 Pavia, Italy. (author)
  • Belloni, ECNR, Ist Genet Mol, I-27100 Pavia, Italy. (author)
  • Nyqvist, DKarolinska Institutet,Karolinska Inst, Dept Med Biochem & Biophys, Div Vasc Biol, S-17177 Stockholm, Sweden. (author)
  • Quaranta, VCNR, Ist Genet Mol, I-27100 Pavia, Italy. (author)
  • Confalonieri, SFIRC Inst Mol Oncol, I-20139 Milan, Italy.;Ist Europeo Oncol, Dipartimento Oncol Sperimentale, I-20141 Milan, Italy. (author)
  • Bertalot, GIst Europeo Oncol, Dipartimento Oncol Sperimentale, I-20141 Milan, Italy. (author)
  • Orsenigo, FFIRC Inst Mol Oncol, I-20139 Milan, Italy. (author)
  • Pisati, FFIRC Inst Mol Oncol, I-20139 Milan, Italy. (author)
  • Ferrero, EIst Sci San Raffaele, Dept Oncol, I-20132 Milan, Italy. (author)
  • Biamonti, GCNR, Ist Genet Mol, I-27100 Pavia, Italy. (author)
  • Fredrickx, EIst Sci San Raffaele, Div Neurosci, I-20132 Milan, Italy.;Ist Sci San Raffaele, INSPE, I-20132 Milan, Italy. (author)
  • Taveggia, CIst Sci San Raffaele, Div Neurosci, I-20132 Milan, Italy.;Ist Sci San Raffaele, INSPE, I-20132 Milan, Italy. (author)
  • Wyatt, CDRCtr Genom Regulat CRG, EMBL CRG Res Unit Syst Biol, Barcelona 08003, Spain.;Univ Pompeu Fabra UPF, Barcelona 08003, Spain. (author)
  • Irimia, MCtr Genom Regulat CRG, EMBL CRG Res Unit Syst Biol, Barcelona 08003, Spain.;Univ Pompeu Fabra UPF, Barcelona 08003, Spain. (author)
  • Di Fiore, PPFIRC Inst Mol Oncol, I-20139 Milan, Italy.;Ist Europeo Oncol, Dipartimento Oncol Sperimentale, I-20141 Milan, Italy.;Univ Milan, Dipartimento Sci Salute, I-20122 Milan, Italy. (author)
  • Blencowe, BJUniv Toronto, Donnelly Ctr Cellular & Biomol Res, Toronto, ON M5S 3E1, Canada. (author)
  • Dejana, ElisabettaUppsala universitet,Vaskulärbiologi,FIRC Inst Mol Oncol, I-20139 Milan, Italy.;Univ Milan, Dept Biosci, I-20133 Milan, Italy.(Swepub:uu)elide443 (author)
  • Ghigna, CCNR, Ist Genet Mol, I-27100 Pavia, Italy. (author)
  • FIRC Inst Mol Oncol, I-20139 Milan, Italy.;Univ Milan, Dept Biosci, I-20133 Milan, Italy.FIRC Inst Mol Oncol, I-20139 Milan, Italy. (creator_code:org_t)

Related titles

  • In:Nature communications: Springer Science and Business Media LLC6, s. 8479-2041-1723

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