Search: ((WFRF:(Conti DV)) pers:(Park JY)) >
Atlas of prostate c...
Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation
- Article/chapterEnglish2016
Publisher, publication year, extent ...
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2016-04-07
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Springer Science and Business Media LLC,2016
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:133315652
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http://kipublications.ki.se/Default.aspx?queryparsed=id:133315652URI
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https://doi.org/10.1038/ncomms10979DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-122103URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Although genome-wide association studies have identified over 100 risk loci that explain ∼33% of familial risk for prostate cancer (PrCa), their functional effects on risk remain largely unknown. Here we use genotype data from 59,089 men of European and African American ancestries combined with cell-type-specific epigenetic data to build a genomic atlas of single-nucleotide polymorphism (SNP) heritability in PrCa. We find significant differences in heritability between variants in prostate-relevant epigenetic marks defined in normal versus tumour tissue as well as between tissue and cell lines. The majority of SNP heritability lies in regions marked by H3k27 acetylation in prostate adenoc7arcinoma cell line (LNCaP) or by DNaseI hypersensitive sites in cancer cell lines. We find a high degree of similarity between European and African American ancestries suggesting a similar genetic architecture from common variation underlying PrCa risk. Our findings showcase the power of integrating functional annotation with genetic data to understand the genetic basis of PrCa.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Shi, H
(author)
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Kichaev, G
(author)
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Pomerantz, M
(author)
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Li, F
(author)
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Long, HW
(author)
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Ingles, SA
(author)
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Kittles, RA
(author)
-
Strom, SS
(author)
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Rybicki, BA
(author)
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Nemesure, B
(author)
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Isaacs, WB
(author)
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Zheng, W
(author)
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Pettaway, CA
(author)
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Yeboah, ED
(author)
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Tettey, Y
(author)
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Biritwum, RB
(author)
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Adjei, AA
(author)
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Tay, E
(author)
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Truelove, A
(author)
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Niwa, S
(author)
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Chokkalingam, AP
(author)
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John, EM
(author)
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Murphy, ABKarolinska Institutet
(author)
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Signorello, LB
(author)
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Carpten, J
(author)
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Leske, MC
(author)
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Wu, SY
(author)
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Johansson, MattiasUmeå universitet,Enheten för biobanksforskning,Urologi och andrologi(Swepub:umu)masmas97
(author)
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Neslund-Dudas, C
(author)
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Hsing, AW
(author)
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Chu, L
(author)
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Goodman, PJ
(author)
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Klein, EA
(author)
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Witte, JS
(author)
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Casey, G
(author)
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Kaggwa, S
(author)
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Cook, MB
(author)
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Stram, DO
(author)
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Blot, WJ
(author)
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Eeles, RA
(author)
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Easton, D
(author)
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Kote-Jarai, Z
(author)
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Al Olama, AA
(author)
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Benlloch, S
(author)
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Muir, K
(author)
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Giles, GG
(author)
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Southey, MC
(author)
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Fitzgerald, LM
(author)
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Gronberg, HKarolinska Institutet
(author)
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Wiklund, FKarolinska Institutet
(author)
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Aly, MKarolinska Institutet
(author)
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Henderson, BE
(author)
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Schleutker, J
(author)
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Wahlfors, T
(author)
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Tammela, TLJ
(author)
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Nordestgaard, BG
(author)
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Key, TJ
(author)
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Travis, RC
(author)
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Neal, DE
(author)
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Donovan, JL
(author)
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Hamdy, FC
(author)
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Pharoah, P
(author)
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Pashayan, N
(author)
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Khaw, KT
(author)
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Stanford, JL
(author)
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Thibodeau, SN
(author)
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McDonnell, SK
(author)
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Schaid, DJ
(author)
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Maier, C
(author)
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Vogel, W
(author)
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Luedeke, M
(author)
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Herkommer, K
(author)
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Kibel, AS
(author)
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Cybulski, C
(author)
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Wokolorczyk, D
(author)
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Kluzniak, W
(author)
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Cannon-Albright, L
(author)
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Teerlink, C
(author)
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Brenner, H
(author)
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Dieffenbach, AK
(author)
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Arndt, V
(author)
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Park, JY
(author)
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Sellers, TA
(author)
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Lin, HY
(author)
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Slavov, C
(author)
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Kaneva, R
(author)
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Mitev, V
(author)
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Batra, J
(author)
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Spurdle, A
(author)
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Clements, JAKarolinska Institutet
(author)
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Teixeira, MR
(author)
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Pandha, H
(author)
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Michael, A
(author)
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Paulo, P
(author)
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Maia, S
(author)
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Kierzek, A
(author)
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Conti, DV
(author)
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Albanes, D
(author)
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Berg, C
(author)
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Berndt, SI
(author)
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Campa, D
(author)
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Crawford, ED
(author)
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Diver, WR
(author)
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Gapstur, SM
(author)
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Gaziano, JM
(author)
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Giovannucci, E
(author)
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Hoover, R
(author)
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Hunter, DJ
(author)
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Johansson, M
(author)
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Kraft, P
(author)
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Le Marchand, L
(author)
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Lindstrom, S
(author)
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Navarro, C
(author)
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Overvad, K
(author)
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Riboli, E
(author)
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Siddiq, A
(author)
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Stevens, VL
(author)
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Trichopoulos, D
(author)
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Vineis, P
(author)
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Yeager, M
(author)
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Trynka, G
(author)
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Raychaudhuri, S
(author)
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Schumacher, FR
(author)
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Price, AL
(author)
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Freedman, ML
(author)
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Haiman, CA
(author)
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Pasaniuc, B
(author)
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Cook, M
(author)
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Guy, M
(author)
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Govindasami, K
(author)
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Leongamornlert, D
(author)
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Sawyer, EJ
(author)
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Wilkinson, R
(author)
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Saunders, EJ
(author)
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Tymrakiewicz, M
(author)
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Dadaev, T
(author)
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Morgan, A
(author)
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Fisher, C
(author)
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Hazel, S
(author)
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Livni, N
(author)
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Lophatananon, A
(author)
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Pedersen, J
(author)
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Hopper, JL
(author)
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Adolfson, JKarolinska Institutet
(author)
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Stattin, P
(author)
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Johansson, JE
(author)
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Cavalli-Bjoerkman, C
(author)
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Karlsson, A
(author)
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Broms, M
(author)
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Auvinen, A
(author)
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Kujala, P
(author)
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Maeaettaenen, L
(author)
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Murtola, T
(author)
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Taari, K
(author)
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Weischer, M
(author)
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Nielsen, SF
(author)
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Klarskov, P
(author)
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Roder, A
(author)
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Iversen, P
(author)
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Wallinder, H
(author)
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Gustafsson, S
(author)
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Cox, A
(author)
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Brown, P
(author)
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George, A
(author)
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Marsden, G
(author)
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Lane, A
(author)
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Davis, M
(author)
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Zheng, W
(author)
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Signorello, LB
(author)
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Blot, WJ
(author)
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Tillmans, L
(author)
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Riska, S
(author)
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Wang, L
(author)
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Rinckleb, A
(author)
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Lubiski, J
(author)
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Stegmaier, C
(author)
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Pow-Sang, J
(author)
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Park, H
(author)
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Radlein, S
(author)
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Rincon, M
(author)
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Haley, J
(author)
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Zachariah, B
(author)
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Kachakova, D
(author)
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Popov, E
(author)
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Mitkova, A
(author)
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Vlahova, A
(author)
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Dikov, T
(author)
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Christova, S
(author)
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Heathcote, P
(author)
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Wood, G
(author)
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Malone, G
(author)
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Saunders, P
(author)
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Eckert, A
(author)
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Yeadon, T
(author)
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Kerr, K
(author)
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Collins, A
(author)
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Turner, M
(author)
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Srinivasan, S
(author)
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Kedda, MA
(author)
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Alexander, K
(author)
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Omara, T
(author)
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Wu, HH
(author)
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Henrique, R
(author)
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Pinto, P
(author)
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Santos, J
(author)
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Barros-Silva, J
(author)
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Karolinska InstitutetEnheten för biobanksforskning
(creator_code:org_t)
Related titles
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In:Nature communications: Springer Science and Business Media LLC7, s. 10979-2041-1723
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- By the author/editor
-
Gusev, A
-
Shi, H
-
Kichaev, G
-
Pomerantz, M
-
Li, F
-
Long, HW
-
show more...
-
Ingles, SA
-
Kittles, RA
-
Strom, SS
-
Rybicki, BA
-
Nemesure, B
-
Isaacs, WB
-
Zheng, W
-
Pettaway, CA
-
Yeboah, ED
-
Tettey, Y
-
Biritwum, RB
-
Adjei, AA
-
Tay, E
-
Truelove, A
-
Niwa, S
-
Chokkalingam, AP
-
John, EM
-
Murphy, AB
-
Signorello, LB
-
Carpten, J
-
Leske, MC
-
Wu, SY
-
Johansson, Matti ...
-
Neslund-Dudas, C
-
Hsing, AW
-
Chu, L
-
Goodman, PJ
-
Klein, EA
-
Witte, JS
-
Casey, G
-
Kaggwa, S
-
Cook, MB
-
Stram, DO
-
Blot, WJ
-
Eeles, RA
-
Easton, D
-
Kote-Jarai, Z
-
Al Olama, AA
-
Benlloch, S
-
Muir, K
-
Giles, GG
-
Southey, MC
-
Fitzgerald, LM
-
Gronberg, H
-
Wiklund, F
-
Aly, M
-
Henderson, BE
-
Schleutker, J
-
Wahlfors, T
-
Tammela, TLJ
-
Nordestgaard, BG
-
Key, TJ
-
Travis, RC
-
Neal, DE
-
Donovan, JL
-
Hamdy, FC
-
Pharoah, P
-
Pashayan, N
-
Khaw, KT
-
Stanford, JL
-
Thibodeau, SN
-
McDonnell, SK
-
Schaid, DJ
-
Maier, C
-
Vogel, W
-
Luedeke, M
-
Herkommer, K
-
Kibel, AS
-
Cybulski, C
-
Wokolorczyk, D
-
Kluzniak, W
-
Cannon-Albright, ...
-
Teerlink, C
-
Brenner, H
-
Dieffenbach, AK
-
Arndt, V
-
Park, JY
-
Sellers, TA
-
Lin, HY
-
Slavov, C
-
Kaneva, R
-
Mitev, V
-
Batra, J
-
Spurdle, A
-
Clements, JA
-
Teixeira, MR
-
Pandha, H
-
Michael, A
-
Paulo, P
-
Maia, S
-
Kierzek, A
-
Conti, DV
-
Albanes, D
-
Berg, C
-
Berndt, SI
-
Campa, D
-
Crawford, ED
-
Diver, WR
-
Gapstur, SM
-
Gaziano, JM
-
Giovannucci, E
-
Hoover, R
-
Hunter, DJ
-
Johansson, M
-
Kraft, P
-
Le Marchand, L
-
Lindstrom, S
-
Navarro, C
-
Overvad, K
-
Riboli, E
-
Siddiq, A
-
Stevens, VL
-
Trichopoulos, D
-
Vineis, P
-
Yeager, M
-
Trynka, G
-
Raychaudhuri, S
-
Schumacher, FR
-
Price, AL
-
Freedman, ML
-
Haiman, CA
-
Pasaniuc, B
-
Cook, M
-
Guy, M
-
Govindasami, K
-
Leongamornlert, ...
-
Sawyer, EJ
-
Wilkinson, R
-
Saunders, EJ
-
Tymrakiewicz, M
-
Dadaev, T
-
Morgan, A
-
Fisher, C
-
Hazel, S
-
Livni, N
-
Lophatananon, A
-
Pedersen, J
-
Hopper, JL
-
Adolfson, J
-
Stattin, P
-
Johansson, JE
-
Cavalli-Bjoerkma ...
-
Karlsson, A
-
Broms, M
-
Auvinen, A
-
Kujala, P
-
Maeaettaenen, L
-
Murtola, T
-
Taari, K
-
Weischer, M
-
Nielsen, SF
-
Klarskov, P
-
Roder, A
-
Iversen, P
-
Wallinder, H
-
Gustafsson, S
-
Cox, A
-
Brown, P
-
George, A
-
Marsden, G
-
Lane, A
-
Davis, M
-
Tillmans, L
-
Riska, S
-
Wang, L
-
Rinckleb, A
-
Lubiski, J
-
Stegmaier, C
-
Pow-Sang, J
-
Park, H
-
Radlein, S
-
Rincon, M
-
Haley, J
-
Zachariah, B
-
Kachakova, D
-
Popov, E
-
Mitkova, A
-
Vlahova, A
-
Dikov, T
-
Christova, S
-
Heathcote, P
-
Wood, G
-
Malone, G
-
Saunders, P
-
Eckert, A
-
Yeadon, T
-
Kerr, K
-
Collins, A
-
Turner, M
-
Srinivasan, S
-
Kedda, MA
-
Alexander, K
-
Omara, T
-
Wu, HH
-
Henrique, R
-
Pinto, P
-
Santos, J
-
Barros-Silva, J
-
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- MEDICAL AND HEALTH SCIENCES
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