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Personality Polygen...
Personality Polygenes, Positive Affect, and Life Satisfaction
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- Weiss, A (författare)
- University of Edinburgh
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- Baselmans, BML (författare)
- Institute for Research in Extramural Medicine (NL),VU University (NL),University of Edinburgh,University of Minnesota Twin Cities (US)
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- Hofer, E (författare)
- Medical University of Graz
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- Yang, JY (författare)
- Rush University Medical Center
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- Okbay, A (författare)
- Erasmus School of Economics (NL)
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- Lind, PA (författare)
- University of Edinburgh,QIMR Berghofer Medical Research Institute
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Miller, MB (författare)
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- Nolte, IM (författare)
- University of Groningen (NL)
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- Zhao, W (författare)
- University of Michigan (US)
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- Hagenaars, SP (författare)
- University of Edinburgh,University of Groningen (NL)
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- Hottenga, JJ (författare)
- VU University (NL)
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- Matteson, LK (författare)
- University of Minnesota Twin Cities (US)
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Snieder, H (författare)
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- Faul, JD (författare)
- University of Michigan (US)
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- Hartman, CA (författare)
- University of Groningen (NL)
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- Boyle, PA (författare)
- Rush University Medical Center
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- Tiemeier, H (författare)
- Erasmus University (NL)
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- Mosing, MA (författare)
- Karolinska Institutet,Karolinska Institutet (SE)
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Pattie, A (författare)
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- Davies, G (författare)
- University of Edinburgh
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- Liewald, DC (författare)
- University of Edinburgh,Center for Experimental Social Science
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- Schmidt, R (författare)
- Medical University of Graz
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- De Jager, PL (författare)
- Harvard University (US)
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- Heath, AC (författare)
- Washington University (US)
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- Jokela, M (författare)
- University of Helsinki (FI)
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- Johannesson, Magnus (författare)
- Stockholm School of Economics,Handelshögskolan i Stockholm
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- Oldehinkel, AJ (författare)
- University of Groningen (NL)
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Johannesson, M (författare)
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Cesarini, D (författare)
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- Hofman, A (författare)
- Erasmus University (NL)
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- Harris, SE (författare)
- University of Edinburgh
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- Smith, JA (författare)
- University of Michigan (US)
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- Keltikangas-Jarvinen, L (författare)
- University of Helsinki (FI)
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- Pulkki-Raback, L (författare)
- University of Helsinki (FI)
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- Schmidt, H (författare)
- Medical University of Graz
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Smith, J (författare)
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- Iacono, WG (författare)
- University of Minnesota Twin Cities (US)
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McGue, M (författare)
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- Bennett, DA (författare)
- Rush University Medical Center
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- Pedersen, NL (författare)
- Karolinska Institutet,Karolinska Institutet (SE)
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- Magnusson, PKE (författare)
- Karolinska Institutet,Vrije Universiteit Amsterdam
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- Deary, IJ (författare)
- University of Edinburgh
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- Martin, NG (författare)
- Queensland Institute of Medical Research
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- Boomsma, DI (författare)
- VU University (NL)
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Bartels, M (författare)
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Luciano, M (författare)
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(creator_code:org_t)
- 2016-08-22
- 2016
- Engelska.
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Ingår i: Twin research and human genetics : the official journal of the International Society for Twin Studies. - : Cambridge University Press (CUP). - 1832-4274 .- 1839-2628. ; 19:5, s. 407-417
- Relaterad länk:
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https://www.cambridg...
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http://kipublication...
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https://doi.org/10.1...
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https://research.hhs...
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Abstract
Ämnesord
Stäng
- Approximately half of the variation in wellbeing measures overlaps with variation in personality traits. Studies of non-human primate pedigrees and human twins suggest that this is due to common genetic influences. We tested whether personality polygenic scores for the NEO Five-Factor Inventory (NEO-FFI) domains and for item response theory (IRT) derived extraversion and neuroticism scores predict variance in wellbeing measures. Polygenic scores were based on published genome-wide association (GWA) results in over 17,000 individuals for the NEO-FFI and in over 63,000 for the IRT extraversion and neuroticism traits. The NEO-FFI polygenic scores were used to predict life satisfaction in 7 cohorts, positive affect in 12 cohorts, and general wellbeing in 1 cohort (maximalN= 46,508). Meta-analysis of these results showed no significant association between NEO-FFI personality polygenic scores and the wellbeing measures. IRT extraversion and neuroticism polygenic scores were used to predict life satisfaction and positive affect in almost 37,000 individuals from UK Biobank. Significant positive associations (effect sizes <0.05%) were observed between the extraversion polygenic score and wellbeing measures, and a negative association was observed between the polygenic neuroticism score and life satisfaction. Furthermore, using GWA data, genetic correlations of -0.49 and -0.55 were estimated between neuroticism with life satisfaction and positive affect, respectively. The moderate genetic correlation between neuroticism and wellbeing is in line with twin research showing that genetic influences on wellbeing are also shared with other independent personality domains.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Weiss, A
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Baselmans, BML
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Hofer, E
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Yang, JY
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Okbay, A
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Lind, PA
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visa fler...
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Miller, MB
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Nolte, IM
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Zhao, W
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Hagenaars, SP
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Hottenga, JJ
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Matteson, LK
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Snieder, H
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Faul, JD
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Hartman, CA
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Boyle, PA
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Tiemeier, H
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Mosing, MA
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Pattie, A
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Davies, G
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Liewald, DC
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Schmidt, R
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De Jager, PL
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Heath, AC
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Jokela, M
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Johannesson, Mag ...
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Oldehinkel, AJ
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Johannesson, M
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Cesarini, D
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Hofman, A
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Harris, SE
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Smith, JA
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Keltikangas-Jarv ...
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Pulkki-Raback, L
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Schmidt, H
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Smith, J
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Iacono, WG
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McGue, M
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Bennett, DA
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Pedersen, NL
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Magnusson, PKE
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Deary, IJ
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Martin, NG
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Boomsma, DI
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Bartels, M
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Luciano, M
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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Twin research an ...
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Twin Research an ...
- Av lärosätet
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Karolinska Institutet
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Handelshögskolan i Stockholm