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- Loley, CUniv Lubeck, Univ Klinikum Schleswig Holstein, Inst Med Biometrie & Stat, Campus Lubeck, Lubeck, Germany.;DZHK German Ctr Cardiovasc Res, Partner Site Hamburg Lubeck Kiel, Lubeck, Germany. (author)
No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis
- Article/chapterEnglish2016
Publisher, publication year, extent ...
- 2016-10-12
- Springer Science and Business Media LLC,2016
Numbers
- LIBRIS-ID:oai:prod.swepub.kib.ki.se:134434679
- http://kipublications.ki.se/Default.aspx?queryparsed=id:134434679URI
- https://doi.org/10.1038/srep35278DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-307543URI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- In recent years, genome-wide association studies have identified 58 independent risk loci for coronary artery disease (CAD) on the autosome. However, due to the sex-specific data structure of the X chromosome, it has been excluded from most of these analyses. While females have 2 copies of chromosome X, males have only one. Also, one of the female X chromosomes may be inactivated. Therefore, special test statistics and quality control procedures are required. Thus, little is known about the role of X-chromosomal variants in CAD. To fill this gap, we conducted a comprehensive X-chromosome-wide meta-analysis including more than 43,000 CAD cases and 58,000 controls from 35 international study cohorts. For quality control, sex-specific filters were used to adequately take the special structure of X-chromosomal data into account. For single study analyses, several logistic regression models were calculated allowing for inactivation of one female X-chromosome, adjusting for sex and investigating interactions between sex and genetic variants. Then, meta-analyses including all 35 studies were conducted using random effects models. None of the investigated models revealed genome-wide significant associations for any variant. Although we analyzed the largest-to-date sample, currently available methods were not able to detect any associations of X-chromosomal variants with CAD.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
- Alver, MUniv Tartu, Estonian Genome Ctr, Tartu, Estonia.;Inst Mol & Cell Biol, Tartu, Estonia. (author)
- Lind, LarsUppsala universitet,Kardiovaskulär epidemiologi(Swepub:uu)larslind (author)
- Bjonnes, AMassachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA. (author)
- Goel, AUniv Oxford, Div Cardiovasc Med, Radcliffe Dept Med, Oxford, England.;Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England. (author)
- Gustafsson, StefanUppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)stegu732 (author)
- Hernesniemi, JFimlab Labs, Dept Clin Chem, Tampere, Finland.;Heart Hosp, Dept Cariol, Tampere, Finland.;Univ Tampere, Sch Med, Tampere, Finland. (author)
- Hopewell, JCUniv Oxford, Nuffield Dept Populat Hlth, CTSU, Oxford, England. (author)
- Kanoni, SQueen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.,Univ Oklahoma, Hlth Sci Ctr, Coll Med, Dept Pediat, Oklahoma City, OK 73190 USA.;Univ Oklahoma, Hlth Sci Ctr, Coll Pharm, Dept Pharmaceut Sci, Oklahoma City, OK 73190 USA.;Oklahoma Ctr Neurosci, Oklahoma City, OK USA. (author)
- Kleber, MEHeidelberg Univ, Med Fac Mannheim, Dept Med 5, Mannheim, Germany.,Heart Hosp, Dept Cariol, Tampere, Finland.;Univ Tampere, Sch Med, Tampere, Finland.,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.,Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.,Univ Tartu, Estonian Genome Ctr, Tartu, Estonia. (author)
- Lau, KWUniv Oxford, Nuffield Dept Populat Hlth, CTSU, Oxford, England. (author)
- Lu, YCIcahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA. (author)
- Lyytikainen, LPFimlab Labs, Dept Clin Chem, Tampere, Finland.;Univ Tampere, Sch Med, Dept Clin Chem, Tampere, Finland. (author)
- Nelson, CPUniv Leicester, Dept Cardiovasc Sci, Leicester, Leics, England.;Glenfield Hosp, NIHR Leicester Cardiovasc Biomed Res Unit, Leicester, Leics, England. (author)
- Nikpay, MUniv Ottawa, Inst Heart, Ruddy Canadian Cardiovasc Genet Ctr, Ottawa, ON, Canada. (author)
- Qu, LMUniv Penn, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA. (author)
- Salfati, EStanford Univ, Sch Med Stanford, Dept Med, Div Cardiovasc Med, Stanford, CA USA. (author)
- Scholz, MUniv Leipzig, Fac Med, Inst Med Informat Stat & Epidemiol, Leipzig, Germany.;LIFE Res Ctr Civilizat Dis, Leipzig, Germany. (author)
- Tukiainen, T (author)
- Willenborg, CDZHK German Ctr Cardiovasc Res, Partner Site Hamburg Lubeck Kiel, Lubeck, Germany.;Univ Lubeck, Univ Klinikum Schleswig Holstein, Inst Integrat & Expt Genom, Campus Lubeck, Lubeck, Germany.;Univ Heart Ctr Luebeck, Campus Lubeck, Lubeck, Germany. (author)
- Won, HHSungkyunkwan Univ, Samsung Med Ctr, SAIHST, Seoul, South Korea. (author)
- Zeng, LYTech Univ Munich, Deutsch Herzzentrum Munchen, Munich, Germany.;DZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, Munich, Germany. (author)
- Zhang, WHImperial Coll London, Dept Epidemiol & Biostat, London, England.;Ealing Hosp Natl Hlth Serv NHS Trust, Dept Cardiol, Southall, Middx, England.,Univ Oxford, Div Cardiovasc Med, Radcliffe Dept Med, Oxford, England.;Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England. (author)
- Anand, SSMcMaster Univ, Populat Hlth Res Inst, Hamilton, ON, Canada. (author)
- Beutner, FLIFE Res Ctr Civilizat Dis, Leipzig, Germany.;Univ Leipzig, Heart Ctr Leipzig, Cardiol, Leipzig, Germany. (author)
- Bottinger, EPIcahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA. (author)
- Clarke, RUniv Oxford, Nuffield Dept Populat Hlth, CTSU, Oxford, England. (author)
- Dedoussis, GHarokopio Univ Athens, Athens, Greece. (author)
- Do, RIcahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Ctr Stat Genet, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Icahn Inst Genom & Multiscale Biol, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Zena & Michael A Weiner Cardiovasc Inst, New York, NY 10029 USA. (author)
- Esko, TUniv Tartu, Estonian Genome Ctr, Tartu, Estonia.;Harvard Med Sch, Dept Med, Boston, MA USA. (author)
- Eskola, M (author)
- Farrall, MUniv Oxford, Div Cardiovasc Med, Radcliffe Dept Med, Oxford, England.;Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England. (author)
- Gauguier, DINSERM, Ctr Rech Cordeliers, UMRS1138, Paris, France. (author)
- Giedraitis, VilmantasUppsala universitet,Geriatrik(Swepub:uu)vigie517 (author)
- Granger, CBDuke Univ, Sch Med, Durham, NC USA. (author)
- Hall, ASUniv Leeds, Leeds Inst Genet Hlth & Therapeut, Leeds LS2 9JT, W Yorkshire, England. (author)
- Hamsten, AKarolinska Institutet,Karolinska Inst, Dept Med Solna, Atherosclerosis Res Unit, Cardiovasc Genet & Genom Grp, Stockholm, Sweden. (author)
- Hazen, SLCleveland Clin, Cleveland, OH 44106 USA. (author)
- Huang, JBoston VA Res Inst Inc, Boston, MA USA. (author)
- Kahonen, MTampere Univ Hosp, Dept Clin Physiol, Tampere, Finland.;Univ Tampere, Sch Med, Dept Clin Physiol, Tampere, Finland. (author)
- Kyriakou, TUniv Oxford, Div Cardiovasc Med, Radcliffe Dept Med, Oxford, England.;Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England. (author)
- Laaksonen, RFimlab Labs, Dept Clin Chem, Tampere, Finland.;Univ Tampere, Sch Med, Dept Clin Chem, Tampere, Finland.;Zora Biosci, Espoo, Finland. (author)
- Lind, L (author)
- Lindgren, CUniv Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;MIT, Broad Inst, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;Harvard Univ, Cambridge, MA 02138 USA. (author)
- Magnusson, PKEKarolinska Institutet (author)
- Marouli, E (author)
- Mihailov, E (author)
- Morris, APUniv Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Liverpool, Dept Biostat, Liverpool, Merseyside, England. (author)
- Nikus, KHeart Hosp, Dept Cariol, Tampere, Finland.;Univ Tampere, Sch Med, Tampere, Finland. (author)
- Pedersen, NKarolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden. (author)
- Rallidis, LUniv Gen Hosp Attikon, Dept Cardiol 2, Athens, Greece. (author)
- Salomaa, VNatl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland. (author)
- Shah, SHDuke Univ, Sch Med, Durham, NC USA.,DZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, Munich, Germany.;Imperial Coll London, Dept Epidemiol & Biostat, London, England. (author)
- Stewart, AFRUniv Ottawa, Inst Heart, Ruddy Canadian Cardiovasc Genet Ctr, Ottawa, ON, Canada. (author)
- Thompson, JRUniv Leicester, Dept Hlth Sci, Leicester, Leics, England. (author)
- Zalloua, PALebanese Amer Univ, Sch Med, Beirut, Lebanon.;Harvard Sch Publ Hlth, Boston, MA USA. (author)
- Chambers, JCEaling Hosp Natl Hlth Serv NHS Trust, Dept Cardiol, Southall, Middx, England.;McMaster Univ, Populat Hlth Res Inst, Hamilton, ON, Canada.;Imperial Coll Healthcare NHS Trust, London, England. (author)
- Collins, RUniv Oxford, Nuffield Dept Populat Hlth, CTSU, Oxford, England. (author)
- Ingelsson, ErikUppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.(Swepub:uu)ering425 (author)
- Iribarren, CKaiser Permanente, Div Res, Oakland, CA USA. (author)
- Karhunen, PJFimlab Labs, Dept Clin Chem, Tampere, Finland.;Univ Tampere, Sch Med, Dept Forens Med, Tampere, Finland. (author)
- Kooner, JSMcMaster Univ, Populat Hlth Res Inst, Hamilton, ON, Canada.;Imperial Coll Healthcare NHS Trust, London, England.;Imperial Coll London, Cardiovasc Sci, Natl Heart & Lung Inst, London, England. (author)
- Lehtimaki, TFimlab Labs, Dept Clin Chem, Tampere, Finland.;Univ Tampere, Sch Med, Dept Clin Chem, Tampere, Finland. (author)
- Loos, RJFIcahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Mindich Child Hlth & Dev Inst, New York, NY 10029 USA. (author)
- Marz, WHeidelberg Univ, Med Fac Mannheim, Dept Med 5, Mannheim, Germany.;Synlab Serv GmbH, Synlab Acad, Mannheim, Germany.;Med Univ Graz, Clin Inst Med & Chem Lab Diagnost, Graz, Austria. (author)
- McPherson, RUniv Ottawa, Inst Heart, Ruddy Canadian Cardiovasc Genet Ctr, Ottawa, ON, Canada. (author)
- Metspalu, AUniv Tartu, Estonian Genome Ctr, Tartu, Estonia.;Inst Mol & Cell Biol, Tartu, Estonia. (author)
- Reilly, MPUniv Penn, Cardiovasc Inst, Perelman Sch Med, Philadelphia, PA 19104 USA. (author)
- Ripatti, SKaiser Permanente, Div Res, Oakland, CA USA.;Univ Helsinki, Hjelt Inst, Helsinki, Finland.;Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki, Finland. (author)
- Sanghera, DK (author)
- Thiery, JLIFE Res Ctr Civilizat Dis, Leipzig, Germany.;Univ Hosp Leipzig, Fac Med, Inst Lab Med Clin Chem & Mol Diagnost, Leipzig, Germany. (author)
- Watkins, H (author)
- Deloukas, PQueen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.;Wellcome Trust Sanger Inst, Cambridge, England.;King Abdulaziz Univ, Princess Al Jawhara Al Brahim Ctr Excellence Res, Jeddah, Saudi Arabia. (author)
- Kathiresan, SMassachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA.;Broad Inst, Program Med & Populat Genet, Cambridge, MA USA.;Harvard Med Sch, Dept Med, Boston, MA USA.;Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA. (author)
- Samani, NJUniv Leicester, Dept Cardiovasc Sci, Leicester, Leics, England.;Glenfield Hosp, NIHR Leicester Cardiovasc Biomed Res Unit, Leicester, Leics, England. (author)
- Schunkert, H (author)
- Erdmann, JDZHK German Ctr Cardiovasc Res, Partner Site Hamburg Lubeck Kiel, Lubeck, Germany.;Univ Lubeck, Univ Klinikum Schleswig Holstein, Inst Integrat & Expt Genom, Campus Lubeck, Lubeck, Germany.;Univ Heart Ctr Luebeck, Campus Lubeck, Lubeck, Germany. (author)
- Konig, IRUniv Lubeck, Univ Klinikum Schleswig Holstein, Inst Med Biometrie & Stat, Campus Lubeck, Lubeck, Germany.;DZHK German Ctr Cardiovasc Res, Partner Site Hamburg Lubeck Kiel, Lubeck, Germany. (author)
- Univ Lubeck, Univ Klinikum Schleswig Holstein, Inst Med Biometrie & Stat, Campus Lubeck, Lubeck, Germany.;DZHK German Ctr Cardiovasc Res, Partner Site Hamburg Lubeck Kiel, Lubeck, Germany.Univ Tartu, Estonian Genome Ctr, Tartu, Estonia.;Inst Mol & Cell Biol, Tartu, Estonia. (creator_code:org_t)
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- Lind, Lars
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- Hernesniemi, J
- Hopewell, JC
- Kanoni, S
- Kleber, ME
- Lau, KW
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- Lyytikainen, LP
- Nelson, CP
- Nikpay, M
- Qu, LM
- Salfati, E
- Scholz, M
- Tukiainen, T
- Willenborg, C
- Won, HH
- Zeng, LY
- Zhang, WH
- Anand, SS
- Beutner, F
- Bottinger, EP
- Clarke, R
- Dedoussis, G
- Do, R
- Esko, T
- Eskola, M
- Farrall, M
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- Hall, AS
- Hamsten, A
- Hazen, SL
- Huang, J
- Kahonen, M
- Kyriakou, T
- Laaksonen, R
- Lind, L
- Lindgren, C
- Magnusson, PKE
- Marouli, E
- Mihailov, E
- Morris, AP
- Nikus, K
- Pedersen, N
- Rallidis, L
- Salomaa, V
- Shah, SH
- Stewart, AFR
- Thompson, JR
- Zalloua, PA
- Chambers, JC
- Collins, R
- Ingelsson, Erik
- Iribarren, C
- Karhunen, PJ
- Kooner, JS
- Lehtimaki, T
- Loos, RJF
- Marz, W
- McPherson, R
- Metspalu, A
- Reilly, MP
- Ripatti, S
- Sanghera, DK
- Thiery, J
- Watkins, H
- Deloukas, P
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- Samani, NJ
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