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  • Aggarwal, R (author)

2016 American College of Rheumatology/European League Against Rheumatism criteria for minimal, moderate, and major clinical response in adult dermatomyositis and polymyositis: An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • 2017-04-06
  • BMJ,2017

Numbers

  • LIBRIS-ID:oai:prod.swepub.kib.ki.se:135467646
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:135467646URI
  • https://doi.org/10.1136/annrheumdis-2017-211400DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • To develop response criteria for adult dermatomyositis (DM) and polymyositis (PM). Expert surveys, logistic regression, and conjoint analysis were used to develop 287 definitions using core set measures. Myositis experts rated greater improvement among multiple pairwise scenarios in conjoint analysis surveys, where different levels of improvement in 2 core set measures were presented. The PAPRIKA (Potentially All Pairwise Rankings of All Possible Alternatives) method determined the relative weights of core set measures and conjoint analysis definitions. The performance characteristics of the definitions were evaluated on patient profiles using expert consensus (gold standard) and were validated using data from a clinical trial. The nominal group technique was used to reach consensus. Consensus was reached for a conjoint analysis-based continuous model using absolute per cent change in core set measures (physician, patient, and extramuscular global activity, muscle strength, Health Assessment Questionnaire, and muscle enzyme levels). A total improvement score (range 0–100), determined by summing scores for each core set measure, was based on improvement in and relative weight of each core set measure. Thresholds for minimal, moderate, and major improvement were ≥20, ≥40, and ≥60 points in the total improvement score. The same criteria were chosen for juvenile DM, with different improvement thresholds. Sensitivity and specificity in DM/PM patient cohorts were 85% and 92%, 90% and 96%, and 92% and 98% for minimal, moderate, and major improvement, respectively. Definitions were validated in the clinical trial analysis for differentiating the physician rating of improvement (p<0.001). The response criteria for adult DM/PM consisted of the conjoint analysis model based on absolute per cent change in 6 core set measures, with thresholds for minimal, moderate, and major improvement.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Rider, LG (author)
  • Ruperto, N (author)
  • Bayat, N (author)
  • Erman, B (author)
  • Feldman, BM (author)
  • Oddis, CV (author)
  • Amato, AA (author)
  • Chinoy, H (author)
  • Cooper, RG (author)
  • Dastmalchi, M (author)
  • Fiorentino, D (author)
  • Isenberg, D (author)
  • Katz, JD (author)
  • Mammen, A (author)
  • de Visser, M (author)
  • Ytterberg, SR (author)
  • Lundberg, IEKarolinska Institutet (author)
  • Chung, L (author)
  • Danko, K (author)
  • Garcia-De la Torre, I (author)
  • Song, YW (author)
  • Villa, L (author)
  • Rinaldi, M (author)
  • Rockette, H (author)
  • Lachenbruch, PA (author)
  • Miller, FW (author)
  • Vencovsky, J (author)
  • Karolinska Institutet (creator_code:org_t)

Related titles

  • In:Annals of the rheumatic diseases: BMJ76:5, s. 792-8011468-20600003-4967

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