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  • Altmae, S (author)

Meta-signature of human endometrial receptivity: a meta-analysis and validation study of transcriptomic biomarkers

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • 2017-08-30
  • Springer Science and Business Media LLC,2017

Numbers

  • LIBRIS-ID:oai:prod.swepub.kib.ki.se:136551013
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:136551013URI
  • https://doi.org/10.1038/s41598-017-10098-3DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Previous transcriptome studies of the human endometrium have revealed hundreds of simultaneously up- and down-regulated genes that are involved in endometrial receptivity. However, the overlap between the studies is relatively small, and we are still searching for potential diagnostic biomarkers. Here we perform a meta-analysis of endometrial-receptivity associated genes on 164 endometrial samples (76 from ‘pre-receptive’ and 88 from mid-secretory, ‘receptive’ phase endometria) using a robust rank aggregation (RRA) method, followed by enrichment analysis, and regulatory microRNA prediction. We identify a meta-signature of endometrial receptivity involving 57 mRNA genes as putative receptivity markers, where 39 of these we confirm experimentally using RNA-sequencing method in two separate datasets. The meta-signature genes highlight the importance of immune responses, the complement cascade pathway and the involvement of exosomes in mid-secretory endometrial functions. Bioinformatic prediction identifies 348 microRNAs that could regulate 30 endometrial-receptivity associated genes, and we confirm experimentally the decreased expression of 19 microRNAs with 11 corresponding up-regulated meta-signature genes in our validation experiments. The 57 identified meta-signature genes and involved pathways, together with their regulatory microRNAs could serve as promising and sought-after biomarkers of endometrial receptivity, fertility and infertility.

Added entries (persons, corporate bodies, meetings, titles ...)

  • Koel, M (author)
  • Vosa, U (author)
  • Adler, P (author)
  • Suhorutsenko, M (author)
  • Laisk-Podar, T (author)
  • Kukushkina, V (author)
  • Saare, M (author)
  • Velthut-Meikas, A (author)
  • Krjutskov, K (author)
  • Aghajanova, L (author)
  • Lalitkumar, PGKarolinska Institutet (author)
  • Gemzell-Danielsson, KKarolinska Institutet (author)
  • Giudice, L (author)
  • Simon, C (author)
  • Salumets, A (author)
  • Karolinska Institutet (creator_code:org_t)

Related titles

  • In:Scientific reports: Springer Science and Business Media LLC7:1, s. 10077-2045-2322

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