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Effects of Amerindi...
Effects of Amerindian Genetic Ancestry on Clinical Variables and Therapy in Patients with Rheumatoid Arthritis
- Article/chapterEnglish2017
Publisher, publication year, extent ...
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2017-11-01
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The Journal of Rheumatology,2017
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:137176504
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http://kipublications.ki.se/Default.aspx?queryparsed=id:137176504URI
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https://doi.org/10.3899/jrheum.160485DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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To define whether Amerindian genetic ancestry correlates with clinical and therapeutic variables in admixed individuals with rheumatoid arthritis (RA) from Latin America.Methods.Patients with RA (n = 1347) and healthy controls (n = 1012) from Argentina, Mexico, Chile, and Peru were included. Samples were genotyped for the Immunochip v1 using the Illumina platform. Clinical data were obtained through interviews or the clinical history.Results.Percentage of Amerindian ancestry was comparable between cases and controls. Morning stiffness (p < 0.0001, OR 0.05), rheumatoid factor (RF; p < 0.0001, OR 0.22), radiographic changes (p < 0.0001, OR 0.05), and higher number of criteria were associated with lower Amerindian ancestry after Bonferroni correction. Higher Amerindian ancestry correlated only with weight loss (pBonferroni < 0.0001, OR 2.85). Increased Amerindian ancestry correlated with higher doses of azathioprine (p < 0.0001, OR 163.6) and sulfasalazine (p < 0.0001, OR 48.6), and inversely with methotrexate (p = 0.001, OR 0.35), leflunomide (p = 0.001, OR 0.16), and nonsteroidal antiinflammatory drugs (pBonferroni = 0.001, OR 0.37). Only the presence of RF and weight loss were modified after confounders adjustment.Conclusion.Amerindian ancestry protects against most major clinical criteria of RA, but regarding the association of RF with increased European ancestry, age, sex, and smoking are modifiers. Ancestry also correlates with the therapeutic profiles.
Added entries (persons, corporate bodies, meetings, titles ...)
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de la Torre, IG
(author)
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Sacnun, M
(author)
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Goni, M
(author)
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Berbotto, G
(author)
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Paira, S
(author)
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Musuruana, JL
(author)
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Graf, C
(author)
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Alvarellos, A
(author)
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Messina, OD
(author)
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Babini, A
(author)
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Strusberg, I
(author)
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Marcos, JC
(author)
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Scherbarth, H
(author)
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Spindler, A
(author)
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Quinteros, A
(author)
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Toloza, S
(author)
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Moreno, JLC
(author)
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Catoggio, LJ
(author)
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Tate, G
(author)
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Eimon, A
(author)
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Citera, G
(author)
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Pellet, AC
(author)
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Nasswetter, G
(author)
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Cardiel, MH
(author)
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Miranda, P
(author)
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Ballesteros, F
(author)
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Esquivel-Valerio, JA
(author)
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Maradiaga-Cecena, MA
(author)
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Acevedo-Vasquez, EM
(author)
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Garcia, CG
(author)
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Tusie-Luna, T
(author)
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Pons-Estel, BA
(author)
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Alarcon-Riquelme, MEKarolinska Institutet
(author)
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Karolinska Institutet
(creator_code:org_t)
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In:The Journal of rheumatology: The Journal of Rheumatology44:12, s. 1804-18120315-162X1499-2752
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Sanchez, E
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de la Torre, IG
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Sacnun, M
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Goni, M
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Berbotto, G
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Paira, S
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Musuruana, JL
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Graf, C
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Alvarellos, A
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Messina, OD
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Babini, A
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Strusberg, I
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Marcos, JC
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Scherbarth, H
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Spindler, A
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Quinteros, A
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Toloza, S
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Moreno, JLC
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Catoggio, LJ
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Tate, G
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Eimon, A
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Citera, G
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Pellet, AC
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Nasswetter, G
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Cardiel, MH
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Miranda, P
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Ballesteros, F
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Esquivel-Valerio ...
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Maradiaga-Cecena ...
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Acevedo-Vasquez, ...
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Garcia, CG
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Tusie-Luna, T
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Pons-Estel, BA
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Karolinska Institutet