Search: id:"swepub:oai:prod.swepub.kib.ki.se:137244055" >
The EuroMyositis re...
The EuroMyositis registry: an international collaborative tool to facilitate myositis research
- Article/chapterEnglish2018
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:prod.swepub.kib.ki.se:137244055
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:137244055URI
-
https://doi.org/10.1136/annrheumdis-2017-211868DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
The EuroMyositis Registry facilitates collaboration across the idiopathic inflammatory myopathy (IIM) research community. This inaugural report examines pooled Registry data.MethodsCross-sectional analysis of IIM cases from 11 countries was performed. Associations between clinical subtypes, extramuscular involvement, environmental exposures and medications were investigated.ResultsOf 3067 IIM cases, 69% were female. The most common IIM subtype was dermatomyositis (DM) (31%). Smoking was more frequent in connective tissue disease overlap cases (45%, OR 1.44, 95% CI 1.09 to 1.90, p=0.012). Smoking was associated with interstitial lung disease (ILD) (OR 1.32, 95% CI 1.06 to 1.65, p=0.013), dysphagia (OR 1.43, 95% CI 1.16 to 1.77, p=0.001), malignancy ever (OR 1.78, 95% CI 1.36 to 2.33, p<0.001) and cardiac involvement (OR 2.40, 95% CI 1.60 to 3.60, p<0.001).Dysphagia occurred in 39% and cardiac involvement in 9%; either occurrence was associated with higher Health Assessment Questionnaire (HAQ) scores (adjusted OR 1.79, 95% CI 1.43 to 2.23, p<0.001). HAQ scores were also higher in inclusion body myositis cases (adjusted OR 3.85, 95% CI 2.52 to 5.90, p<0.001). Malignancy (ever) occurred in 13%, most commonly in DM (20%, OR 2.06, 95% CI 1.65 to 2.57, p<0.001).ILD occurred in 30%, most frequently in antisynthetase syndrome (71%, OR 10.7, 95% CI 8.6 to 13.4, p<0.001). Rash characteristics differed between adult-onset and juvenile-onset DM cases (‘V’ sign: 56% DM vs 16% juvenile-DM, OR 0.16, 95% CI 0.07 to 0.36, p<0.001). Glucocorticoids were used in 98% of cases, methotrexate in 71% and azathioprine in 51%.ConclusionThis large multicentre cohort demonstrates the importance of extramuscular involvement in patients with IIM, its association with smoking and its influence on disease severity. Our findings emphasise that IIM is a multisystem inflammatory disease and will help inform prognosis and clinical management of patients.
Added entries (persons, corporate bodies, meetings, titles ...)
-
Vencovsky, J
(author)
-
Wang, GC
(author)
-
Wedderburn, LR
(author)
-
Diederichsen, LP
(author)
-
Schmidt, J
(author)
-
Oakley, P
(author)
-
Benveniste, O
(author)
-
Danieli, MG
(author)
-
Danko, K
(author)
-
Thuy, NTP
(author)
-
Vazquez-Del Mercado, M
(author)
-
Andersson, H
(author)
-
De Paepe, B
(author)
-
debleecker, JL
(author)
-
Maurer, B
(author)
-
McCann, LJ
(author)
-
Pipitone, N
(author)
-
McHugh, N
(author)
-
Betteridge, ZE
(author)
-
New, P
(author)
-
Cooper, RG
(author)
-
Ollier, WE
(author)
-
Lamb, JA
(author)
-
Krogh, NS
(author)
-
Lundberg, IEKarolinska Institutet
(author)
-
Chinoy, H
(author)
-
Karolinska Institutet
(creator_code:org_t)
Related titles
-
In:Annals of the rheumatic diseases: BMJ77:1, s. 30-391468-20600003-4967
Internet link
Find in a library
To the university's database
- By the author/editor
-
Lilleker, JB
-
Vencovsky, J
-
Wang, GC
-
Wedderburn, LR
-
Diederichsen, LP
-
Schmidt, J
-
show more...
-
Oakley, P
-
Benveniste, O
-
Danieli, MG
-
Danko, K
-
Thuy, NTP
-
Vazquez-Del Merc ...
-
Andersson, H
-
De Paepe, B
-
debleecker, JL
-
Maurer, B
-
McCann, LJ
-
Pipitone, N
-
McHugh, N
-
Betteridge, ZE
-
New, P
-
Cooper, RG
-
Ollier, WE
-
Lamb, JA
-
Krogh, NS
-
Lundberg, IE
-
Chinoy, H
-
show less...
- Articles in the publication
-
Annals of the rh ...
- By the university
-
Karolinska Institutet