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Reading and editing...
Reading and editing the Pleurodeles waltl genome reveals novel features of tetrapod regeneration
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- Elewa, A (författare)
- Karolinska Institutet,Karolinska Institute, Department of Cell and Molecular Biology
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- Wang, H (författare)
- Huazhong Agricultural University, College of Animal Science and Technology
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- Talavera-Lopez, C (författare)
- Karolinska Institute, Department of Cell and Molecular Biology; Francis Crick Institute
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- Joven, A (författare)
- Karolinska Institutet,Karolinska Institute, Department of Cell and Molecular Biology
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- Brito, G (författare)
- Karolinska Institute, Department of Cell and Molecular Biology
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- Kumar, A (författare)
- Karolinska Institutet,Karolinska Institute, Department of Cell and Molecular Biology
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- Hameed, LS (författare)
- Karolinska Institutet,Karolinska Institute, Department of Cell and Molecular Biology
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- Penrad-Mobayed, M (författare)
- CNRS, Institut Jacques Monod; University Paris-Diderot
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- Yao, ZY (författare)
- Karolinska Institute, Department of Cell and Molecular Biology
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- Zamani, Neda (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Uppsala Univ, Dept Med Biochem & Microbiol, SE-75123 Uppsala, Sweden.
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- Abbas, Y (författare)
- Harvard University, Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute
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- Abdullayev, I (författare)
- Karolinska Institute, Department of Cell and Molecular Biology; Ludwig Institute for Cancer Research
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- Sandberg, R (författare)
- Karolinska Institutet,Karolinska Institute, Department of Cell and Molecular Biology; Ludwig Institute for Cancer Research
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- Grabherr, Manfred (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Andersson, B (författare)
- Karolinska Institutet,Karolinska Institute, Department of Cell and Molecular Biology
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- Simon, A (författare)
- Karolinska Institutet,Karolinska Institute, Department of Cell and Molecular Biology
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(creator_code:org_t)
- 2017-12-22
- 2017
- Engelska.
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8:1, s. 2286-
- Relaterad länk:
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https://www.nature.c...
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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http://kipublication...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Salamanders exhibit an extraordinary ability among vertebrates to regenerate complex body parts. However, scarce genomic resources have limited our understanding of regeneration in adult salamanders. Here, we present the ~20 Gb genome and transcriptome of the Iberian ribbed newt Pleurodeles waltl, a tractable species suitable for laboratory research. We find that embryonic stem cell-specific miRNAs mir-93b and mir-427/430/302, as well as Harbinger DNA transposons carrying the Myb-like proto-oncogene have expanded dramatically in the Pleurodeleswaltl genome and are co-expressed during limb regeneration. Moreover, we find that a family of salamander methyltransferases is expressed specifically in adult appendages. Using CRISPR/Cas9 technology to perturb transcription factors, we demonstrate that, unlike the axolotl, Pax3 is present and necessary for development and that contrary to mammals, muscle regeneration is normal without functional Pax7 gene. Our data provide a foundation for comparative genomic studies that generate models for the uneven distribution of regenerative capacities among vertebrates.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
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Elewa, A
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Wang, H
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Talavera-Lopez, ...
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Joven, A
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Brito, G
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Kumar, A
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visa fler...
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Hameed, LS
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Penrad-Mobayed, ...
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Yao, ZY
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Zamani, Neda
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Abbas, Y
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Abdullayev, I
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Sandberg, R
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Grabherr, Manfre ...
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Andersson, B
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Simon, A
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Karolinska Institutet
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Uppsala universitet