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Sökning: WFRF:(Lundberg AM) > (2015-2019) > Augmented Th17 diff...

  • Brauner, SKarolinska Institutet (författare)

Augmented Th17 differentiation in Trim21 deficiency promotes a stable phenotype of atherosclerotic plaques with high collagen content

  • Artikel/kapitelEngelska2018

Förlag, utgivningsår, omfång ...

  • 2017-09-04
  • Oxford University Press (OUP),2018

Nummerbeteckningar

  • LIBRIS-ID:oai:prod.swepub.kib.ki.se:137391424
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:137391424URI
  • https://doi.org/10.1093/cvr/cvx181DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • AimsPatients with hyperlipidemia are at risk of atherosclerosis, but not all develop cardiovascular disease, highlighting the importance of other risk factors such as inflammation. Both the innate and adaptive arms of the immune system have been suggested in the initiation and propagation of plaque formation. Tri-partite motif (TRIM) 21 is a regulator of tissue inflammation and pro-inflammatory cytokine production, and has been implicated in chronic inflammatory disease. Here, we investigate a potential role for TRIM21 in coronary artery disease.Methods and resultsTrim21-deficient or wild-type bone marrow was transplanted into Ldlr-/- mice fed a hypercholesterolemic diet. The Trim21-/-->Ldlr-/- mice developed larger atherosclerotic plaques, with significantly higher collagen content compared to mice transplanted with wild-type cells. High collagen content of the atheroma is stabilizing, and has recently been linked to IL-17. Interestingly, Trim21-/-->Ldlr-/- mice had elevated CD4 and IL-17 mRNA expression in plaques, and increased numbers of activated CD4+ T cells in the periphery. An increased differentiation of naïve T cells lacking Trim21 into Th17 cells was confirmed in vitro, with transcriptomic analysis revealing upregulation of genes of a non-pathogenic Th17 phenotype. Also, decreased expression of matrix metalloproteinases (MMPs) was noted in aortic plaques. Analysis of human carotid plaques confirmed that TRIM21 expression negatively correlates with the expression of key Th17 genes and collagen, but positively to MMPs also in patients, linking our findings to a clinical setting.ConclusionIn this study, we demonstrate that TRIM21 influences atherosclerosis via regulation of Th17 responses, with TRIM21 deficiency promoting IL-17 expression and a more fibrous, stable, phenotype of the plaques.

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Jiang, XT (författare)
  • Thorlacius, GEKarolinska Institutet (författare)
  • Lundberg, AM (författare)
  • Ostberg, T (författare)
  • Yan, ZQ (författare)
  • Kuchroo, VK (författare)
  • Hansson, GKKarolinska Institutet (författare)
  • Wahren-Herlenius, MKarolinska Institutet (författare)
  • Karolinska Institutet (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Cardiovascular research: Oxford University Press (OUP)114:1, s. 158-1671755-32450008-6363

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