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- Adori, MKarolinska Institutet (author)
Altered Marginal Zone B Cell Selection in the Absence of IκBNS
- Article/chapterEnglish2018
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- 2018-01-15
- The American Association of Immunologists,2018
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- LIBRIS-ID:oai:prod.swepub.kib.ki.se:137403810
- http://kipublications.ki.se/Default.aspx?queryparsed=id:137403810URI
- https://doi.org/10.4049/jimmunol.1700791DOI
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- Language:English
- Summary in:English
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- Marginal zone (MZ) B cells reside in the splenic MZ and play important roles in T cell–independent humoral immune responses against blood-borne pathogens. IκBNS-deficient bumble mice exhibit a severe reduction in the MZ B compartment but regain an MZ B population with age and, thus, represent a valuable model to examine the biology of MZ B cells. In this article, we characterized the MZ B cell defect in further detail and investigated the nature of the B cells that appear in the MZ of aged bumble mice. Flow cytometry analysis of the splenic transitional B cell subsets demonstrated that MZ B cell development was blocked at the transitional-1 to transitional-2–MZ precursor stage in the absence of functional IκBNS. Immunohistochemical analysis of spleen sections from wild-type and bumble mice revealed no alteration in the cellular MZ microenvironment, and analysis of bone marrow chimeras indicated that the MZ B cell development defect in bumble mice was B cell intrinsic. Further, we demonstrate that the B cells that repopulate the MZ in aged bumble mice were distinct from age-matched wild-type MZ B cells. Specifically, the expression of surface markers characteristic for MZ B cells was altered and the L chain Igλ+ repertoire was reduced in bumble mice. Finally, plasma cell differentiation of sorted LPS-stimulated MZ B cells was impaired, and aged bumble mice were unable to respond to NP-Ficoll immunization. These results demonstrate that IκBNS is required for an intact MZ B cell compartment in C57BL/6 mice.
Added entries (persons, corporate bodies, meetings, titles ...)
- Pedersen, GK (author)
- Adori, C (author)
- Erikson, EKarolinska Institutet (author)
- Khoenkhoen, SKarolinska Institutet (author)
- Stark, JMKarolinska Institutet (author)
- Choi, JH (author)
- Dosenovic, PKarolinska Institutet (author)
- Karlsson, MCIKarolinska Institutet (author)
- Beutler, B (author)
- Hedestam, GBKKarolinska Institutet (author)
- Karolinska Institutet (creator_code:org_t)
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- In:Journal of immunology (Baltimore, Md. : 1950): The American Association of Immunologists200:2, s. 775-7871550-66060022-1767
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- Choi, JH
- Dosenovic, P
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