Sökning: id:"swepub:oai:prod.swepub.kib.ki.se:138391840" >
Immunization with H...
Immunization with HER2 extracellular subdomain proteins induces cellular response and tumor growth inhibition in mice
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
-
LIBRIS-ID:oai:prod.swepub.kib.ki.se:138391840
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:138391840URI
-
https://doi.org/10.2217/imt-2017-0181DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
Aim: We investigated cellular and protective immune responses in mice vaccinated with recombinant HER2 extracellular subdomains. Materials & methods: Balb/C mice were immunized with recombinant full HER2 extracellular domain and subdomain proteins. Humoral and cellular immune response and antitumor effect was evaluated using a syngeneic mice tumor model. Results: All recombinant proteins induced secretion of IL-4 and particularly IFN-γ and IL-17 cytokines. Challenging of immunized mice with stable 4T1-HER2 transfected cells resulted in partial but significant tumor growth inhibition in all groups of mice particularly those immunized with fHER2-ECD together with CPG. Conclusion: Our results suggest that the recombinant HER2-ECD subdomains induce mainly Th1 and Th17 responses, which seem to contribute to tumor growth inhibition in syngeneic mice.
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Sadri-Ardalani, F
(författare)
-
Amiri, MM
(författare)
-
Jeddi-Tehrani, MKarolinska Institutet
(författare)
-
Shabani, M
(författare)
-
Shokri, F
(författare)
-
Karolinska Institutet
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Immunotherapy: Future Medicine Ltd10:6, s. 511-5241750-74481750-743X
Internetlänk
Hitta via bibliotek
Till lärosätets databas