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Oncological outcome...
Oncological outcomes, quality of life outcomes and complications of partial cystectomy for selected cases of muscle-invasive bladder cancer
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
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2018-05-30
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Springer Science and Business Media LLC,2018
Nummerbeteckningar
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:138412233
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http://kipublications.ki.se/Default.aspx?queryparsed=id:138412233URI
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https://doi.org/10.1038/s41598-018-26089-xDOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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To evaluate the oncological results, associated complications, and postoperative health-related quality of life (HR-QoL) in patients treated with partial cystectomy (PC) for muscle-invasive bladder cancer (MIBC). 27 patients who underwent open PC for cT2 MIBC were included. A simple Cox’s proportional hazards regression model was used to assess the association of several potential prognostic factors with survival. Postoperative HR-QoL was assessed with the EORTC (European Organisation for the Research and Treatment of Cancer) QLQ-C30 questionnaire version 3.0. Final pathological tumour stages in PC specimen were: pT0: 18.5%, non-MIBC: 3.7%, MIBC: 74.1%, pCIS: 14.8%. Estimated 5-year overall- and progression-free survival rates were 53.7% and 62.1%. Five (18.5%) patients experienced local recurrence with MIBC. Overall, the salvage cystectomy rate was 18.5%. The 90-day mortality rate was 0%. Significant risk factors for progression-free survival were vascular invasion (HR 5.33) and tumour multilocularity (HR 4.5) in the PC specimen, and a ureteric reimplantation during PC (HR 4.53). The rates of intraoperative complications, 30- and 90-day major complications were 7.4%, respectively and 14.8% for overall long-term complications. Postoperatively, median (IQR) global health status and QoL in our PC cohort was 79.2 (52.1–97.9). Open PC can provide adequate cancer control of MIBC with good HR-QoL in highly selected cases. Open PC can lead to long-term bladder preservation and shows an acceptable rate of severe perioperative complications, even in highly comorbid patients.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Heckmann, RC
(författare)
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Collins, JW
(författare)
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Miller, K
(författare)
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Erber, B
(författare)
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Friedersdorff, F
(författare)
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Fuller, TF
(författare)
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Busch, J
(författare)
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Seifert, HH
(författare)
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Ardelt, P
(författare)
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Wetterauer, C
(författare)
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Hosseini, A
(författare)
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Jentzmik, F
(författare)
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Kempkensteffen, C
(författare)
Sammanhörande titlar
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Ingår i:Scientific reports: Springer Science and Business Media LLC8:1, s. 8360-2045-2322
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Till lärosätets databas
- Av författaren/redakt...
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Ebbing, J
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Heckmann, RC
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Collins, JW
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Miller, K
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Erber, B
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Friedersdorff, F
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visa fler...
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Fuller, TF
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Busch, J
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Seifert, HH
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Ardelt, P
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Wetterauer, C
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Hosseini, A
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Jentzmik, F
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Kempkensteffen, ...
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visa färre...
- Artiklar i publikationen
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Scientific repor ...
- Av lärosätet
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Karolinska Institutet