Search: WFRF:(Karajamaki A.)
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A Genome-Wide Assoc...
A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes
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- van Zuydam, NR (author)
- University of Oxford
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- Ahlqvist, Emma (author)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups
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Sandholm, N (author)
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Deshmukh, H (author)
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Rayner, NW (author)
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Abdalla, M (author)
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- Ladenvall, Claes (author)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups
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Ziemek, D (author)
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Fauman, E (author)
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Robertson, NR (author)
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McKeigue, PM (author)
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Valo, E (author)
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Forsblom, C (author)
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Harjutsalo, V (author)
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Perna, A (author)
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Rurali, E (author)
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Marcovecchio, ML (author)
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Igo, RP (author)
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Salem, RM (author)
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Perico, N (author)
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Lajer, M (author)
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Karajamaki, A (author)
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- Imamura, M (author)
- NIHR Biomedical Research Centre, Oxford,University of Oxford
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Kubo, M (author)
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Takahashi, A (author)
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Sim, XL (author)
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Liu, JJ (author)
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van Dam, RM (author)
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Jiang, GZ (author)
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- Tuomi, Tiinamaija (author)
- Folkhälsan Research Center,Helsinki University Central Hospital,University of Helsinki
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Luk, AOY (author)
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Lee, HM (author)
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Lim, CKP (author)
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Szeto, CC (author)
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So, WY (author)
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Chan, JCN (author)
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Ang, SF (author)
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Dorajoo, R (author)
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Wang, L (author)
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Clara, TSH (author)
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McKnight, AJ (author)
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Duffy, S (author)
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Pezzolesi, MG (author)
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- Orho-Melander, Marju (author)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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Gyorgy, B (author)
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Hadjadj, S (author)
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Hiraki, LT (author)
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Ahluwalia, TS (author)
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- Almgren, Peter (author)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Diabetes - kardiovaskulär sjukdom,Translational Muscle Research,Lund University Research Groups,Diabetes - Cardiovascular Disease
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- Schulz, Christina-Alexandra (author)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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Orho-Melander, M (author)
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Linneberg, A (author)
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- Groop, Leif C (author)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Institute for Molecular Medicine Finland (FIMM)
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Witte, DR (author)
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Grarup, N (author)
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Brandslund, I (author)
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- Melander, Olle (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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Paterson, AD (author)
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Tregouet, D (author)
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Maxwell, AP (author)
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Lim, SC (author)
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Ma, RCW (author)
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Tai, ES (author)
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Maeda, S (author)
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- Lyssenko, Valeriya (author)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,University of Bergen
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Tuomi, T (author)
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Krolewski, AS (author)
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Rich, SS (author)
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Hirschhorn, JN (author)
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Florez, JC (author)
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Dunger, D (author)
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Pedersen, O (author)
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Hansen, T (author)
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Rossing, P (author)
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Remuzzi, G (author)
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Brosnan, MJ (author)
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Palmer, CNA (author)
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Groop, PH (author)
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Colhoun, HM (author)
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Groop, LC (author)
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McCarthy, MI (author)
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- Gomez, Maria F (author)
- Lund University,Lunds universitet,Diabetiska komplikationer,Forskargrupper vid Lunds universitet,Diabetic Complications,Lund University Research Groups
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- Kravic, Jasmina (creator_code:cre_t)
- Lund University,Lunds universitet,Diabetiska komplikationer,Forskargrupper vid Lunds universitet,Diabetic Complications,Lund University Research Groups
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(creator_code:org_t)
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- 2018-04-27
- 2018
- English.
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In: Diabetes. - : American Diabetes Association. - 1939-327X .- 0012-1797. ; 67:7, s. 1414-1427
- Related links:
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https://diabetes.dia...
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http://dx.doi.org/10...
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http://kipublication...
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https://doi.org/10.2...
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https://lup.lub.lu.s...
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Abstract
Subject headings
Close
- Identification of sequence variants robustly associated with predisposition to diabetic kidney disease (DKD) has the potential to provide insights into the pathophysiological mechanisms responsible. We conducted a genome-wide association study (GWAS) of DKD in type 2 diabetes (T2D) using eight complementary dichotomous and quantitative DKD phenotypes: the principal dichotomous analysis involved 5,717 T2D subjects, 3,345 with DKD. Promising association signals were evaluated in up to 26,827 subjects with T2D (12,710 with DKD). A combined T1D+T2D GWAS was performed using complementary data available for subjects with T1D, which, with replication samples, involved up to 40,340 subjects with diabetes (18,582 with DKD). Analysis of specific DKD phenotypes identified a novel signal near GABRR1 (rs9942471, P = 4.5 × 10−8) associated with microalbuminuria in European T2D case subjects. However, no replication of this signal was observed in Asian subjects with T2D or in the equivalent T1D analysis. There was only limited support, in this substantially enlarged analysis, for association at previously reported DKD signals, except for those at UMOD and PRKAG2, both associated with estimated glomerular filtration rate. We conclude that, despite challenges in addressing phenotypic heterogeneity, access to increased sample sizes will continue to provide more robust inference regarding risk variant discovery for DKD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Adult
- Aged
- Aged, 80 and over
- Case-Control Studies
- Diabetes Mellitus, Type 2/complications
- Diabetic Nephropathies/epidemiology
- Female
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Kidney Failure, Chronic/complications
- Male
- Middle Aged
- Polymorphism, Single Nucleotide
- Renal Insufficiency, Chronic/complications
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
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Diabetes
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
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van Zuydam, NR
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Ahlqvist, Emma
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Sandholm, N
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Deshmukh, H
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Rayner, NW
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Abdalla, M
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show more...
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Ladenvall, Claes
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Ziemek, D
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Fauman, E
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Robertson, NR
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McKeigue, PM
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Valo, E
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Forsblom, C
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Harjutsalo, V
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Perna, A
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Rurali, E
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Marcovecchio, ML
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Igo, RP
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Salem, RM
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Perico, N
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Lajer, M
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Karajamaki, A
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Imamura, M
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Kubo, M
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Takahashi, A
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Sim, XL
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Liu, JJ
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van Dam, RM
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Jiang, GZ
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Tuomi, Tiinamaij ...
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Luk, AOY
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Lee, HM
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Lim, CKP
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Szeto, CC
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So, WY
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Chan, JCN
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Ang, SF
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Dorajoo, R
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Wang, L
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Clara, TSH
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McKnight, AJ
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Duffy, S
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Pezzolesi, MG
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Orho-Melander, M ...
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Gyorgy, B
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Hadjadj, S
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Hiraki, LT
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Ahluwalia, TS
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Almgren, Peter
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Schulz, Christin ...
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Orho-Melander, M
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Linneberg, A
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Groop, Leif C
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Witte, DR
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Grarup, N
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Brandslund, I
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Melander, Olle
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Paterson, AD
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Tregouet, D
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Maxwell, AP
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Lim, SC
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Ma, RCW
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Tai, ES
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Maeda, S
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Lyssenko, Valeri ...
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Tuomi, T
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Krolewski, AS
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Rich, SS
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Hirschhorn, JN
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Florez, JC
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Dunger, D
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Pedersen, O
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Hansen, T
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Rossing, P
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Remuzzi, G
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Brosnan, MJ
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Palmer, CNA
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Groop, PH
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Colhoun, HM
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Groop, LC
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McCarthy, MI
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Gomez, Maria F
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Kravic, Jasmina
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Diabetes
- By the university
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Karolinska Institutet
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Lund University