Sökning: (WFRF:(Dakhli H))
> (2018) >
Anticancer chemothe...
Anticancer chemotherapy and radiotherapy trigger both non-cell-autonomous and cell-autonomous death
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
-
2018-06-18
-
Springer Science and Business Media LLC,2018
Nummerbeteckningar
-
LIBRIS-ID:oai:prod.swepub.kib.ki.se:138611283
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:138611283URI
-
https://doi.org/10.1038/s41419-018-0747-yDOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
Even though cell death modalities elicited by anticancer chemotherapy and radiotherapy have been extensively studied, the ability of anticancer treatments to induce non-cell-autonomous death has never been investigated. By means of multispectral imaging flow-cytometry-based technology, we analyzed the lethal fate of cancer cells that were treated with conventional anticancer agents and co-cultured with untreated cells, observing that anticancer agents can simultaneously trigger cell-autonomous and non-cell-autonomous death in treated and untreated cells. After ionizing radiation, oxaliplatin, or cisplatin treatment, fractions of treated cancer cell populations were eliminated through cell-autonomous death mechanisms, while other fractions of the treated cancer cells engulfed and killed neighboring cells through non-cell-autonomous processes, including cellular cannibalism. Under conditions of treatment with paclitaxel, non-cell-autonomous and cell-autonomous death were both detected in the treated cell population, while untreated neighboring cells exhibited features of apoptotic demise. The transcriptional activity of p53 tumor-suppressor protein contributed to the execution of cell-autonomous death, yet failed to affect the non-cell-autonomous death by cannibalism for the majority of tested anticancer agents, indicating that the induction of non-cell-autonomous death can occur under conditions in which cell-autonomous death was impaired. Altogether, these results reveal that chemotherapy and radiotherapy can induce both non-cell-autonomous and cell-autonomous death of cancer cells, highlighting the heterogeneity of cell death responses to anticancer treatments and the unsuspected potential contribution of non-cell-autonomous death to the global effects of anticancer treatment.
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Raza, SQ
(författare)
-
Voisin, L
(författare)
-
Dakhli, H
(författare)
-
Allouch, A
(författare)
-
Law, F
(författare)
-
Sabino, D
(författare)
-
De Jong, D
(författare)
-
Thoreau, M
(författare)
-
Mintet, E
(författare)
-
Dugue, D
(författare)
-
Piacentini, M
(författare)
-
Gougeon, ML
(författare)
-
Jaulin, F
(författare)
-
Bertrand, P
(författare)
-
Brenner, C
(författare)
-
Ojcius, DM
(författare)
-
Kroemer, G
(författare)
-
Modjtahedi, N
(författare)
-
Deutsch, E
(författare)
-
Perfettini, JL
(författare)
Sammanhörande titlar
-
Ingår i:Cell death & disease: Springer Science and Business Media LLC9:7, s. 716-2041-4889
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Martins, I
-
Raza, SQ
-
Voisin, L
-
Dakhli, H
-
Allouch, A
-
Law, F
-
visa fler...
-
Sabino, D
-
De Jong, D
-
Thoreau, M
-
Mintet, E
-
Dugue, D
-
Piacentini, M
-
Gougeon, ML
-
Jaulin, F
-
Bertrand, P
-
Brenner, C
-
Ojcius, DM
-
Kroemer, G
-
Modjtahedi, N
-
Deutsch, E
-
Perfettini, JL
-
visa färre...
- Artiklar i publikationen
-
Cell death & dis ...
- Av lärosätet
-
Karolinska Institutet