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JAZF1 ameliorates a...
JAZF1 ameliorates age and diet-associated hepatic steatosis through SREBP-1c -dependent mechanism
- Article/chapterEnglish2018
Publisher, publication year, extent ...
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2018-08-28
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Springer Science and Business Media LLC,2018
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:139003894
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http://kipublications.ki.se/Default.aspx?queryparsed=id:139003894URI
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https://doi.org/10.1038/s41419-018-0923-0DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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JAZF zinc finger 1 (JAZF1) is involved in glucose and lipid metabolisms. However, its role in aging- and nutrient-related hepatic steatosis is unclear. In the current study, we demonstrated that JAZF1 expression was markedly down-regulated in obesity-associated mice and nonalcoholic fatty liver disease (NAFLD) patients. During aging, JAZF1 expression was gradually down-regulated in both C57BL/6 J and JAZF1-Tg mice. In JAZF1-Tg mice, body fat content and hepatosteatosis were protected from HFD-induced steatosis, and accompanied by decreased lipogenesis gene expression. The inhibitory effects of hepatic steatosis in JAZF1-Tg mice, however, were disappeared during aging. In hepatocytes, over-expression of JAZF1 attenuated, while knockdown of JAZF1 enhanced the expression of lipogenesis genes. The over-expressing of JAZF1 in hepatocytes displayed the increased adenosine monophosphate-activated protein kinase (AMPK) phosphorylation and decreased sterol regulatory element-binding protein 1c (SREBP-1c) expression. The roles of JAZF1 were partially attenuated by Compound C. Mechanistically, JAZF1 suppressed SREBP-1c expression through the inhibition of transcriptional activity of liver X receptor response elements (LXREs) in the SREBP-1c promoter. Data illustrate that JAZF1 may have a crucial role in the regulation of age and nutrient-associated hepatosteatosis through an AMPK/SREBP-1c-dependent mechanism.
Added entries (persons, corporate bodies, meetings, titles ...)
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Zhou, BY
(author)
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Yang, GY
(author)
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Hu, WJ
(author)
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Zhang, LL
(author)
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Liu, R
(author)
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Li, MY
(author)
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Wang, K
(author)
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Gu, HF
(author)
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Guan, YF
(author)
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Zhu, ZM
(author)
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Zheng, HT
(author)
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Peng, J
(author)
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Li, L
(author)
Related titles
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In:Cell death & disease: Springer Science and Business Media LLC9:9, s. 859-2041-4889
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Wei, Q
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Zhou, BY
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Yang, GY
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Hu, WJ
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Zhang, LL
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Liu, R
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Li, MY
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Wang, K
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Gu, HF
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Guan, YF
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Zhu, ZM
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Zheng, HT
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Peng, J
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Li, L
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Cell death & dis ...
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Karolinska Institutet