Identification of nine new susceptibility loci for endometrial cancer

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MARC

O'Mara, TAQIMR Berghofer Medical Research Institute (author)

Identification of nine new susceptibility loci for endometrial cancer

Article/chapterEnglish2018

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2018-08-09
Springer Science and Business Media LLC,2018

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LIBRIS-ID:oai:prod.swepub.kib.ki.se:139028587
http://kipublications.ki.se/Default.aspx?queryparsed=id:139028587URI
https://doi.org/10.1038/s41467-018-05427-7DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-368158URI
https://lup.lub.lu.se/record/9b22f688-0605-4a6c-a1c4-ea27adeb923fURI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Endometrial cancer is the most commonly diagnosed cancer of the female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial cancer. Here, we present an expanded meta-analysis of 12,906 endometrial cancer cases and 108,979 controls (including new genotype data for 5624 cases) and identify nine novel genome-wide significant loci, including a locus on 12q24.12 previously identified by meta-GWAS of endometrial and colorectal cancer. At five loci, expression quantitative trait locus (eQTL) analyses identify candidate causal genes; risk alleles at two of these loci associate with decreased expression of genes, which encode negative regulators of oncogenic signal transduction proteins (SH2B3 (12q24.12) and NF1 (17q11.2)). In summary, this study has doubled the number of known endometrial cancer risk loci and revealed candidate causal genes for future study.

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Glubb, DM (author)
Amant, F (author)
Annibali, D (author)
Ashton, K (author)
Attia, J (author)
Auer, PL (author)
Beckmann, MW (author)
Black, A (author)
Bolla, MK (author)
Brauch, H (author)
Brenner, H (author)
Brinton, L (author)
Buchanan, DD (author)
Burwinkel, B (author)
Chang-Claude, J (author)
Chanock, SJ (author)
Chen, C (author)
Chen, MM (author)
Cheng, THT (author)
Clarke, CL (author)
Clendenning, M (author)
Cook, LS (author)
Couch, FJ (author)
Cox, A (author)
Crous-Bous, M (author)
Czene, KKarolinska Institutet (author)
Day, F (author)
Dennis, J (author)
Depreeuw, J (author)
Doherty, JA (author)
Dork, T (author)
Dowdy, SC (author)
Durst, M (author)
Ekici, AB (author)
Fasching, PA (author)
Fridley, BL (author)
Friedenreich, CM (author)
Fritschi, L (author)
Fung, J (author)
Garcia-Closas, M (author)
Gaudet, MM (author)
Giles, GG (author)
Goode, EL (author)
Gorman, M (author)
Haiman, CA (author)
Hall, PKarolinska Institutet (author)
Hankison, SE (author)
Healey, CS (author)
Hein, A (author)
Hillemanns, P (author)
Hodgson, S (author)
Hoivik, EA (author)
Holliday, EG (author)
Hopper, JL (author)
Hunter, DJ (author)
Jones, A (author)
Krakstad, C (author)
Kristensen, VN (author)
Lambrechts, D (author)
Le Marchand, L (author)
Liang, XL (author)
Lindblom, AKarolinska Institutet (author)
Lissowska, J (author)
Long, JR (author)
Lu, LG (author)
Magliocco, AM (author)
Martin, L (author)
McEvoy, M (author)
Meindl, A (author)
Michailidou, K (author)
Milne, RL (author)
Mints, MKarolinska Institutet (author)
Montgomery, GW (author)
Nassir, R (author)
Olsson, HåkanLund University,Lunds universitet,Lunds Melanomstudiegrupp,Forskargrupper vid Lunds universitet,Lund Melanoma Study Group,Lund University Research Groups(Swepub:lu)onk-hol (author)
Orlow, I (author)
Otton, G (author)
Palles, C (author)
Perry, JRB (author)
Peto, J (author)
Pooler, L (author)
Prescott, J (author)
Proietto, T (author)
Rebbeck, TR (author)
Risch, HA (author)
Wolk, AlicjaUppsala universitet,Ortopedi(Swepub:uu)alwol516 (author)
Rubner, M (author)
Runnebaum, I (author)
Sacerdote, C (author)
Sarto, GE (author)
Schumacher, F (author)
Scott, RJ (author)
Setiawan, VW (author)
Shah, M (author)
Sheng, X (author)
Shu, XO (author)
Southey, MC (author)
Swerdlow, AJ (author)
Tham, EKarolinska Institutet (author)
Trovik, J (author)
Turman, C (author)
Tyrer, JP (author)
Vachon, C (author)
Vanden Berg, D (author)
Vanderstichele, A (author)
Wang, ZM (author)
Webb, PM (author)
Wentzensen, N (author)
Werner, HMJ (author)
Winham, SJ (author)
Wolk, AKarolinska Institutet (author)
Xia, L (author)
Xiang, YB (author)
Yang, HP (author)
Yu, H (author)
Zheng, W (author)
Pharoah, PDP (author)
Dunning, AM (author)
Kraft, P (author)
De Vivo, I (author)
Tomlinson, I (author)
Easton, DF (author)
Spurdle, AB (author)
Thompson, DJUniversity of Cambridge (author)
Karolinska InstitutetQIMR Berghofer Medical Research Institute (creator_code:org_t)

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In:Nature communications: Springer Science and Business Media LLC9:1, s. 3166-2041-1723

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By the author/editor: O'Mara, TA; Glubb, DM; Amant, F; Annibali, D; Ashton, K; Attia, J; show more...; Auer, PL; Beckmann, MW; Black, A; Bolla, MK; Brauch, H; Brenner, H; Brinton, L; Buchanan, DD; Burwinkel, B; Chang-Claude, J; Chanock, SJ; Chen, C; Chen, MM; Cheng, THT; Clarke, CL; Clendenning, M; Cook, LS; Couch, FJ; Cox, A; Crous-Bous, M; Czene, K; Day, F; Dennis, J; Depreeuw, J; Doherty, JA; Dork, T; Dowdy, SC; Durst, M; Ekici, AB; Fasching, PA; Fridley, BL; Friedenreich, CM; Fritschi, L; Fung, J; Garcia-Closas, M; Gaudet, MM; Giles, GG; Goode, EL; Gorman, M; Haiman, CA; Hall, P; Hankison, SE; Healey, CS; Hein, A; Hillemanns, P; Hodgson, S; Hoivik, EA; Holliday, EG; Hopper, JL; Hunter, DJ; Jones, A; Krakstad, C; Kristensen, VN; Lambrechts, D; Le Marchand, L; Liang, XL; Lindblom, A; Lissowska, J; Long, JR; Lu, LG; Magliocco, AM; Martin, L; McEvoy, M; Meindl, A; Michailidou, K; Milne, RL; Mints, M; Montgomery, GW; Nassir, R; Olsson, Håkan; Orlow, I; Otton, G; Palles, C; Perry, JRB; Peto, J; Pooler, L; Prescott, J; Proietto, T; Rebbeck, TR; Risch, HA; Wolk, Alicja; Rubner, M; Runnebaum, I; Sacerdote, C; Sarto, GE; Schumacher, F; Scott, RJ; Setiawan, VW; Shah, M; Sheng, X; Shu, XO; Southey, MC; Swerdlow, AJ; Tham, E; Trovik, J; Turman, C; Tyrer, JP; Vachon, C; Vanden Berg, D; Vanderstichele, ...; Wang, ZM; Webb, PM; Wentzensen, N; Werner, HMJ; Winham, SJ; Wolk, A; Xia, L; Xiang, YB; Yang, HP; Yu, H; Zheng, W; Pharoah, PDP; Dunning, AM; Kraft, P; De Vivo, I; Tomlinson, I; Easton, DF; Spurdle, AB; Thompson, DJ; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Medical Genetics

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