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  • Kim, Jong HyukUniv Minnesota, Anim Canc Care & Res Program, St Paul, MN USA.;Univ Minnesota, Coll Vet Med, Dept Vet Clin Sci, St Paul, MN USA.;Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN USA.;Univ Florida, Coll Vet Med, Dept Small Anim Clin Sci, Gainesville, FL USA.;Univ Florida, Hlth Canc Ctr, Gainesville, FL USA.;Univ Florida, Intelligent Crit Care Ctr, Gainesville, FL USA.;Univ Florida, Artificial Intelligence Acad Initiat AI2 Ctr, Gainesville, FL USA. (författare)

Hemangiosarcoma Cells Promote Conserved Host-derived Hematopoietic Expansion

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • American Association For Cancer Research (AACR),2024
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-535868
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-535868URI
  • https://doi.org/10.1158/2767-9764.CRC-23-0441DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Hemangiosarcoma and angiosarcoma are soft-tissue sarcomas of blood vessel-forming cells in dogs and humans, respectively. These vasoformative sarcomas are aggressive and highly metastatic, with disorganized, irregular blood-filled vascular spaces. Our objective was to define molecular programs which support the niche that enables progression of canine hemangiosarcoma and human angiosarcoma. Dog-in-mouse hemangiosarcoma xenografts recapitulated the vasoformative and highly angiogenic morphology and molecular characteristics of primary tumors. Blood vessels in the tumors were complex and disorganized, and they were lined by both donor and host cells. In a series of xenografts, we observed that the transplanted hemangiosarcoma cells created exuberant myeloid hyperplasia and gave rise to lymphoproliferative tumors of mouse origin. Our functional analyses indicate that hemangiosarcoma cells generate a microenvironment that supports expansion and differentiation of hematopoietic progenitor populations. Furthermore, gene expression profiling data revealed hemangiosarcoma cells expressed a repertoire of hematopoietic cytokines capable of regulating the surrounding stromal cells. We conclude that canine hemangiosarcomas, and possibly human angiosarcomas, maintain molecular properties that provide hematopoietic support and facilitate stromal reactions, suggesting their potential involvement in promoting the growth of hematopoietic tumors.Significance: We demonstrate that hemangiosarcomas regulate molecular programs supporting hematopoietic expansion and differentiation, providing insights into their potential roles in creating a permissive stromal-immune environment for tumor progression.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Schulte, Ashley J.Univ Minnesota, Anim Canc Care & Res Program, St Paul, MN USA.;Univ Minnesota, Coll Vet Med, Dept Vet Clin Sci, St Paul, MN USA.;Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN USA. (författare)
  • Sarver, Aaron L.Univ Minnesota, Anim Canc Care & Res Program, St Paul, MN USA.;Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN USA.;Univ Minnesota, Inst Hlth Informat, Minneapolis, MN USA. (författare)
  • Lee, DongheeUniv Florida, Coll Vet Med, Dept Small Anim Clin Sci, Gainesville, FL USA. (författare)
  • Angelos, Mathew G.Univ Minnesota, Stem Cell Inst, Minneapolis, MN USA.;Univ Minnesota, Med Sch, Dept Med, Div Hematol Oncol & Transplantat, Minneapolis, MN USA.;Univ Minnesota, Microbiol Immunol & Canc Biol MICaB Grad Program, Minneapolis, MN USA.;Univ Penn, Sch Med, Dept Med, Div Hematol & Oncol, Philadelphia, PA USA. (författare)
  • Frantz, Aric M.Univ Minnesota, Anim Canc Care & Res Program, St Paul, MN USA.;Univ Minnesota, Coll Vet Med, Dept Vet Clin Sci, St Paul, MN USA.;Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN USA.;Capstan Therapeut, San Diego, CA USA. (författare)
  • Forster, Colleen L.Univ Minnesota, Biol Mat Procurement Network BioNet, Minneapolis, MN USA. (författare)
  • O'Brien, Timothy D.Univ Minnesota, Anim Canc Care & Res Program, St Paul, MN USA.;Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN USA.;Univ Minnesota, Stem Cell Inst, Minneapolis, MN USA.;Univ Minnesota, Coll Vet Med, Dept Vet Populat Med, St Paul, MN USA. (författare)
  • Cornax, IngridUniv Minnesota, Anim Canc Care & Res Program, St Paul, MN USA.;Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN USA.;Univ Minnesota, Coll Vet Med, Dept Vet Populat Med, St Paul, MN USA.;Janssen Res & Dev LLC, Horsham, PA USA. (författare)
  • O'Sullivan, M. GerardUniv Minnesota, Anim Canc Care & Res Program, St Paul, MN USA.;Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN USA.;Univ Minnesota, Coll Vet Med, Dept Vet Populat Med, St Paul, MN USA. (författare)
  • Cheng, NuojinUniv Minnesota, Coll Sci & Engn, Sch Math, Minneapolis, MN USA.;Univ Colorado, Appl Math, Boulder, CO USA. (författare)
  • Lewellen, MitziUniv Minnesota, Anim Canc Care & Res Program, St Paul, MN USA.;Univ Minnesota, Coll Vet Med, Dept Vet Clin Sci, St Paul, MN USA.;Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN USA. (författare)
  • Oseth, LeAnnUniv Minnesota, Masonic Canc Ctr, Minneapolis, MN USA. (författare)
  • Kumar, SunilUniv Minnesota, Coll Vet Med, Dept Vet Populat Med, St Paul, MN USA. (författare)
  • Bullman, SusanBroad Inst MIT & Harvard, Cambridge, MA USA.;Fred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA USA. (författare)
  • Pedamallu, Chandra SekharBroad Inst MIT & Harvard, Cambridge, MA USA.;Dana Farber Canc Inst, Dept Med Oncol, Boston, MA USA.;Harvard Med Sch, Boston, MA USA. (författare)
  • Goyal, Sagar M.Univ Minnesota, Coll Vet Med, Dept Vet Populat Med, St Paul, MN USA. (författare)
  • Meyerson, MatthewBroad Inst MIT & Harvard, Cambridge, MA USA.;Dana Farber Canc Inst, Dept Med Oncol, Boston, MA USA.;Harvard Med Sch, Boston, MA USA. (författare)
  • Lund, Troy C.Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN USA.;Univ Minnesota, Med Sch, Dept Pediat, Minneapolis, MN USA. (författare)
  • Breen, MatthewNorth Carolina State Univ, Coll Vet Med, Dept Mol Biomed Sci, Raleigh, NC USA.;North Carolina State Univ, Comparat Med Inst, Raleigh, NC USA.;Univ N Carolina, Lineberger Comprehens Canc Ctr, Canc Genet Program, Raleigh, NC USA. (författare)
  • Lindblad-Toh, KerstinUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab,Broad Inst MIT & Harvard, Cambridge, MA USA.(Swepub:uu)kerli865 (författare)
  • Dickerson, Erin B.Univ Minnesota, Anim Canc Care & Res Program, St Paul, MN USA.;Univ Minnesota, Coll Vet Med, Dept Vet Clin Sci, St Paul, MN USA.;Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN USA. (författare)
  • Kaufman, Dan S.Univ Minnesota, Anim Canc Care & Res Program, St Paul, MN USA.;Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN USA.;Univ Minnesota, Stem Cell Inst, Minneapolis, MN USA.;Univ Minnesota, Med Sch, Dept Med, Div Hematol Oncol & Transplantat, Minneapolis, MN USA.;Univ Minnesota, Ctr Immunol, Minneapolis, MN USA.;Univ Calif San Diego, Dept Med, Div Regenerat Med, La Jolla, CA USA. (författare)
  • Modiano, Jaime F.Univ Minnesota, Anim Canc Care & Res Program, St Paul, MN USA.;Univ Minnesota, Coll Vet Med, Dept Vet Clin Sci, St Paul, MN USA.;Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN USA.;Univ Minnesota, Stem Cell Inst, Minneapolis, MN USA.;Univ Minnesota, Ctr Immunol, Minneapolis, MN USA.;Univ Minnesota, Dept Lab Med & Pathol, Med Sch, Minneapolis, MN USA.;Univ Minnesota, Ctr Engn Med, Minneapolis, MN USA. (författare)
  • Univ Minnesota, Anim Canc Care & Res Program, St Paul, MN USA.;Univ Minnesota, Coll Vet Med, Dept Vet Clin Sci, St Paul, MN USA.;Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN USA.;Univ Florida, Coll Vet Med, Dept Small Anim Clin Sci, Gainesville, FL USA.;Univ Florida, Hlth Canc Ctr, Gainesville, FL USA.;Univ Florida, Intelligent Crit Care Ctr, Gainesville, FL USA.;Univ Florida, Artificial Intelligence Acad Initiat AI2 Ctr, Gainesville, FL USA.Univ Minnesota, Anim Canc Care & Res Program, St Paul, MN USA.;Univ Minnesota, Coll Vet Med, Dept Vet Clin Sci, St Paul, MN USA.;Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN USA. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Cancer Research Communications: American Association For Cancer Research (AACR)4:6, s. 1467-14802767-9764

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