Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

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MARC

Kilpelainen, TOUniversity of Copenhagen,Icahn School of Medicine at Mount Sinai (author)

Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

Article/chapterEnglish2019

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2019-01-22
London :Springer Science and Business Media LLC,2019

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LIBRIS-ID:oai:prod.swepub.kib.ki.se:140070864
http://kipublications.ki.se/Default.aspx?queryparsed=id:140070864URI
https://doi.org/10.1038/s41467-018-08008-wDOI
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-156317URI
https://lup.lub.lu.se/record/ddccdd28-505a-425f-bbb9-5250d5206f47URI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We find four loci, in/near CLASP1, LHX1, SNTA1, and CNTNAP2, that are associated with circulating lipid levels through interaction with physical activity; higher levels of physical activity enhance the HDL cholesterol-increasing effects of the CLASP1, LHX1, and SNTA1 loci and attenuate the LDL cholesterol-increasing effect of the CNTNAP2 locus. The CLASP1, LHX1, and SNTA1 regions harbor genes linked to muscle function and lipid metabolism. Our results elucidate the role of physical activity interactions in the genetic contribution to blood lipid levels.

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Bentley, AR (author)
Noordam, R (author)
Sung, YJ (author)
Schwander, K (author)
Winkler, TW (author)
Jakupovic, H (author)
Chasman, DI (author)
Manning, A (author)
Ntalla, I (author)
Aschard, H (author)
Brown, MR (author)
de las Fuentes, LKarolinska Institutet (author)
Franceschini, N (author)
Guo, XQ (author)
Vojinovic, D (author)
Aslibekyan, S (author)
Feitosa, MF (author)
Kho, MKarolinska Institutet (author)
Musani, SK (author)
Richard, M (author)
Wang, HM (author)
Wang, Z (author)
Bartz, TM (author)
Bielak, LF (author)
Campbell, A (author)
Dorajoo, R (author)
Fisher, V (author)
Franks, PaulUmeå University,Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,University of Oxford,Harvard University(Swepub:lu)med-plf (author)
Horimoto, ARVR (author)
Li, CW (author)
Lohman, KK (author)
Marten, J (author)
Sim, XL (author)
Smith, AV (author)
Tajuddin, SM (author)
Alver, M (author)
Amini, M (author)
Boissel, M (author)
Chai, JF (author)
Chen, XKarolinska Institutet (author)
Divers, J (author)
Evangelou, E (author)
Gao, CWashington University in St. Louis (author)
Graff, M (author)
Harris, SE (author)
He, MA (author)
Hsu, FC (author)
Jackson, AU (author)
Zhao, JH (author)
Kraja, AT (author)
Kuhnel, B (author)
Laguzzi, FKarolinska Institutet (author)
Lyytikainen, LPKarolinska Institutet (author)
Nolte, IM (author)
Rauramaa, R (author)
Riaz, M (author)
Robino, A (author)
Rueedi, R (author)
Stringham, HM (author)
Takeuchi, F (author)
van der Most, PJ (author)
V. Varga, TiborLund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-tv_ (author)
Verweij, N (author)
Ware, EB (author)
Wen, WQ (author)
Li, XY (author)
Yanek, LR (author)
Amin, N (author)
Arnett, DK (author)
Boerwinkle, E (author)
Brumat, M (author)
Cade, B (author)
Canouil, M (author)
Chen, YDI (author)
Concas, MP (author)
Connell, J (author)
de Mutsert, R (author)
de Silva, HJ (author)
de Vries, PS (author)
Demirkan, A (author)
Ding, JZ (author)
Eaton, CB (author)
Faul, JD (author)
Friedlander, Y (author)
Gabriel, KP (author)
Ghanbari, M (author)
Giulianini, F (author)
Gu, CC (author)
Gu, DF (author)
Harris, TB (author)
He, J (author)
Heikkinen, S (author)
Heng, CK (author)
Hunt, SC (author)
Ikram, MA (author)
Jonas, JB (author)
Wennberg, Patrik,1972-Umeå universitet,Allmänmedicin(Swepub:umu)pawe0002 (author)
Komulainen, P (author)
Krieger, JE (author)
Kritchevsky, SB (author)
Kutalik, Z (author)
Kuusisto, J (author)
Langefeld, CD (author)
Langenberg, C (author)
Launer, LJ (author)
Leander, KKarolinska Institutet (author)
Lemaitre, RN (author)
Lewis, CE (author)
Liang, JJ (author)
Alizadeh, BZ (author)
Boezen, HM (author)
Franke, LIcahn School of Medicine at Mount Sinai (author)
Navis, G (author)
Rots, M (author)
Swertz, M (author)
Wolffenbuttel, BHR (author)
Wijmenga, C (author)
Liu, JJ (author)
Magi, R (author)
Manichaikul, A (author)
Meitinger, T (author)
Metspalu, A (author)
Milaneschi, Y (author)
Mohlke, KL (author)
Mosley, TH (author)
Murray, AD (author)
Nalls, MA (author)
Nang, EEK (author)
Nelson, CP (author)
Nona, S (author)
Norris, JM (author)
Nwuba, CV (author)
O'Connell, J (author)
Palmer, ND (author)
Papanicolau, GJ (author)
Pazoki, R (author)
Pedersen, NLKarolinska Institutet (author)
Peters, A (author)
Poveda, AlaitzLund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups(Swepub:lu)med-azp (author)
Polasek, O (author)
Porteous, DJ (author)
Poveda, A (author)
Raitakari, OT (author)
Rich, SS (author)
Risch, N (author)
Robinson, JG (author)
Rose, LM (author)
Rudan, I (author)
Schreiner, PJ (author)
Scott, RA (author)
Sidney, SS (author)
Sims, M (author)
Smith, JA (author)
Snieder, H (author)
Sofer, T (author)
Starr, JM (author)
Sternfeld, B (author)
Strauch, K (author)
Tang, H (author)
Taylor, KD (author)
Tsai, MY (author)
Tuomilehto, J (author)
Uitterlinden, AG (author)
van der Ende, MY (author)
van Heemst, D (author)
Voortman, T (author)
Waldenberger, M (author)
Franks, Paul W.Umeå universitet,Avdelningen för medicin,Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden; Harvard T. H. Chan School of Public Health, Department of Nutrition, Harvard University, Boston, USA; OCDEM, Radcliffe Department of Medicine, University of Oxford, Oxford, UK(Swepub:umu)pafr0003 (author)
Wilson, G (author)
Xiang, YB (author)
Yao, J (author)
Yu, CZ (author)
Yuan, JM (author)
Zhao, W (author)
Zonderman, AB (author)
Becker, DM (author)
Boehnke, M (author)
Bowden, DW (author)
de Faire, UKarolinska Institutet (author)
Deary, IJ (author)
Elliott, P (author)
Esko, T (author)
Freedman, BI (author)
Froguel, P (author)
Gasparini, P (author)
Gieger, C (author)
Kato, N (author)
Laakso, M (author)
Lakka, TA (author)
Lehtimaki, T (author)
Magnusson, PKEKarolinska Institutet (author)
Oldehinkel, AJ (author)
Penninx, BWJH (author)
Samani, NJ (author)
Shu, XO (author)
van der Harst, P (author)
Van Vliet-Ostaptchouk, JV (author)
Vollenweider, P (author)
Wagenknecht, LE (author)
Wang, YX (author)
Wareham, NJ (author)
Weir, DR (author)
Wu, TC (author)
Zheng, W (author)
Zhu, XF (author)
Evans, MK (author)
Franks, PW (author)
Gudnason, V (author)
Hayward, C (author)
Horta, BL (author)
Kelly, TN (author)
Liu, YM (author)
North, KE (author)
Pereira, AC (author)
Ridker, PM (author)
Tai, ES (author)
van Dam, RM (author)
Fox, ER (author)
Kardia, SLR (author)
Liu, CT (author)
Mook-Kanamori, DO (author)
Province, MA (author)
Redline, S (author)
van Duijn, CM (author)
Rotter, JI (author)
Kooperberg, CB (author)
Gauderman, WJ (author)
Psaty, BM (author)
Rice, K (author)
Munroe, PB (author)
Fornage, M (author)
Cupples, LA (author)
Rotimi, CN (author)
Morrison, AC (author)
Rao, DC (author)
Loos, RJF (author)
University of CopenhagenIcahn School of Medicine at Mount Sinai (creator_code:org_t)
et al.

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In:Nature communicationsLondon : Springer Science and Business Media LLC10:1, s. 376-2041-1723

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By the author/editor: Kilpelainen, TO; Bentley, AR; Noordam, R; Sung, YJ; Schwander, K; Winkler, TW; show more...; Jakupovic, H; Chasman, DI; Manning, A; Ntalla, I; Aschard, H; Brown, MR; de las Fuentes, ...; Franceschini, N; Guo, XQ; Vojinovic, D; Aslibekyan, S; Feitosa, MF; Kho, M; Musani, SK; Richard, M; Wang, HM; Wang, Z; Bartz, TM; Bielak, LF; Campbell, A; Dorajoo, R; Fisher, V; Franks, Paul; Horimoto, ARVR; Li, CW; Lohman, KK; Marten, J; Sim, XL; Smith, AV; Tajuddin, SM; Alver, M; Amini, M; Boissel, M; Chai, JF; Chen, X; Divers, J; Evangelou, E; Gao, C; Graff, M; Harris, SE; He, MA; Hsu, FC; Jackson, AU; Zhao, JH; Kraja, AT; Kuhnel, B; Laguzzi, F; Lyytikainen, LP; Nolte, IM; Rauramaa, R; Riaz, M; Robino, A; Rueedi, R; Stringham, HM; Takeuchi, F; van der Most, PJ; V. Varga, Tibor; Verweij, N; Ware, EB; Wen, WQ; Li, XY; Yanek, LR; Amin, N; Arnett, DK; Boerwinkle, E; Brumat, M; Cade, B; Canouil, M; Chen, YDI; Concas, MP; Connell, J; de Mutsert, R; de Silva, HJ; de Vries, PS; Demirkan, A; Ding, JZ; Eaton, CB; Faul, JD; Friedlander, Y; Gabriel, KP; Ghanbari, M; Giulianini, F; Gu, CC; Gu, DF; Harris, TB; He, J; Heikkinen, S; Heng, CK; Hunt, SC; Ikram, MA; Jonas, JB; Wennberg, Patrik ...; Komulainen, P; Krieger, JE; Kritchevsky, SB; Kutalik, Z; Kuusisto, J; Langefeld, CD; Langenberg, C; Launer, LJ; Leander, K; Lemaitre, RN; Lewis, CE; Liang, JJ; Alizadeh, BZ; Boezen, HM; Franke, L; Navis, G; Rots, M; Swertz, M; Wolffenbuttel, B ...; Wijmenga, C; Liu, JJ; Magi, R; Manichaikul, A; Meitinger, T; Metspalu, A; Milaneschi, Y; Mohlke, KL; Mosley, TH; Murray, AD; Nalls, MA; Nang, EEK; Nelson, CP; Nona, S; Norris, JM; Nwuba, CV; O'Connell, J; Palmer, ND; Papanicolau, GJ; Pazoki, R; Pedersen, NL; Peters, A; Poveda, Alaitz; Polasek, O; Porteous, DJ; Poveda, A; Raitakari, OT; Rich, SS; Risch, N; Robinson, JG; Rose, LM; Rudan, I; Schreiner, PJ; Scott, RA; Sidney, SS; Sims, M; Smith, JA; Snieder, H; Sofer, T; Starr, JM; Sternfeld, B; Strauch, K; Tang, H; Taylor, KD; Tsai, MY; Tuomilehto, J; Uitterlinden, AG; van der Ende, MY; van Heemst, D; Voortman, T; Waldenberger, M; Franks, Paul W.; Wilson, G; Xiang, YB; Yao, J; Yu, CZ; Yuan, JM; Zhao, W; Zonderman, AB; Becker, DM; Boehnke, M; Bowden, DW; de Faire, U; Deary, IJ; Elliott, P; Esko, T; Freedman, BI; Froguel, P; Gasparini, P; Gieger, C; Kato, N; Laakso, M; Lakka, TA; Lehtimaki, T; Magnusson, PKE; Oldehinkel, AJ; Penninx, BWJH; Samani, NJ; Shu, XO; van der Harst, P; Van Vliet-Ostapt ...; Vollenweider, P; Wagenknecht, LE; Wang, YX; Wareham, NJ; Weir, DR; Wu, TC; Zheng, W; Zhu, XF; Evans, MK; Franks, PW; Gudnason, V; Hayward, C; Horta, BL; Kelly, TN; Liu, YM; North, KE; Pereira, AC; Ridker, PM; Tai, ES; van Dam, RM; Fox, ER; Kardia, SLR; Liu, CT; Mook-Kanamori, D ...; Province, MA; Redline, S; van Duijn, CM; Rotter, JI; Kooperberg, CB; Gauderman, WJ; Psaty, BM; Rice, K; Munroe, PB; Fornage, M; Cupples, LA; Rotimi, CN; Morrison, AC; Rao, DC; Loos, RJF; show less...

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