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Genome-wide by envi...
Genome-wide by environment interaction studies of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland
- Article/chapterEnglish2019
Publisher, publication year, extent ...
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2019-02-04
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Springer Science and Business Media LLC,2019
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:140403896
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http://kipublications.ki.se/Default.aspx?queryparsed=id:140403896URI
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https://doi.org/10.1038/s41398-018-0360-yDOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Stress is associated with poorer physical and mental health. To improve our understanding of this link, we performed genome-wide association studies (GWAS) of depressive symptoms and genome-wide by environment interaction studies (GWEIS) of depressive symptoms and stressful life events (SLE) in two UK population-based cohorts (Generation Scotland and UK Biobank). No SNP was individually significant in either GWAS, but gene-based tests identified six genes associated with depressive symptoms in UK Biobank (DCC, ACSS3, DRD2, STAG1, FOXP2 and KYNU; p < 2.77 × 10−6). Two SNPs with genome-wide significant GxE effects were identified by GWEIS in Generation Scotland: rs12789145 (53-kb downstream PIWIL4; p = 4.95 × 10−9; total SLE) and rs17070072 (intronic to ZCCHC2; p = 1.46 × 10−8; dependent SLE). A third locus upstream CYLC2 (rs12000047 and rs12005200, p < 2.00 × 10−8; dependent SLE) when the joint effect of the SNP main and GxE effects was considered. GWEIS gene-based tests identified: MTNR1B with GxE effect with dependent SLE in Generation Scotland; and PHF2 with the joint effect in UK Biobank (p < 2.77 × 10−6). Polygenic risk scores (PRSs) analyses incorporating GxE effects improved the prediction of depressive symptom scores, when using weights derived from either the UK Biobank GWAS of depressive symptoms (p = 0.01) or the PGC GWAS of major depressive disorder (p = 5.91 × 10−3). Using an independent sample, PRS derived using GWEIS GxE effects provided evidence of shared aetiologies between depressive symptoms and schizotypal personality, heart disease and COPD. Further such studies are required and may result in improved treatments for depression and other stress-related conditions.
Added entries (persons, corporate bodies, meetings, titles ...)
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Macdonald-Dunlop, E
(author)
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Adams, MJ
(author)
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Clarke, TK
(author)
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MacIntyre, DJ
(author)
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Milburn, K
(author)
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Navrady, L
(author)
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Hayward, C
(author)
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McIntosh, AM
(author)
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Thomson, PA
(author)
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Wray, NR
(author)
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Ripke, S
(author)
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Mattheisen, MKarolinska Institutet
(author)
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Trzaskowski, M
(author)
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Byrne, EM
(author)
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Abdellaoui, A
(author)
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Agerbo, E
(author)
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Air, TM
(author)
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Andlauer, TFM
(author)
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Bacanu, SA
(author)
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Baekvad-Hansen, M
(author)
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Beekman, ATF
(author)
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Bigdeli, TB
(author)
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Binder, EB
(author)
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Blackwood, DHR
(author)
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Bryois, JKarolinska Institutet
(author)
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Buttenscon, HN
(author)
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Bybjerg-Grauholm, J
(author)
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Cai, N
(author)
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Castelao, E
(author)
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Christensen, JH
(author)
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Coleman, JRI
(author)
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Colodro-Conde, L
(author)
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Couvy-Duchesne, B
(author)
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Craddock, N
(author)
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Rawford, GEC
(author)
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Davies, G
(author)
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Deary, IJ
(author)
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Degenhardt, F
(author)
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Derks, EM
(author)
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Direk, N
(author)
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Dolan, CV
(author)
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Dunn, EC
(author)
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Eley, TC
(author)
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Escott-Price, V
(author)
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Kiadeh, FFH
(author)
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Finucane, HK
(author)
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Foo, JC
(author)
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Forstner, AJ
(author)
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Frank, J
(author)
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Gaspar, HA
(author)
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Gill, M
(author)
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Goes, FS
(author)
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Gordon, SD
(author)
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Grove, J
(author)
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Hall, LS
(author)
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Hansen, CS
(author)
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Hansen, TF
(author)
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Herms, S
(author)
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Hickie, IB
(author)
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Hoffmann, P
(author)
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Homuth, G
(author)
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Horn, C
(author)
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Hottenga, JJ
(author)
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Hougaard, DM
(author)
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Ising, M
(author)
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Jansen, R
(author)
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Jones, I
(author)
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Jones, LA
(author)
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Jorgenson, E
(author)
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Knowles, JA
(author)
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Kohane, IS
(author)
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Kraft, J
(author)
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Kretzschmar, WW
(author)
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Krogh, J
(author)
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Kutalik, Z
(author)
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Li, YH
(author)
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Lind, PA
(author)
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Macintyre, DJ
(author)
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MacKinnon, DF
(author)
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Maier, RM
(author)
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Maier, W
(author)
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Marchini, J
(author)
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Mbarek, H
(author)
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McGrath, P
(author)
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McGuffin, P
(author)
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Medland, SE
(author)
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Mehta, D
(author)
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Middeldorp, CM
(author)
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Mihailov, E
(author)
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Milaneschi, Y
(author)
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Milani, L
(author)
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Mondimore, FM
(author)
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Montgomery, GW
(author)
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Mostafavi, S
(author)
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Mullins, N
(author)
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Nauck, M
(author)
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Ng, B
(author)
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Nivard, MG
(author)
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Nyholt, DR
(author)
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O'Reilly, PF
(author)
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Oskarsson, H
(author)
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Owen, MJ
(author)
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Painter, JN
(author)
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Pedersen, CB
(author)
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Pedersen, MG
(author)
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Peterson, RE
(author)
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Pettersson, EKarolinska Institutet
(author)
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Peyrot, WJ
(author)
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Pistis, G
(author)
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Posthuma, D
(author)
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Quiroz, JA
(author)
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Qvist, P
(author)
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Rice, JP
(author)
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Riley, BP
(author)
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Rivera, M
(author)
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Mirza, SS
(author)
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Schoevers, R
(author)
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Schulte, EC
(author)
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Shen, L
(author)
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Shi, JX
(author)
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Shyn, SI
(author)
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Sigurdsson, E
(author)
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Sinnamon, GCB
(author)
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Smit, JH
(author)
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Smith, DJ
(author)
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Stefansson, H
(author)
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Steinberg, S
(author)
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Streit, F
(author)
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Strohmaier, J
(author)
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Tansey, KE
(author)
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Teismann, H
(author)
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Teumer, A
(author)
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Thompson, W
(author)
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Thorgeirsson, TE
(author)
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Traylor, M
(author)
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Treutlein, J
(author)
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Trubetskoy, V
(author)
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Uitterlinden, AG
(author)
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Umbricht, D
(author)
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Van der Auwera, S
(author)
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van Hemert, AM
(author)
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Viktorin, AKarolinska Institutet
(author)
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Visscher, PM
(author)
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Wang, YP
(author)
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Webb, BT
(author)
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Weinsheimer, SM
(author)
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Wellmann, J
(author)
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Willemsen, G
(author)
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Witt, SH
(author)
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Wu, Y
(author)
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Xi, HLS
(author)
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Yang, J
(author)
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Zhang, FT
(author)
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Arolt, V
(author)
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Baune, BT
(author)
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Berger, K
(author)
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Boomsma, DI
(author)
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Cichon, S
(author)
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Dannlowski, U
(author)
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de Geus, EJC
(author)
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DePaulo, JR
(author)
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Domenici, E
(author)
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Domschke, K
(author)
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Esko, T
(author)
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Grabe, HJ
(author)
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Hamilton, SP
(author)
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Heath, AC
(author)
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Kendler, KS
(author)
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Kloiber, S
(author)
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Lewis, G
(author)
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Li, QQS
(author)
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Lucae, S
(author)
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Madden, PAF
(author)
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Magnusson, PKKarolinska Institutet
(author)
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Martin, NG
(author)
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Metspalu, A
(author)
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Mors, O
(author)
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Mortensen, PB
(author)
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Muller-Myhsok, B
(author)
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Nordentoft, M
(author)
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Nothen, MM
(author)
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O'Donovan, MC
(author)
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Paciga, SA
(author)
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Pedersen, NLKarolinska Institutet
(author)
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Penninx, BWJH
(author)
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Perlis, RH
(author)
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Porteous, DJ
(author)
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Potash, JB
(author)
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Preisig, M
(author)
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Rietschel, M
(author)
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Schaefer, C
(author)
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Schulze, TG
(author)
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Smoller, JW
(author)
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Stefansson, K
(author)
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Tiemeier, H
(author)
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Uher, R
(author)
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Volzke, H
(author)
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Weissman, MM
(author)
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Werge, T
(author)
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Lewis, CM
(author)
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Levinson, DF
(author)
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Breen, G
(author)
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Borglum, ASD
(author)
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Sullivan, PFKarolinska Institutet
(author)
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Karolinska Institutet
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In:Translational psychiatry: Springer Science and Business Media LLC9:1, s. 14-2158-3188
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Arnau-Soler, A
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Macdonald-Dunlop ...
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Adams, MJ
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Clarke, TK
-
MacIntyre, DJ
-
Milburn, K
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Navrady, L
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Hayward, C
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McIntosh, AM
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Thomson, PA
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Wray, NR
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Ripke, S
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Mattheisen, M
-
Trzaskowski, M
-
Byrne, EM
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Abdellaoui, A
-
Agerbo, E
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Air, TM
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Andlauer, TFM
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Bacanu, SA
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Baekvad-Hansen, ...
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Beekman, ATF
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Buttenscon, HN
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Bybjerg-Grauholm ...
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Couvy-Duchesne, ...
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Craddock, N
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Rawford, GEC
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Davies, G
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Deary, IJ
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Degenhardt, F
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Derks, EM
-
Direk, N
-
Dolan, CV
-
Dunn, EC
-
Eley, TC
-
Escott-Price, V
-
Kiadeh, FFH
-
Finucane, HK
-
Foo, JC
-
Forstner, AJ
-
Frank, J
-
Gaspar, HA
-
Gill, M
-
Goes, FS
-
Gordon, SD
-
Grove, J
-
Hall, LS
-
Hansen, CS
-
Hansen, TF
-
Herms, S
-
Hickie, IB
-
Hoffmann, P
-
Homuth, G
-
Horn, C
-
Hottenga, JJ
-
Hougaard, DM
-
Ising, M
-
Jansen, R
-
Jones, I
-
Jones, LA
-
Jorgenson, E
-
Knowles, JA
-
Kohane, IS
-
Kraft, J
-
Kretzschmar, WW
-
Krogh, J
-
Kutalik, Z
-
Li, YH
-
Lind, PA
-
Macintyre, DJ
-
MacKinnon, DF
-
Maier, RM
-
Maier, W
-
Marchini, J
-
Mbarek, H
-
McGrath, P
-
McGuffin, P
-
Medland, SE
-
Mehta, D
-
Middeldorp, CM
-
Mihailov, E
-
Milaneschi, Y
-
Milani, L
-
Mondimore, FM
-
Montgomery, GW
-
Mostafavi, S
-
Mullins, N
-
Nauck, M
-
Ng, B
-
Nivard, MG
-
Nyholt, DR
-
O'Reilly, PF
-
Oskarsson, H
-
Owen, MJ
-
Painter, JN
-
Pedersen, CB
-
Pedersen, MG
-
Peterson, RE
-
Pettersson, E
-
Peyrot, WJ
-
Pistis, G
-
Posthuma, D
-
Quiroz, JA
-
Qvist, P
-
Rice, JP
-
Riley, BP
-
Rivera, M
-
Mirza, SS
-
Schoevers, R
-
Schulte, EC
-
Shen, L
-
Shi, JX
-
Shyn, SI
-
Sigurdsson, E
-
Sinnamon, GCB
-
Smit, JH
-
Smith, DJ
-
Stefansson, H
-
Steinberg, S
-
Streit, F
-
Strohmaier, J
-
Tansey, KE
-
Teismann, H
-
Teumer, A
-
Thompson, W
-
Thorgeirsson, TE
-
Traylor, M
-
Treutlein, J
-
Trubetskoy, V
-
Uitterlinden, AG
-
Umbricht, D
-
Van der Auwera, ...
-
van Hemert, AM
-
Viktorin, A
-
Visscher, PM
-
Wang, YP
-
Webb, BT
-
Weinsheimer, SM
-
Wellmann, J
-
Willemsen, G
-
Witt, SH
-
Wu, Y
-
Xi, HLS
-
Yang, J
-
Zhang, FT
-
Arolt, V
-
Baune, BT
-
Berger, K
-
Boomsma, DI
-
Cichon, S
-
Dannlowski, U
-
de Geus, EJC
-
DePaulo, JR
-
Domenici, E
-
Domschke, K
-
Esko, T
-
Grabe, HJ
-
Hamilton, SP
-
Heath, AC
-
Kendler, KS
-
Kloiber, S
-
Lewis, G
-
Li, QQS
-
Lucae, S
-
Madden, PAF
-
Magnusson, PK
-
Martin, NG
-
Metspalu, A
-
Mors, O
-
Mortensen, PB
-
Muller-Myhsok, B
-
Nordentoft, M
-
Nothen, MM
-
O'Donovan, MC
-
Paciga, SA
-
Pedersen, NL
-
Penninx, BWJH
-
Perlis, RH
-
Porteous, DJ
-
Potash, JB
-
Preisig, M
-
Rietschel, M
-
Schaefer, C
-
Schulze, TG
-
Smoller, JW
-
Stefansson, K
-
Tiemeier, H
-
Uher, R
-
Volzke, H
-
Weissman, MM
-
Werge, T
-
Lewis, CM
-
Levinson, DF
-
Breen, G
-
Borglum, ASD
-
Sullivan, PF
-
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