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Risk of severe late...
Risk of severe late toxicity after radiotherapy following radical prostatectomy - a nationwide study
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- Braide, Karin (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology,Department of Urology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden; Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden,Univ Gothenburg, Dept Urol, Sahlgrenska Acad, Inst Clin Sci, Bruna Straket 11B, S-41345 Gothenburg, Sweden.;Sahlgrens Univ Hosp, Dept Oncol, Gothenburg, Sweden.
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- Kindblom, Jon, 1969 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology,Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden,Univ Gothenburg, Inst Clin Sci, Dept Oncol, Sahlgrenska Acad, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Dept Oncol, Gothenburg, Sweden.
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- Thellenberg-Karlsson, Camilla, 1972- (författare)
- Umeå universitet,Onkologi,Oncol Umeå Univ, Dept Radiat Sci, Umeå, Sweden.
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- Stattin, Pär (författare)
- Uppsala universitet,Urologkirurgi
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- Hugosson, Jonas, 1955 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology,Department of Urology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden; Department of Urology, Sahlgrenska University Hospital, Gothenburg, Sweden,Univ Gothenburg, Dept Urol, Sahlgrenska Acad, Inst Clin Sci, Bruna Straket 11B, S-41345 Gothenburg, Sweden.;Sahlgrens Univ Hosp, Dept Urol, Gothenburg, Sweden.
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- Månsson, Marianne, 1964 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology,Department of Urology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden,Univ Gothenburg, Dept Urol, Sahlgrenska Acad, Inst Clin Sci, Bruna Straket 11B, S-41345 Gothenburg, Sweden.
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(creator_code:org_t)
- 2022-05-21
- 2022
- Engelska.
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Ingår i: Bju International. - : Wiley. - 1464-4096 .- 1464-410X. ; 130:6, s. 799-808
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Objective To estimate the long-term risks of severe late toxicities for radiation therapy (RT) following radical prostatectomy (RP) in an unselected nationwide cohort, as severe side-effects are rare but may occur years later. Patients and Methods The study population comprised all men undergoing RP between 1997 and 2016 in the Prostate Cancer database Sweden (PCBaSe) (n = 40 962). By (1:2) matching, two cohorts were created: 2789 men exposed to postoperative RT and 5578 unexposed men with comparable age, comorbidities, and year of surgery. Cumulative incidences and rate ratios were calculated for the following outcomes: symptoms and interventions of the urinary or intestinal tract demanding inpatient care, secondary malignancies, and non-prostate cancer mortality. Results The largest differences were seen for late toxicities affecting the urinary tract. The 10-year cumulative incidences among those exposed to postoperative RT vs the RP-only group were: 17.8% vs 10.5% for procedures of the urinary tract (difference 7.3%, 95% confidence interval [CI] 4.4 to 10.3; relative risk [RR] 1.74, 95% CI 1.47 to 2.05); 6.0% vs 1.2% for haematuria (difference 4.8%, 95% CI 3.1 to 6.5; RR 6.50, 95% CI 4.31 to 10.10); and 2.4% vs 1.1% for bladder cancer (difference 1.4%, 95% CI 0.4 to 2.3; RR 2.71, 95% CI 1.72 to 4.33). The groups were similar regarding intestinal toxicity, other secondary malignancies, and non-prostate cancer mortality. Adjustments for preoperative tumour risk factors did not importantly affect the rate ratios. Conclusion Severe late toxicity after postoperative RT following RP predominately affects the bladder and can appear many years after RT.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- prostate cancer
- salvage radiation
- side-effects
- mortality
- secondary
- malignancy
- androgen-deprivation therapy
- cancer-specific mortality
- radiation-therapy
- biochemical recurrence
- adjuvant radiotherapy
- cohort
- profile
- rectal-cancer
- register
- sweden
- complications
- Urology & Nephrology
- mortality
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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