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Dissecting features...
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Allum, FMcGill Univ, Dept Human Genet, Montreal, PQ H3A 0C7, Canada;McGill Univ, Montreal, PQ H3A 0G1, Canada;Genome Quebec Innovat Ctr, Montreal, PQ H3A 0G1, Canada
(författare)
Dissecting features of epigenetic variants underlying cardiometabolic risk using full-resolution epigenome profiling in regulatory elements
- Artikel/kapitelEngelska2019
Förlag, utgivningsår, omfång ...
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2019-03-14
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Springer Science and Business Media LLC,2019
Nummerbeteckningar
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:140534158
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http://kipublications.ki.se/Default.aspx?queryparsed=id:140534158URI
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https://doi.org/10.1038/s41467-019-09184-zDOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-380447URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Sparse profiling of CpG methylation in blood by microarrays has identified epigenetic links to common diseases. Here we apply methylC-capture sequencing (MCC-Seq) in a clinical population of ~200 adipose tissue and matched blood samples (Ntotal~400), providing high-resolution methylation profiling (>1.3 M CpGs) at regulatory elements. We link methylation to cardiometabolic risk through associations to circulating plasma lipid levels and identify lipid-associated CpGs with unique localization patterns in regulatory elements. We show distinct features of tissue-specific versus tissue-independent lipid-linked regulatory regions by contrasting with parallel assessments in ~800 independent adipose tissue and blood samples from the general population. We follow-up on adipose-specific regulatory regions under (1) genetic and (2) epigenetic (environmental) regulation via integrational studies. Overall, the comprehensive sequencing of regulatory element methylomes reveals a rich landscape of functional variants linked genetically as well as epigenetically to plasma lipid traits.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Hedman, AKKarolinska Institutet,Karolinska Inst, Cardiovasc Med Unit, Dept Med Solna, S-17176 Stockholm, Sweden
(författare)
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Shaol, XJMcGill Univ, Dept Human Genet, Montreal, PQ H3A 0C7, Canada;McGill Univ, Montreal, PQ H3A 0G1, Canada;Genome Quebec Innovat Ctr, Montreal, PQ H3A 0G1, Canada
(författare)
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Cheung, WAMcGill Univ, Dept Human Genet, Montreal, PQ H3A 0C7, Canada;McGill Univ, Montreal, PQ H3A 0G1, Canada;Genome Quebec Innovat Ctr, Montreal, PQ H3A 0G1, Canada;Childrens Mercy Hosp & Clin, Kansas City, MO 64108 USA
(författare)
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Vijay, JMcGill Univ, Dept Human Genet, Montreal, PQ H3A 0C7, Canada;McGill Univ, Montreal, PQ H3A 0G1, Canada;Genome Quebec Innovat Ctr, Montreal, PQ H3A 0G1, Canada
(författare)
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Guenard, FUniv Laval, Inst Nutr & Funct Foods INAF, Quebec City, PQ G1V 0A6, Canada
(författare)
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Kwan, TMcGill Univ, Dept Human Genet, Montreal, PQ H3A 0C7, Canada;McGill Univ, Montreal, PQ H3A 0G1, Canada;Genome Quebec Innovat Ctr, Montreal, PQ H3A 0G1, Canada
(författare)
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Simon, MMMcGill Univ, Dept Human Genet, Montreal, PQ H3A 0C7, Canada;McGill Univ, Montreal, PQ H3A 0G1, Canada;Genome Quebec Innovat Ctr, Montreal, PQ H3A 0G1, Canada
(författare)
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Ge, BMcGill Univ, Dept Human Genet, Montreal, PQ H3A 0C7, Canada;McGill Univ, Montreal, PQ H3A 0G1, Canada;Genome Quebec Innovat Ctr, Montreal, PQ H3A 0G1, Canada
(författare)
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Moura, CMcGill Univ, Dept Epidemiol, Montreal, PQ H3A 1A2, Canada
(författare)
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Boulier, EMcGill Univ, Dept Human Genet, Montreal, PQ H3A 0C7, Canada;McGill Univ, Montreal, PQ H3A 0G1, Canada;Genome Quebec Innovat Ctr, Montreal, PQ H3A 0G1, Canada
(författare)
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Rönnblom, LarsUppsala universitet,Reumatologi(Swepub:uu)larsronn
(författare)
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Bernatsky, SMcGill Univ, Dept Epidemiol, Montreal, PQ H3A 1A2, Canada
(författare)
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Lathropl, MMcGill Univ, Dept Human Genet, Montreal, PQ H3A 0C7, Canada;McGill Univ, Montreal, PQ H3A 0G1, Canada;Genome Quebec Innovat Ctr, Montreal, PQ H3A 0G1, Canada
(författare)
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McCarthy, MIUniv Oxford, Churchill Hosp, Oxford Ctr Diabet Endocrinol & Metab, Old Rd, Oxford OX3 7LJ, England;Univ Oxford, Wellcome Ctr Human Genet, Roosevelt Dr, Oxford OX3 7BN, England;Oxford Univ Hosp NHS Fdn Trust, John Radcliffe Hosp, Oxford NIHR Biomed Res Ctr, Oxford OX3 9DU, England
(författare)
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Deloukas, PQueen Mary Univ London, William Harvey Res Inst, Barts & London Sch Med & Dent, Charterhouse Sq, London EC1M 6BQ, England
(författare)
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Tchernof, AUniv Laval, Quebec Heart & Lung Inst, Quebec City, PQ G1V 0A6, Canada
(författare)
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Pastinen, TMcGill Univ, Dept Human Genet, Montreal, PQ H3A 0C7, Canada;McGill Univ, Montreal, PQ H3A 0G1, Canada;Genome Quebec Innovat Ctr, Montreal, PQ H3A 0G1, Canada;Childrens Mercy Hosp & Clin, Kansas City, MO 64108 USA
(författare)
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Vohl, MCUniv Laval, Inst Nutr & Funct Foods INAF, Quebec City, PQ G1V 0A6, Canada
(författare)
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Grundberg, EMcGill Univ, Dept Human Genet, Montreal, PQ H3A 0C7, Canada;McGill Univ, Montreal, PQ H3A 0G1, Canada;Genome Quebec Innovat Ctr, Montreal, PQ H3A 0G1, Canada;Childrens Mercy Hosp & Clin, Kansas City, MO 64108 USA
(författare)
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Karolinska InstitutetMcGill Univ, Dept Human Genet, Montreal, PQ H3A 0C7, Canada;McGill Univ, Montreal, PQ H3A 0G1, Canada;Genome Quebec Innovat Ctr, Montreal, PQ H3A 0G1, Canada
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Nature communications: Springer Science and Business Media LLC10:1, s. 1209-2041-1723
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Till lärosätets databas
- Av författaren/redakt...
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Allum, F
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Hedman, AK
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Shaol, XJ
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Cheung, WA
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Vijay, J
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Guenard, F
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visa fler...
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Kwan, T
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Simon, MM
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Ge, B
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Moura, C
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Boulier, E
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Rönnblom, Lars
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Bernatsky, S
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Lathropl, M
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McCarthy, MI
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Deloukas, P
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Tchernof, A
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Pastinen, T
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Vohl, MC
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Grundberg, E
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visa färre...
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Karolinska Institutet
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