Search: onr:"swepub:oai:prod.swepub.kib.ki.se:140947883" >
The Prognostic Role...
The Prognostic Roles of Pretreatment Circulating Tumor Cells, Circulating Cancer Stem-Like Cells, and Programmed Cell Death-1 Expression on Peripheral Lymphocytes in Patients with Initially Unresectable, Recurrent or Metastatic Head and Neck Cancer: An Exploratory Study of Three Biomarkers in One-time Blood Drawing
- Article/chapterEnglish2019
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:prod.swepub.kib.ki.se:140947883
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:140947883URI
-
https://doi.org/10.3390/cancers11040540DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Circulating tumor cells (CTCs) and immune status are strongly related to cancer prognosis, although few studies have examined both factors. This prospective observational study (ClinicalTrials.gov: NCT02420600) evaluated whether CTCs, circulating cancer stem-like cells (cCSCs), and peripheral lymphocytes with/without Programmed cell death protein 1 (PD-1) expression were associated with prognosis among patients receiving palliative chemotherapy for initially unresectable, recurrent/metastatic head and neck squamous cell carcinoma (rmHNSCC). Thirty-four patients were enrolled between January 2015 and June 2016. Overall survival (OS) was associated with a higher CTC number (hazard ratio [HR]: 1.01, p = 0.0004) and cCSC ratio (HR: 29.903, p < 0.0001). Progression-free survival (PFS) was also associated with CTC number (HR: 1.013, p = 0.002) and cCSC ratio (HR: 10.92, p = 0.003). A CD8+ proportion of ≥ 17% was associated with improved OS (HR: 0.242, p = 0.004). A CD4: CD8 ratio of >1.2 was associated with poorer trend of PFS (HR: 2.12, p = 0.064). PD-1 expression was not associated with survival outcomes. Baseline CTCs, cCSC ratio, and CD8+ ratio may predict prognosis in rmHNSCC.
Added entries (persons, corporate bodies, meetings, titles ...)
-
Wu, MH
(author)
-
Liu, SY
(author)
-
Wang, HM
(author)
-
Huang, WKKarolinska Institutet
(author)
-
Liao, CT
(author)
-
Yen, TC
(author)
-
Ng, SH
(author)
-
Chen, JS
(author)
-
Lin, YC
(author)
-
Lin, HC
(author)
-
Hsieh, JCH
(author)
-
Karolinska Institutet
(creator_code:org_t)
Related titles
-
In:Cancers: MDPI AG11:42072-6694
Internet link
Find in a library
-
Cancers
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Chang, PH
-
Wu, MH
-
Liu, SY
-
Wang, HM
-
Huang, WK
-
Liao, CT
-
show more...
-
Yen, TC
-
Ng, SH
-
Chen, JS
-
Lin, YC
-
Lin, HC
-
Hsieh, JCH
-
show less...
- Articles in the publication
-
Cancers
- By the university
-
Karolinska Institutet