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Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns
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Czamara, D (author)
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Eraslan, G (author)
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Page, CM (author)
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show more...
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Lahti, J (author)
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Lahti-Pulkkinen, M (author)
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Hamalainen, E (author)
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Kajantie, E (author)
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Laivuori, H (author)
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Villa, PM (author)
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Reynolds, RM (author)
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Nystad, W (author)
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Haberg, SE (author)
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London, SJ (author)
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O'Donnell, KJ (author)
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Garg, E (author)
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Meaney, MJ (author)
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Entringer, S (author)
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Wadhwa, PD (author)
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Buss, C (author)
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Jones, MJ (author)
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Lin, DTS (author)
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MacIsaac, JL (author)
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Kobor, MS (author)
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Koen, N (author)
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Zar, HJ (author)
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Koenen, KC (author)
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Dalvie, S (author)
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Stein, DJ (author)
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Kondofersky, I (author)
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Muller, NS (author)
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Theis, FJ (author)
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Raikkonen, K (author)
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Binder, EB (author)
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Wray, NR (author)
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Ripke, S (author)
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Mattheisen, M (author)
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Trzaskowski, M (author)
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Byrne, EM (author)
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Abdellaoui, A (author)
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Adams, MJ (author)
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Agerbo, E (author)
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Air, TM (author)
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Andlauer, TFM (author)
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Bacanu, SA (author)
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Baekvad-Hansen, M (author)
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Beekman, ATF (author)
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Bigdeli, TB (author)
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Blackwood, DHR (author)
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- Bryois, J (author)
- Karolinska Institutet
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Buttenschon, HN (author)
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Bybjerg-Grauholm, J (author)
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Cai, N (author)
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Castelao, E (author)
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Christensen, JH (author)
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Clarke, TK (author)
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Coleman, JR (author)
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Colodro-Conde, L (author)
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Couvy-Duchesne, B (author)
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Craddock, N (author)
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Crawford, GE (author)
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Davies, G (author)
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Deary, IJ (author)
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Degenhardt, F (author)
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Derks, EM (author)
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Direk, N (author)
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Dolan, C (author)
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Dunn, EC (author)
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Eley, TC (author)
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Escott-Price, V (author)
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Kiadeh, FFH (author)
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Finucane, HK (author)
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Forstner, AJ (author)
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Frank, J (author)
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Gaspar, HA (author)
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Gill, M (author)
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Goes, FS (author)
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Gordon, SD (author)
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Grove, J (author)
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Hall, LS (author)
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Hansen, CS (author)
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Hansen, TF (author)
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Herms, S (author)
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Hickie, IB (author)
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Hoffmann, P (author)
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Homuth, G (author)
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Horn, C (author)
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Hottenga, JJ (author)
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Hougaard, DM (author)
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Ising, M (author)
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Jansen, R (author)
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Jorgenson, E (author)
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Knowles, JA (author)
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Kohane, IS (author)
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Kraft, J (author)
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Kretzschmar, WW (author)
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Krogh, J (author)
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Kutalik, Z (author)
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Li, YH (author)
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Lind, PA (author)
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MacIntyre, DJ (author)
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MacKinnon, DF (author)
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Maier, RM (author)
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Maier, W (author)
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Marchini, J (author)
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Mbarek, H (author)
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McGrath, P (author)
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McGuffin, P (author)
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Medland, SE (author)
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Mehta, D (author)
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Middeldorp, CM (author)
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Mihailov, E (author)
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Milaneschi, Y (author)
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Milani, L (author)
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Mondimore, FM (author)
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Montgomery, GW (author)
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Mostafavi, S (author)
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Mullins, N (author)
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Nauck, M (author)
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Ng, B (author)
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Nivard, MG (author)
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Nyholt, DR (author)
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O'Reilly, PF (author)
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Oskarsson, H (author)
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Owen, MJ (author)
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Painter, JN (author)
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Pedersen, CB (author)
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Pedersen, MG (author)
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Peterson, RE (author)
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Pettersson, E (author)
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Peyrot, WJ (author)
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Pistis, G (author)
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Posthuma, D (author)
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Quiroz, JA (author)
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Qvist, P (author)
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Rice, JP (author)
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Riley, BP (author)
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Rivera, M (author)
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Mirza, SS (author)
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Schoevers, R (author)
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Schulte, EC (author)
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Shen, L (author)
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Shi, JX (author)
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Shyn, S (author)
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Sigurdsson, E (author)
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Sinnamon, GCB (author)
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Smit, JH (author)
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Smith, DJ (author)
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Stefansson, H (author)
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Steinberg, S (author)
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Streit, F (author)
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Strohmaier, J (author)
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Tansey, KE (author)
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Teismann, H (author)
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Teumer, A (author)
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Thompson, W (author)
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Thomson, PA (author)
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Thorgeirsson, TE (author)
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Traylor, M (author)
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Treutlein, J (author)
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Trubetskoy, V (author)
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Uitterlinden, AG (author)
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Umbricht, D (author)
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Van der Auwera, S (author)
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van Hemert, AM (author)
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- Viktorin, A (author)
- Karolinska Institutet
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Visscher, PM (author)
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Wang, YP (author)
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Webb, BT (author)
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Weinsheimer, SM (author)
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Wellmann, J (author)
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Willemsen, G (author)
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Witt, SH (author)
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Wu, Y (author)
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Xi, HLS (author)
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Yang, J (author)
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Zhang, FT (author)
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Arolt, V (author)
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Baune, BT (author)
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Berger, K (author)
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Boomsma, D (author)
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Cichon, S (author)
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Dannlowski, U (author)
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de Geus, EJC (author)
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DePaulo, JR (author)
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Domenici, E (author)
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Domschke, K (author)
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Esko, T (author)
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Grabe, HJ (author)
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Hamilton, SP (author)
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Hayward, C (author)
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Heath, AC (author)
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Kendler, KS (author)
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Kloiber, S (author)
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Lewis, G (author)
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Li, QQS (author)
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Lucae, S (author)
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Madden, PAF (author)
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- Magnusson, PK (author)
- Karolinska Institutet
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Martin, NG (author)
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McIntosh, AM (author)
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Metspalu, A (author)
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Mors, O (author)
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Mortensen, PB (author)
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Muller-Myhsok, B (author)
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Nordentoft, M (author)
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Nothen, MM (author)
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O'Donovan, MC (author)
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Paciga, SA (author)
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- Pedersen, NL (author)
- Karolinska Institutet
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Penninx, BWJH (author)
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Perlis, RH (author)
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Porteous, DJ (author)
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Potash, JB (author)
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Preisig, M (author)
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Rietschel, M (author)
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Schaefer, C (author)
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Schulze, TG (author)
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Smoller, JW (author)
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Stefansson, K (author)
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Tiemeier, H (author)
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Uher, R (author)
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Volzke, H (author)
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Weissman, MM (author)
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Werge, T (author)
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Lewis, CM (author)
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Levinson, DF (author)
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Breen, G (author)
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Borglum, AD (author)
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Sullivan, PF (author)
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(creator_code:org_t)
- 2019-06-11
- 2019
- English.
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In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 2548-
- Related links:
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https://www.nature.c...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Epigenetic processes, including DNA methylation (DNAm), are among the mechanisms allowing integration of genetic and environmental factors to shape cellular function. While many studies have investigated either environmental or genetic contributions to DNAm, few have assessed their integrated effects. Here we examine the relative contributions of prenatal environmental factors and genotype on DNA methylation in neonatal blood at variably methylated regions (VMRs) in 4 independent cohorts (overall n = 2365). We use Akaike’s information criterion to test which factors best explain variability of methylation in the cohort-specific VMRs: several prenatal environmental factors (E), genotypes in cis (G), or their additive (G + E) or interaction (GxE) effects. Genetic and environmental factors in combination best explain DNAm at the majority of VMRs. The CpGs best explained by either G, G + E or GxE are functionally distinct. The enrichment of genetic variants from GxE models in GWAS for complex disorders supports their importance for disease risk.
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- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Czamara, D
-
Eraslan, G
-
Page, CM
-
Lahti, J
-
Lahti-Pulkkinen, ...
-
Hamalainen, E
-
show more...
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Kajantie, E
-
Laivuori, H
-
Villa, PM
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Reynolds, RM
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Nystad, W
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Haberg, SE
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London, SJ
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O'Donnell, KJ
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Garg, E
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Meaney, MJ
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Entringer, S
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Wadhwa, PD
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Buss, C
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Jones, MJ
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Lin, DTS
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MacIsaac, JL
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Kobor, MS
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Koen, N
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Zar, HJ
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Koenen, KC
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Dalvie, S
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Stein, DJ
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Kondofersky, I
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Muller, NS
-
Theis, FJ
-
Raikkonen, K
-
Binder, EB
-
Wray, NR
-
Ripke, S
-
Mattheisen, M
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Trzaskowski, M
-
Byrne, EM
-
Abdellaoui, A
-
Adams, MJ
-
Agerbo, E
-
Air, TM
-
Andlauer, TFM
-
Bacanu, SA
-
Baekvad-Hansen, ...
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Beekman, ATF
-
Bigdeli, TB
-
Blackwood, DHR
-
Bryois, J
-
Buttenschon, HN
-
Bybjerg-Grauholm ...
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Cai, N
-
Castelao, E
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Christensen, JH
-
Clarke, TK
-
Coleman, JR
-
Colodro-Conde, L
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Couvy-Duchesne, ...
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Craddock, N
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Crawford, GE
-
Davies, G
-
Deary, IJ
-
Degenhardt, F
-
Derks, EM
-
Direk, N
-
Dolan, C
-
Dunn, EC
-
Eley, TC
-
Escott-Price, V
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Kiadeh, FFH
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Finucane, HK
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Forstner, AJ
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Frank, J
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Gaspar, HA
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Gill, M
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Goes, FS
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Gordon, SD
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Grove, J
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Hall, LS
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Hansen, CS
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Hansen, TF
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Herms, S
-
Hickie, IB
-
Hoffmann, P
-
Homuth, G
-
Horn, C
-
Hottenga, JJ
-
Hougaard, DM
-
Ising, M
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Jansen, R
-
Jorgenson, E
-
Knowles, JA
-
Kohane, IS
-
Kraft, J
-
Kretzschmar, WW
-
Krogh, J
-
Kutalik, Z
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Li, YH
-
Lind, PA
-
MacIntyre, DJ
-
MacKinnon, DF
-
Maier, RM
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Maier, W
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Marchini, J
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Mbarek, H
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McGrath, P
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McGuffin, P
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Medland, SE
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Mehta, D
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Middeldorp, CM
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Mihailov, E
-
Milaneschi, Y
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Milani, L
-
Mondimore, FM
-
Montgomery, GW
-
Mostafavi, S
-
Mullins, N
-
Nauck, M
-
Ng, B
-
Nivard, MG
-
Nyholt, DR
-
O'Reilly, PF
-
Oskarsson, H
-
Owen, MJ
-
Painter, JN
-
Pedersen, CB
-
Pedersen, MG
-
Peterson, RE
-
Pettersson, E
-
Peyrot, WJ
-
Pistis, G
-
Posthuma, D
-
Quiroz, JA
-
Qvist, P
-
Rice, JP
-
Riley, BP
-
Rivera, M
-
Mirza, SS
-
Schoevers, R
-
Schulte, EC
-
Shen, L
-
Shi, JX
-
Shyn, S
-
Sigurdsson, E
-
Sinnamon, GCB
-
Smit, JH
-
Smith, DJ
-
Stefansson, H
-
Steinberg, S
-
Streit, F
-
Strohmaier, J
-
Tansey, KE
-
Teismann, H
-
Teumer, A
-
Thompson, W
-
Thomson, PA
-
Thorgeirsson, TE
-
Traylor, M
-
Treutlein, J
-
Trubetskoy, V
-
Uitterlinden, AG
-
Umbricht, D
-
Van der Auwera, ...
-
van Hemert, AM
-
Viktorin, A
-
Visscher, PM
-
Wang, YP
-
Webb, BT
-
Weinsheimer, SM
-
Wellmann, J
-
Willemsen, G
-
Witt, SH
-
Wu, Y
-
Xi, HLS
-
Yang, J
-
Zhang, FT
-
Arolt, V
-
Baune, BT
-
Berger, K
-
Boomsma, D
-
Cichon, S
-
Dannlowski, U
-
de Geus, EJC
-
DePaulo, JR
-
Domenici, E
-
Domschke, K
-
Esko, T
-
Grabe, HJ
-
Hamilton, SP
-
Hayward, C
-
Heath, AC
-
Kendler, KS
-
Kloiber, S
-
Lewis, G
-
Li, QQS
-
Lucae, S
-
Madden, PAF
-
Magnusson, PK
-
Martin, NG
-
McIntosh, AM
-
Metspalu, A
-
Mors, O
-
Mortensen, PB
-
Muller-Myhsok, B
-
Nordentoft, M
-
Nothen, MM
-
O'Donovan, MC
-
Paciga, SA
-
Pedersen, NL
-
Penninx, BWJH
-
Perlis, RH
-
Porteous, DJ
-
Potash, JB
-
Preisig, M
-
Rietschel, M
-
Schaefer, C
-
Schulze, TG
-
Smoller, JW
-
Stefansson, K
-
Tiemeier, H
-
Uher, R
-
Volzke, H
-
Weissman, MM
-
Werge, T
-
Lewis, CM
-
Levinson, DF
-
Breen, G
-
Borglum, AD
-
Sullivan, PF
-
show less...
- Articles in the publication
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Nature communica ...
- By the university
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Karolinska Institutet