Natural disease course of Crohn's disease during the first 5 years after diagnosis in a European population-based inception cohort: an Epi-IBD study

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Natural disease course of Crohn's disease during the first 5 years after diagnosis in a European population-based inception cohort: an Epi-IBD study

Burisch, J (author): Department of Gastroenterology, Nordsjællands Hospital, University of Copenhagen, Frederikssund, Denmark

Kiudelis, G (author): Institute for Digestive Research, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania

Kupcinskas, L (author): Institute for Digestive Research, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania; Department of Gastroenterology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania

Kievit, HAL (author): Department of Medicine, Herning Central Hospital, Herning, Denmark

Andersen, KW (author): Medical Department, Regional Hospital of Viborg, Viborg, Denmark

Andersen, V (author): Medical Department, Regional Hospital of Viborg, Viborg, Denmark; Focused research unit for Molecular Diagnostic and Clinical Research (MOK), IRS-Center Sonderjylland, Hospital of Southern Jutland, Aabenraa, Denmark

Salupere, R (author): Division of Gastroenterology, Tartu University Hospital, University of Tartyu, Tartu, Estonia

Pedersen, N (author): Gastroenterology Department, Slagelse Hospital, Slagelse, Denmark

Kjeldsen, J (author): Gastroenterology Department, Odense University Hospital, Odense, Denmark

D'Inca, R (author): Department of Surgical, Oncological and Gastroenterological Sciences, Azienda, University of Padua, Padova, Italy,IBD Clinical and Research Centre (ISCARE), Prague, Czech Republic

Valpiani, D (author): U.O. Gastroenterologia ed Endoscopia digestiva, Hospital Morgagni Pierantoni, Forlì, Italy

Schwartz, D (author): Department of Gastroenterology and Hepatology, Soroka Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel

Odes, S (author): Department of Gastroenterology and Hepatology, Soroka Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel

Olsen, J (author): Medical Department, The National Hospital of the Faroe Islands, Thorshavn, Denmark

Nielsen, KR (author): Medical Department, The National Hospital of the Faroe Islands, Thorshavn, Denmark

Vegh, Z (author): 1st Department of Medicine, Semmelweis University, Budapest, Hungary

Lakatos, PL (author): 1st Department of Medicine, Semmelweis University, Budapest, Hungary; Division of Gastroenterology, McGill University Health Center, Montreal, Canada

Toca, A (author): Department of Gastroenterology, State University of Medicine and Pharmacy of the Republic of Moldova, Chisinau, Republic of Moldova

Turcan, S (author): Department of Gastroenterology, State University of Medicine and Pharmacy of the Republic of Moldova, Chisinau, Republic of Moldova

Katsanos, KH (author): Department of Gastroenterology, University Hospital of Ioannina, Ioannina, Greece

Christodoulou, DK (author): Department of Gastroenterology, University Hospital of Ioannina, Ioannina, Greece

Fumery, M (author): Gastroenterology Unit, Epimad Registry, Centre hospitalier universitaire (CHU) Amiens Sud, Amiens University Hospital, Amiens, France

Gower-Rousseau, C (author): Public Health, Epidemiology and Economic Health, Registre Epimad, Lille Hospital, Lille University, Lille, France; Lille Inflammation Research International Center (LIRIC), Lille University, Lille, France

Zammit, SC (author): Division of Gastroenterology, Mater Dei Hospital, Msida, Malta,IBD Unit, Hull and East Yorkshire NHS Trust, Hull, UK

Ellul, P (author): Division of Gastroenterology, Mater Dei Hospital, Msida, Malta

Eriksson, Carl, 1981- (author): Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden

Halfvarson, Jonas, 1970- (author): Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden

Magro, FJ (author): Department of Gastroenterology, Centro Hospitalar de São João EPE, Porto, Portugal; Department of Biomedicine, Institute of Pharmacology, Faculty of Medicine, Porto University, Porto, Portugal

Duricova, D (author)

Bortlik, M (author): IBD Clinical and Research Centre (ISCARE), Prague, Czech Republic; Institute of Pharmacology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic

Fernandez, A (author): Department of Gastroenterology, Hospital POVISA, Vigo, Spain

Hernandez, V (author): Department of Gastroenterology, Hospital Alvaro Cunqueiro. Instituto Investigación Sanitaria Galicia Sur. EOXI de Vigo, Vigo, Spain

Myers, S (author): IBD Unit, Hull and East Yorkshire NHS Trust, Hull, UK

Sebastian, S (author)

Oksanen, P (author): Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland; University of Tampere, Tampere, Finland

Collin, P (author): University of Tampere, Tampere, Finland

Goldis, A (author): Clinic of Gastroenterology, University of Medicine 'Victor Babes', Timisoara, Romania

Misra, R (author): IBD Department, Imperial College London, London, UK

Arebi, N (author): IBD Department, Imperial College London, London, UK

Kaimakliotis, IP (author): Nicosia private practice, Nicosia, Cyprus

Nikuina, I (author): Department of Gastroenterology, Moscow Regional Research Clinical Institute, Moscow, Russian Federation

Belousova, E (author): Department of Gastroenterology, Moscow Regional Research Clinical Institute, Moscow, Russian Federation

Brinar, M (author): Division of Gastroenterology and Hepatology, University Hospital Center Zagreb, Zagreb, Croatia

Cukovic-Cavka, S (author): Division of Gastroenterology and Hepatology, University Hospital Center Zagreb, Zagreb, Croatia

Langholz, E (author): Department of Gastroenterology, Herlev and Gentofte Hospital, University of Copenhagen, Herlev, Denmark

Munkholm, P (author): Department of Gastroenterology, Nordsjællands Hospital, University of Copenhagen, Frederikssund, Denmark

Niewiadomski, O (author)

Bell, S (author)

Turk, N (author)

Cukovic-Cavka, S (author)

Kaimakliotis, I (author)

Nicolaou, A (author)

Duricova, D (author)

Lukas, M (author)

Bortlik, M (author)

Shonova, O (author)

Burisch, J (author)

Munkholm, P (author)

Langholz, E (author)

Blichfeldt, B (author)

Marker, D (author)

Carlsen, K (author)

Weimers, P (author)

Pedersen, N (author)

Kjeldsen, J (author)

Aalykke, C (author)

Dahlerup, JF (author)

Kudsk, K (author)

Andersen, V (author)

Vind, I (author)

Thorsgaard, N (author)

Salupere, R (author)

Olsen, J (author)

Nielsen, KR (author)

Oksanen, P (author)

Collin, P (author)

Katsanos, KH (author)

Christodoulou, DK (author)

Skamnelos, A (author)

Politis, D (author)

Ladefoged, K (author)

Lakatos, PL (author)

Vegh, Z (author)

Lakatos, L (author)

Demenyi, P (author)

Kramli, SN (author)

O'Morain, C (author)

Dal Piaz, G (author)

Santini, A (author)

Girardin, G (author)

D'Inca, R (author)

Schwartz, D (author)

Odes, S (author)

Kupcinskas, L (author)

Jonaitis, L (author)

Kiudelis, G (author)

Valantiene, I (author)

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(creator_code:org_t)

2018-01-23
2019
English.
In: Gut. - : BMJ. - 1468-3288 .- 0017-5749. ; 68:3, s. 423-433

Related links:: http://kipublication...; show more...; https://doi.org/10.1...; https://urn.kb.se/re...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

The Epi-IBD cohort is a prospective population-based inception cohort of unselected patients with inflammatory bowel disease from 29 European centres covering a background population of almost 10 million people. The aim of this study was to assess the 5-year outcome and disease course of patients with Crohn’s disease (CD).DesignPatients were followed up prospectively from the time of diagnosis, including collection of their clinical data, demographics, disease activity, medical therapy, surgery, cancers and deaths. Associations between outcomes and multiple covariates were analysed by Cox regression analysis.ResultsIn total, 488 patients were included in the study. During follow-up, 107 (22%) patients received surgery, while 176 (36%) patients were hospitalised because of CD. A total of 49 (14%) patients diagnosed with non-stricturing, non-penetrating disease progressed to either stricturing and/or penetrating disease. These rates did not differ between patients from Western and Eastern Europe. However, significant geographic differences were noted regarding treatment: more patients in Western Europe received biological therapy (33%) and immunomodulators (66%) than did those in Eastern Europe (14% and 54%, respectively, P<0.01), while more Eastern European patients received 5-aminosalicylates (90% vs 56%, P<0.05). Treatment with immunomodulators reduced the risk of surgery (HR: 0.4, 95% CI 0.2 to 0.6) and hospitalisation (HR: 0.3, 95% CI 0.2 to 0.5).ConclusionDespite patients being treated early and frequently with immunomodulators and biological therapy in Western Europe, 5-year outcomes including surgery and phenotype progression in this cohort were comparable across Western and Eastern Europe. Differences in treatment strategies between Western and Eastern European centres did not affect the disease course. Treatment with immunomodulators reduced the risk of surgery and hospitalisation.

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By the author/editor: Burisch, J; Kiudelis, G; Kupcinskas, L; Kievit, HAL; Andersen, KW; Andersen, V; show more...; Salupere, R; Pedersen, N; Kjeldsen, J; D'Inca, R; Valpiani, D; Schwartz, D; Odes, S; Olsen, J; Nielsen, KR; Vegh, Z; Lakatos, PL; Toca, A; Turcan, S; Katsanos, KH; Christodoulou, D ...; Fumery, M; Gower-Rousseau, ...; Zammit, SC; Ellul, P; Eriksson, Carl, ...; Halfvarson, Jona ...; Magro, FJ; Duricova, D; Bortlik, M; Fernandez, A; Hernandez, V; Myers, S; Sebastian, S; Oksanen, P; Collin, P; Goldis, A; Misra, R; Arebi, N; Kaimakliotis, IP; Nikuina, I; Belousova, E; Brinar, M; Cukovic-Cavka, S; Langholz, E; Munkholm, P; Niewiadomski, O; Bell, S; Turk, N; Kaimakliotis, I; Nicolaou, A; Lukas, M; Shonova, O; Blichfeldt, B; Marker, D; Carlsen, K; Weimers, P; Aalykke, C; Dahlerup, JF; Kudsk, K; Vind, I; Thorsgaard, N; Skamnelos, A; Politis, D; Ladefoged, K; Lakatos, L; Demenyi, P; Kramli, SN; O'Morain, C; Dal Piaz, G; Santini, A; Girardin, G; Jonaitis, L; Valantiene, I; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Gastroenterology ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Public Health Gl ...

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By the university: Karolinska Institutet; Örebro University

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Natural disease course of Crohn's disease during the first 5 years after diagnosis in a European population-based inception cohort: an Epi-IBD study

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