Acupuncture or metformin to improve insulin resistance in women with polycystic ovary syndrome: study protocol of a combined multinational cross sectional case-control study and a randomised controlled trial

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: WFRF:(Li ZJ) > Acupuncture or metf...

Stener-Victorin, EKarolinska Institutet (författare)

Acupuncture or metformin to improve insulin resistance in women with polycystic ovary syndrome: study protocol of a combined multinational cross sectional case-control study and a randomised controlled trial

Artikel/kapitelEngelska2019

Förlag, utgivningsår, omfång ...

2019-01-04
BMJ,2019

Nummerbeteckningar

LIBRIS-ID:oai:prod.swepub.kib.ki.se:141238482
http://kipublications.ki.se/Default.aspx?queryparsed=id:141238482URI
https://doi.org/10.1136/bmjopen-2018-024733DOI

Kompletterande språkuppgifter

Språk:engelska
Sammanfattning på:engelska

Ingår i deldatabas

SwePubSwePub

Klassifikation

Ämneskategori:ref swepub-contenttype
Ämneskategori:art swepub-publicationtype

Anmärkningar

Polycystic ovary syndrome (PCOS) is linked to hyperinsulinemia and insulin resistance with dysfunctional glucose metabolism. Pilot studies suggests that acupuncture treatment with combined manual and low-frequency electrical stimulation (electroacupuncture (EA)) of the needles decrease circulating glycated haemoglobulin (HbA1c) and homeostatic model assessment-insulin resistance. Therefore, we here aim to investigate if acupuncture treatment or metformin together with lifestyle or lifestyle management alone improves insulin sensitivity and related symptoms in overweight/obese women with PCOS.Methods and analysisThis is a two-centre multinational (Sweden and China), cross-sectional case–control study combined with an open-labelled randomised controlled trial (RCT). Participants are randomised to one of three groups: (1) EA 2–3 times/week during 4 months+lifestyle management; (2) metformin, 500 mg, three/day during 4 months+lifestyle management; or (3) lifestyle management alone. The primary outcome measure in the RCT is changes in HbA1C. A total of 123 obese overweight women with PCOS will be enrolled and randomised into one of the three groups with a target power of at least 80% and 5% significance level based on two-sided tests.Ethics and disseminationThe study has been approved by the Regional Ethical Review Board of Stockholm and of Peking University Third Hospital, China. Primary outcome data of the RCT will be published in a relevant journal together with supporting secondary outcome measurements. Further, outcome measurements will be published in separate papers as well as case–control data.Expected resultsWe anticipate that EA and metformin, both with lifestyle management, are equally effective and superior to lifestyle management alone for improvement of glycaemic control.Trial registration numbersNCT02647827and EudraCT2015-004250-18.

Biuppslag (personer, institutioner, konferenser, titlar ...)

Zhang, HL (författare)
Li, R (författare)
Friden, CKarolinska Institutet (författare)
Li, D (författare)
Wang, W (författare)
Wang, HN (författare)
Chang, CQ (författare)
Li, S (författare)
Huo, ZJ (författare)
Zhang, H (författare)
Ji, XL (författare)
Linden-Hirschberg, A (författare)
Qiao, J (författare)
Karolinska Institutet (creator_code:org_t)

Sammanhörande titlar

Ingår i:BMJ open: BMJ9:1, s. e024733-2044-6055

Internetlänk

Hitta via bibliotek

BMJ open (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: Stener-Victorin, ...; Zhang, HL; Li, R; Friden, C; Li, D; Wang, W; visa fler...; Wang, HN; Chang, CQ; Li, S; Huo, ZJ; Zhang, H; Ji, XL; Linden-Hirschber ...; Qiao, J; visa färre...

Artiklar i publikationen: BMJ open

Av lärosätet: Karolinska Institutet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se