Search: id:"swepub:oai:prod.swepub.kib.ki.se:141413143" >
Genetic Analysis of...
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Sirotkina, MKarolinska Institutet
(author)
Genetic Analysis of Copy Number Variation in Large Chorangiomas
- Article/chapterEnglish2019
Publisher, publication year, extent ...
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2018-11-14
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SAGE Publications,2019
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:141413143
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http://kipublications.ki.se/Default.aspx?queryparsed=id:141413143URI
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https://doi.org/10.1177/1093526618811744DOI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Chorangioma (CA) is the most common nontrophoblastic, vascular tumor-like lesion of the placenta with a reported incidence of 0.5% to 1% in all examined placentas. The underlying molecular mechanisms of CAs are still poorly elucidated, and a systematic investigation of the genetic background of CAs has not previously been done. Materials and Methods Tissue biopsies from 8 large (>40 mm) histologically confirmed CAs and 8 unaffected matched placenta controls, along with standard control DNA samples were analyzed for large genomic deletions and duplications using array comparative genomic hybridization (array-CGH) method. Results Array-CGH analysis revealed no rare or novel copy number variants in the CA samples compared with either standard control DNA or unaffected placenta DNA from the same individual. Discussion In this study, a systematic genetic investigation of 8 large CAs failed to demonstrate any large-scale pathogenic genetic changes. This lack of association might support a nongenetic, nontumorous origin of these lesions; however, additional genetic studies focusing on smaller genomic alterations are required to fully assess any possible genetic contribution.
Added entries (persons, corporate bodies, meetings, titles ...)
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Douroudis, K
(author)
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Westgren, MKarolinska Institutet
(author)
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Papadogiannakis, NKarolinska Institutet
(author)
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Karolinska Institutet
(creator_code:org_t)
Related titles
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In:Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society: SAGE Publications22:3, s. 236-2421615-5742
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In:Pediatric and Developmental Pathology: SAGE Publications22:3, s. 236-2421093-5266
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