Genetic Analysis of Copy Number Variation in Large Chorangiomas

Chorangioma (CA) is the most common nontrophoblastic, vascular tumor-like lesion of the placenta with a reported incidence of 0.5% to 1% in all examined placentas. The underlying molecular mechanisms of CAs are still poorly elucidated, and a systematic investigation of the genetic background of CAs has not previously been done. Materials and Methods Tissue biopsies from 8 large (>40 mm) histologically confirmed CAs and 8 unaffected matched placenta controls, along with standard control DNA samples were analyzed for large genomic deletions and duplications using array comparative genomic hybridization (array-CGH) method. Results Array-CGH analysis revealed no rare or novel copy number variants in the CA samples compared with either standard control DNA or unaffected placenta DNA from the same individual. Discussion In this study, a systematic genetic investigation of 8 large CAs failed to demonstrate any large-scale pathogenic genetic changes. This lack of association might support a nongenetic, nontumorous origin of these lesions; however, additional genetic studies focusing on smaller genomic alterations are required to fully assess any possible genetic contribution.

In:Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society: SAGE Publications22:3, s. 236-2421615-5742
In:Pediatric and Developmental Pathology: SAGE Publications22:3, s. 236-2421093-5266

By the author/editor: Sirotkina, M; Douroudis, K; Westgren, M; Papadogiannakis, ...

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