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Retrotransposon ins...
Retrotransposon insertions can initiate colorectal cancer and are associated with poor survival
- Article/chapterEnglish2019
Publisher, publication year, extent ...
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2019-09-06
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Springer Science and Business Media LLC,2019
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:141783684
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http://kipublications.ki.se/Default.aspx?queryparsed=id:141783684URI
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https://doi.org/10.1038/s41467-019-11770-0DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Genomic instability pathways in colorectal cancer (CRC) have been extensively studied, but the role of retrotransposition in colorectal carcinogenesis remains poorly understood. Although retrotransposons are usually repressed, they become active in several human cancers, in particular those of the gastrointestinal tract. Here we characterize retrotransposon insertions in 202 colorectal tumor whole genomes and investigate their associations with molecular and clinical characteristics. We find highly variable retrotransposon activity among tumors and identify recurrent insertions in 15 known cancer genes. In approximately 1% of the cases we identify insertions in APC, likely to be tumor-initiating events. Insertions are positively associated with the CpG island methylator phenotype and the genomic fraction of allelic imbalance. Clinically, high number of insertions is independently associated with poor disease-specific survival.
Added entries (persons, corporate bodies, meetings, titles ...)
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Sulo, P
(author)
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Tanskanen, T
(author)
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Katainen, R
(author)
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Taira, A
(author)
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Hanninen, UA
(author)
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Kondelin, J
(author)
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Forsstrom, L
(author)
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Valimaki, N
(author)
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Aavikko, M
(author)
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Kaasinen, E
(author)
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Ristimaki, A
(author)
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Koskensalo, S
(author)
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Lepisto, A
(author)
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Renkonen-Sinisalo, L
(author)
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Seppala, T
(author)
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Kuopio, T
(author)
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Bohm, J
(author)
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Mecklin, JP
(author)
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Kilpivaara, O
(author)
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Pitkanen, E
(author)
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Palin, K
(author)
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Aaltonen, LAKarolinska Institutet
(author)
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Karolinska Institutet
(creator_code:org_t)
Related titles
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In:Nature communications: Springer Science and Business Media LLC10:1, s. 4022-2041-1723
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Cajuso, T
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Sulo, P
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Tanskanen, T
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Katainen, R
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Taira, A
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Hanninen, UA
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show more...
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Kondelin, J
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Forsstrom, L
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Valimaki, N
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Aavikko, M
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Kaasinen, E
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Ristimaki, A
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Koskensalo, S
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Lepisto, A
-
Renkonen-Sinisal ...
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Seppala, T
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Kuopio, T
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Bohm, J
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Mecklin, JP
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Kilpivaara, O
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Pitkanen, E
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Palin, K
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Aaltonen, LA
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Nature communica ...
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Karolinska Institutet