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Genome-wide associa...
Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria
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- Teumer, A (author)
- Univ Med Greifswald, Inst Community Med, Greifswald, Germany;DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany
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- Li, Y (author)
- Univ Freiburg, Fac Med & Med Ctr, Dept Biometry Epidemiol & Med Bioinformat, Inst Genet Epidemiol, Freiburg, Germany
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- Ghasemi, S (author)
- Univ Med Greifswald, Inst Community Med, Greifswald, Germany;DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany
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- Prins, BP (author)
- Univ Cambridge, Dept Publ Hlth & Primary Care, MRC BHF Cardiovasc Epidemiol Unit, Cambridge, England,Geneva Univ Hosp, Serv Nephrol, Geneva, Switzerland
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- Wuttke, M (author)
- Univ Freiburg, Fac Med & Med Ctr, Dept Biometry Epidemiol & Med Bioinformat, Inst Genet Epidemiol, Freiburg, Germany;Univ Freiburg, Fac Med & Med Ctr, Dept Med, Renal Div, Freiburg, Germany
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- Hermle, T (author)
- Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA;Welch Ctr Prevent, Epidemiol & Clin Res, Baltimore, MD USA,Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands
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- Giri, A (author)
- Vanderbilt Univ, Med Ctr,Div Quantitat Sci, Dept Obstet & Gynecol,Vanderbilt Genet Inst, Inst Med & Publ Hlth,Vanderbilt Epidemiol Ctr, Nashville, TN 37232 USA;Vanderbilt Univ, Tennessee Valley Healthcare Syst 626, Biomed Lab Res & Dev, 221 Kirkland Hall, Nashville, TN 37235 USA,Univ Med Ctr Rotterdam, Erasmus MC, Dept Internal Med, Rotterdam, Netherlands
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- Sieber, KB (author)
- GlaxoSmithKline, Target Sci Genet, Collegeville, PA USA
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- Qiu, CX (author)
- Univ Penn, Dept Med, Dept Genet, Renal Elect & Hypertens,Div Perelman Sch Med, Philadelphia, PA 19104 USA
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- Kirsten, H (author)
- Univ Leipzig, Inst Med Informat Stat & Epidemiol, Leipzig, Germany;Univ Leipzig, LIFE Res Ctr Civilizat Dis, Leipzig, Germany
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- Tin, A (author)
- Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA;Welch Ctr Prevent, Epidemiol & Clin Res, Baltimore, MD USA
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- Chu, AY (author)
- Merck & Co Inc, Genet, Kenilworth, NJ USA
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- Bansal, N (author)
- Univ Washington, Div Nephrol, Seattle, WA 98195 USA;Univ Washington, Kidney Res Inst, Seattle, WA 98195 USA
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- Feitosa, MF (author)
- Washington Univ, Sch Med, Dept Genet, Div Stat Genom, St Louis, MO 63110 USA
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- Wang, L (author)
- Washington Univ, Sch Med, Dept Genet, Div Stat Genom, St Louis, MO 63110 USA
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- Chai, JF (author)
- Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore;Natl Univ Hlth Syst, Singapore, Singapore,Iceland Heart Assoc, Holtasmari 1, IS-201 Kopavogur, Iceland;Univ Iceland, Ctr Publ Hlth Sci, Sturlugata 8, IS-101 Reykjavik, Iceland
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- Cocca, M (author)
- IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, Trieste, Italy,Merck & Co Inc, MRL, Kenilworth, NJ USA;Celgene Inc, Cambridge, MA USA,Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA USA
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- Fuchsberger, C (author)
- Univ Lubeck, Inst Biomed, Eurac Res, Bolzano, Italy
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- Gorski, M (author)
- Univ Hosp Regensburg, Dept Nephrol, Regensburg, Germany;Univ Regensburg, Dept Genet Epidemiol, Regensburg, Germany
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- Hoppmann, A (author)
- Univ Freiburg, Fac Med & Med Ctr, Dept Biometry Epidemiol & Med Bioinformat, Inst Genet Epidemiol, Freiburg, Germany
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- Horn, K (author)
- Univ Leipzig, Inst Med Informat Stat & Epidemiol, Leipzig, Germany;Univ Leipzig, LIFE Res Ctr Civilizat Dis, Leipzig, Germany
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- Li, M (author)
- Univ Utah, Dept Med, Div Nephrol & Hypertens, Salt Lake City, UT 84112 USA,Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA;Univ Washington, Dept Biostat, Seattle, WA 98195 USA,Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore, Singapore
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- Marten, J (author)
- Univ Edinburgh, Inst Genet & Mol Med, Med Res Council Human Genet Unit, Edinburgh, Midlothian, Scotland
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- Noce, D (author)
- Univ Lubeck, Inst Biomed, Eurac Res, Bolzano, Italy
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- Nutile, T (author)
- CNR, Inst Genet & Biophys Adriano Buzzati Traveso, Naples, Italy
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- Sedaghat, S (author)
- Univ Med Ctr Rotterdam, Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands,Univ Cambridge, Dept Publ Hlth & Primary Care, MRC BHF Cardiovasc Epidemiol Unit, Cambridge, England;Univ Cambridge, Natl Inst Hlth Res Blood & Transplant Res Unit Do, Cambridge, England
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- Sveinbjornsson, G (author)
- Amgen Inc, deCODE Genet, Reykjavik, Iceland
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- Tayo, BO (author)
- Loyola Univ Chicago, Dept Publ Hlth Sci, Maywood, IL USA
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- Van der Most, PJ (author)
- Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands,Univ Lubeck, Inst Biomed, Eurac Res, Bolzano, Italy
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- Xu, YZ (author)
- Univ Utah, Dept Med, Div Nephrol & Hypertens, Salt Lake City, UT 84112 USA,Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA;Johns Hopkins Bloomberg Sch Publ Hlth, Dept Biostat, Baltimore, MD USA
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Yu, Z (author)
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- Gerstner, L (author)
- Univ Freiburg, Fac Med & Med Ctr, Dept Med, Renal Div, Freiburg, Germany
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- Ärnlöv, Johan, 1970- (author)
- Högskolan Dalarna,Karolinska Institutet,Karolinska Inst, Div Family Med & Primary Care, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden;Dalarna Univ, Sch Hlth & Social Studies, Falun, Sweden,Medicinsk vetenskap
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- Lind, Lars (author)
- Uppsala universitet,Klinisk epidemiologi,Vanderbilt Univ, Med Ctr, Dept Med, Div Epidemiol,Vanderbilt Genet Inst, Nashville, TN USA;Vanderbilt Univ, Tennessee Valley Healthcare Syst 626, Dept Vet Affairs, 221 Kirkland Hall, Nashville, TN 37235 USA
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- Baptista, D (author)
- Geneva Univ Hosp, Cardiol, Geneva, Switzerland
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- Biggs, ML (author)
- Univ Leipzig, Inst Med Informat Stat & Epidemiol, Leipzig, Germany;Univ Leipzig, LIFE Res Ctr Civilizat Dis, Leipzig, Germany
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- Boerwinkle, E (author)
- Univ Texas Hlth Sci Ctr Houston, Human Genet Ctr, Houston, TX 77030 USA
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- Brenner, H (author)
- German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany;Heidelberg Univ, Network Aging Res, Heidelberg, Germany,NIA, Lab Epidemiol & Populat Sci, Intramural Res Program, NIH, Bethesda, MD 20892 USA
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- Burkhardt, R (author)
- Univ Leipzig, LIFE Res Ctr Civilizat Dis, Leipzig, Germany;Univ Leipzig, Inst Lab Med Clin Chem & Mol Diagnost, Leipzig, Germany;Univ Hosp Regensburg, Inst Clin Chem & Lab Med, Regensburg, Germany
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- Carroll, RJ (author)
- Vanderbilt Univ, Med Ctr, Dept Biomed Informat, Nashville, TN USA,Univ Med Greifswald, Inst Physiol, Karlsburg, Germany
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- Chee, ML (author)
- Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore, Singapore,Univ Freiburg, Fac Med & Med Ctr, Dept Med, Renal Div, Freiburg, Germany
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Chee, ML (author)
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Chen, MM (author)
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- Cheng, CY (author)
- Natl Univ Hlth Syst, Singapore, Singapore;Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore, Singapore;Duke NUS Med Sch, Ophthalmol & Visual Sci Acad Clin Program Eye ACP, Singapore, Singapore;Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Ophthalmol, Singapore, Singapore
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- Cook, JP (author)
- Univ Liverpool, Dept Biostat, Liverpool, Merseyside, England
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- Coresh, J (author)
- Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA
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- Corre, T (author)
- Univ Lausanne, Ctr Primary Care & Publ Hlth Unisante, Lausanne, Switzerland;Univ Lausanne, Dept Computat Biol, Lausanne, Switzerland;Swiss Inst Bioinformat, Lausanne, Switzerland
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- Danesh, J (author)
- Univ Cambridge, Sch Clin Med, Dept Publ Hlth & Primary Care, Cambridge, England
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- de Borst, MH (author)
- Univ Groningen, Univ Med Ctr Groningen, Div Nephrol, Dept Internal Med, Groningen, Netherlands,Amgen Inc, deCODE Genet, Reykjavik, Iceland
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- De Grandi, A (author)
- Univ Lubeck, Inst Biomed, Eurac Res, Bolzano, Italy
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- de Mutsert, R (author)
- Leiden Univ, Med Ctr, Dept Clin Epidemiol, Leiden, Netherlands
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- de Vries, APJ (author)
- Leiden Univ, Med Ctr, Dept Internal Med, Sect Nephrol, Leiden, Netherlands,DZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, Munich, Germany;German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol, Neuherberg, Germany;German Ctr Diabet Res DZD, Neuherberg, Germany,NIDDK, Div Kidney Urol & Hematol Dis, NIH, Bethesda, MD 20892 USA;Univ Maryland, Sch Med, Dept Med, Baltimore, MD 21201 USA
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- Degenhardt, F (author)
- Christian Albrechts Univ Kiel, Inst Clin Mol Biol, Kiel, Germany
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- Dittrich, K (author)
- Univ Leipzig, Hosp Children & Adolescents, Dept Women & Child Hlth, Leipzig, Germany;Univ Leipzig, Ctr Pediat Res, Leipzig, Germany,Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Dept Pediat, Inst Translat Genom & Populat Sci, Torrance, CA 90509 USA
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- Divers, J (author)
- Wake Forest Sch Med, Dept Biostat & Data Sci, Winston Salem, NC USA
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- Eckardt, KU (author)
- Charite, Intens Care Med, Berlin, Germany;Friedrich Alexander Univ Erlangen Nurnberg FAU, Dept Nephrol & Hypertens, Erlangen, Germany
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- Ehret, G (author)
- Geneva Univ Hosp, Cardiol, Geneva, Switzerland
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- Endlich, K (author)
- DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany;Univ Med Greifswald, Dept Anat & Cell Biol, Greifswald, Germany
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- Felix, JF (author)
- Univ Med Ctr Rotterdam, Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands;Univ Med Ctr Rotterdam, Erasmus MC, Generat R Study Grp, Rotterdam, Netherlands;Univ Med Ctr Rotterdam, Erasmus MC, Dept Pediat, Rotterdam, Netherlands
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- Franco, OH (author)
- Univ Med Ctr Rotterdam, Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands;Univ Bern, ISPM, Bern, Switzerland
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- Franke, A (author)
- Christian Albrechts Univ Kiel, Inst Clin Mol Biol, Kiel, Germany
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- Freedman, BI (author)
- Wake Forest Sch Med, Internal Med Sect Nephrol, Winston Salem, NC USA
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- Freitag-Wolf, S (author)
- Univ Kiel, Univ Hosp Schleswig Holstein, Inst Med Informat & Stat, Kiel, Germany
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- Gansevoort, RT (author)
- Univ Groningen, Univ Med Ctr Groningen, Div Nephrol, Dept Internal Med, Groningen, Netherlands
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- Giedraitis, Vilmantas (author)
- Uppsala universitet,Geriatrik
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- Gogele, M (author)
- Univ Lubeck, Inst Biomed, Eurac Res, Bolzano, Italy
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- Grundner-Culemann, F (author)
- Univ Freiburg, Fac Med & Med Ctr, Dept Biometry Epidemiol & Med Bioinformat, Inst Genet Epidemiol, Freiburg, Germany
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- Gudbjartsson, DF (author)
- Amgen Inc, deCODE Genet, Reykjavik, Iceland
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- Gudnason, V (author)
- Iceland Heart Assoc, Kopavogur, Iceland;Univ Iceland, Sch Hlth Sci, Fac Med, Reykjavik, Iceland
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- Hamet, P (author)
- CHUM, Montreal Univ Hosp Res Ctr, Montreal, PQ, Canada;Medpharmgene, Montreal, PQ, Canada,Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands;Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands;Netherlands Heart Inst, Durrer Ctr Cardiovasc Res, Utrecht, Netherlands
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Harris, TB (author)
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- Hicks, AA (author)
- Univ Lubeck, Inst Biomed, Eurac Res, Bolzano, Italy
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Holm, H (author)
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- Foo, VHX (author)
- Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore, Singapore
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- Hwang, SJ (author)
- NHLBIs Framingham Heart Study, Framingham, MA USA;NHLBI, Ctr Populat Studies, Framingham, MA USA
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- Ikram, MA (author)
- Univ Med Ctr Rotterdam, Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands,Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England;Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England
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- Ingelsson, Erik, 1975- (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi,Stanford Univ, Sch Med, Div Cardiovasc Med, Dept Med, Stanford, CA 94305 USA;Stanford Univ, Stanford Cardiovasc Inst, Stanford, CA 94305 USA;Stanford Univ, Stanford Diabet Res Ctr, Stanford, CA 94305 USA
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- Jaddoe, VWV (author)
- Univ Med Ctr Rotterdam, Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands;Univ Med Ctr Rotterdam, Erasmus MC, Generat R Study Grp, Rotterdam, Netherlands;Univ Med Ctr Rotterdam, Erasmus MC, Dept Pediat, Rotterdam, Netherlands
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- Jakobsdottir, J (author)
- Leiden Univ, Med Ctr, Dept Internal Med, Sect Nephrol, Leiden, Netherlands;Leiden Univ, Med Ctr, Einthoven Lab Expt Vasc Res, Leiden, Netherlands
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- Josyula, NS (author)
- Geisinger Res Biomed & Translat Informat Inst, Rockville, MD USA
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- Jung, B (author)
- Univ Hosp Regensburg, Dept Nephrol, Regensburg, Germany
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- Kahonen, M (author)
- Tampere Univ Hosp, Dept Clin Physiol, Tampere, Finland;Tampere Univ, Fac Med & Hlth Technol, Finnish Cardiovasc Res Ctr Tampere, Dept Clin Physiol, Tampere, Finland
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- Khor, CC (author)
- Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore, Singapore;Agcy Sci Technol & Res, Genome Inst Singapore, Singapore, Singapore
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- Kiess, W (author)
- Univ Leipzig, LIFE Res Ctr Civilizat Dis, Leipzig, Germany;Univ Leipzig, Hosp Children & Adolescents, Dept Women & Child Hlth, Leipzig, Germany;Univ Leipzig, Ctr Pediat Res, Leipzig, Germany
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- Koenig, W (author)
- Tech Univ Munich, Deutsch Herzzentrum Munchen, Munich, Germany;DZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, Munich, Germany;Univ Ulm, Inst Epidemiol & Biostat, Ulm, Germany
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- Korner, A (author)
- Univ Leipzig, LIFE Res Ctr Civilizat Dis, Leipzig, Germany;Univ Leipzig, Hosp Children & Adolescents, Dept Women & Child Hlth, Leipzig, Germany;Univ Leipzig, Ctr Pediat Res, Leipzig, Germany
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- Kovacs, P (author)
- Univ Leipzig, Integrated Res & Treatment Ctr Adipos Dis, Leipzig, Germany
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- Kramer, H (author)
- Loyola Univ Chicago, Dept Publ Hlth Sci, Maywood, IL USA;Loyola Univ Chicago, Div Nephrol & Hypertens, Chicago, IL USA
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- Kramer, BK (author)
- Heidelberg Univ, Med Fac Mannheim, Dept Med Nephrol 5, Hypertensiol,Rheumatol,Endocrinol,Diabetol, Mannheim, Germany
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- Kronenberg, F (author)
- Med Univ Innsbruck, Dept Med Genet Mol & Clin Pharmacol, Div Genet Epidemiol, Innsbruck, Austria
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- Lange, LA (author)
- Univ Colorado Denver, Sch Med, Div Biomed Informat & Personalized Med, Anschutz Med Campus, Aurora, CO USA
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- Langefeld, CD (author)
- Wake Forest Sch Med, Dept Biostat & Data Sci, Winston Salem, NC USA
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- Lee, JJM (author)
- Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore;Natl Univ Hlth Syst, Singapore, Singapore
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- Lehtimaki, T (author)
- Fimlab Labs, Dept Clin Chem, Tampere, Finland;Tampere Univ, Fac Med & Hlth Technol, Finnish Cardiovasc Res Ctr Tampere, Dept Clin Chem, Tampere, Finland
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- Lieb, W (author)
- Univ Kiel, Inst Epidemiol, Kiel, Germany;Univ Kiel, Biobank Popgen, Kiel, Germany
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- Lim, SC (author)
- Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore;Natl Univ Hlth Syst, Singapore, Singapore;Khoo Teck Puat Hosp, Diabetes Ctr, Singapore, Singapore,Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore, Singapore;Duke NUS Med Sch, Ophthalmol & Visual Sci Acad Clin Program Eye ACP, Singapore, Singapore
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Lind, L (author)
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- Lindgren, CM (author)
- Univ Oxford, Nuffield Dept Med, Oxford, England;Broad Inst MIT & Harvard, Cambridge, MA 02142 USA,German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Independent Res Grp Clin Epidemiol, Neuherberg, Germany;Ludwig Maximilians Univ Munchen, UNIKA T Augsburg, Chair Epidemiol, Augsburg, Germany
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- Liu, JJ (author)
- Natl Univ Hlth Syst, Singapore, Singapore;Agcy Sci Technol & Res, Genome Inst Singapore, Singapore, Singapore;Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore, Singapore
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Loeffler, M (author)
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- Lyytikainen, LP (author)
- Fimlab Labs, Dept Clin Chem, Tampere, Finland;Tampere Univ, Fac Med & Hlth Technol, Finnish Cardiovasc Res Ctr Tampere, Dept Clin Chem, Tampere, Finland
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- Mahajan, A (author)
- Vanderbilt Univ, Med Ctr, Div Nephrol & Hypertens, Nashville, TN USA;Vanderbilt Univ, Tennessee Valley Healthcare Syst 626, Dept Vet Affairs, 221 Kirkland Hall, Nashville, TN 37235 USA
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Maranville, JC (author)
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- Mascalzoni, D (author)
- Univ Lubeck, Inst Biomed, Eurac Res, Bolzano, Italy
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- McMullen, B (author)
- Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA,Univ Washington, Dept Hlth Serv, Dept Epidemiol, Cardiovasc Hlth Res Unit,Dept Med, Seattle, WA 98195 USA;Kaiser Permanente, Washington Hlth Res Inst, Seattle, WA USA
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- Meisinger, C (author)
- Vanderbilt Univ, Med Ctr, Dept Biomed Informat, Nashville, TN USA
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- Meitinger, T (author)
- DZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, Munich, Germany;Helmholtz Zentrum Munchen, Inst Human Genet, Neuherberg, Germany;Tech Univ Munich, Inst Human Genet, Munich, Germany
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- Miliku, K (author)
- Univ Med Ctr Rotterdam, Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands;Univ Med Ctr Rotterdam, Erasmus MC, Generat R Study Grp, Rotterdam, Netherlands;Univ Med Ctr Rotterdam, Erasmus MC, Dept Pediat, Rotterdam, Netherlands,Univ Washington, Dept Biostat, Seattle, WA 98195 USA
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- Mook-Kanamori, DO (author)
- Leiden Univ, Med Ctr, Dept Clin Epidemiol, Leiden, Netherlands;Leiden Univ, Med Ctr, Dept Publ Hlth & Primary Care, Leiden, Netherlands,Univ Zurich, Inst Physiol, Zurich, Switzerland
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- Muller-Nurasyid, M (author)
- German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Genet Epidemiol, Neuherberg, Germany;LMU, Fac Med, IBE, Chair Genet Epidemiol, Munich, Germany;Hosp Ludwig Maximilians Univ LMU Munich, Dept Internal Med Cardiol 1, Munich, Germany
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Mychaleckyj, JC (author)
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- Nauck, M (author)
- DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany;Univ Med Greifswald, Inst Clin Chem & Lab Med, Greifswald, Germany
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- Nikus, K (author)
- Tampere Univ Hosp, Heart Ctr, Dept Cardiol, Tampere, Finland;Tampere Univ, Fac Med & Hlth Technol, Finnish Cardiovasc Res Ctr Tampere, Dept Cardiol, Tampere, Finland
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- Ning, B (author)
- Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA
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- Noordam, R (author)
- Leiden Univ, Med Ctr, Dept Internal Med, Sect Gerontol & Geriatr, Leiden, Netherlands
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- Connell, JO (author)
- Univ Maryland, Sch Med, Baltimore, MD 21201 USA
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- Olafsson, I (author)
- Landspitali Univ Hosp, Dept Clin Biochem, Reykjavik, Iceland
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- Palmer, ND (author)
- Wake Forest Sch Med, Biochem, Winston Salem, NC USA
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- Peters, A (author)
- Univ Liverpool, Dept Biostat, Liverpool, Merseyside, England;Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England
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- Podgornaia, AI (author)
- Merck & Co Inc, Genet, Kenilworth, NJ USA
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Ponte, B (author)
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- Poulain, T (author)
- Univ Leipzig, LIFE Res Ctr Civilizat Dis, Leipzig, Germany
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Pramstaller, PP (author)
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- Rabelink, TJ (author)
- Univ Leipzig, LIFE Res Ctr Civilizat Dis, Leipzig, Germany;Univ Leipzig, Inst Lab Med Clin Chem & Mol Diagnost, Leipzig, Germany,CHUM, Montreal Univ Hosp Res Ctr, Montreal, PQ, Canada;CRCHUM, Montreal, PQ, Canada
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- Raffield, LM (author)
- Univ N Carolina, Dept Genet, Chapel Hill, NC 27515 USA
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- Reilly, DF (author)
- Merck & Co Inc, Genet, Kenilworth, NJ USA
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Rettig, R (author)
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- Rheinberger, M (author)
- Univ Hosp Regensburg, Dept Nephrol, Regensburg, Germany
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Rice, KM (author)
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- Rivadeneira, F (author)
- Univ Med Ctr Rotterdam, Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands;Univ Med Ctr Rotterdam, Erasmus MC, Dept Internal Med, Rotterdam, Netherlands
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- Runz, H (author)
- Merck & Co Inc, MRL, Kenilworth, NJ USA;Biogen Inc, 14 Cambridge Ctr, Cambridge, MA 02142 USA
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- Ryan, KA (author)
- Univ Maryland, Sch Med, Div Endocrinol Diabet & Nutr, Baltimore, MD 21201 USA,Univ Freiburg, Fac Med & Med Ctr, Dept Biometry Epidemiol & Med Bioinformat, Inst Genet Epidemiol, Freiburg, Germany;Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA
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Sabanayagam, C (author)
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- Saum, KU (author)
- German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany
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- Schottker, B (author)
- German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany;Heidelberg Univ, Network Aging Res, Heidelberg, Germany
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Shaffer, CM (author)
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- Shi, Y (author)
- Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore, Singapore;Duke NUS Med Sch, Ophthalmol & Visual Sci Acad Clin Program Eye ACP, Singapore, Singapore
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- Smith, AV (author)
- Univ Iceland, Sch Hlth Sci, Fac Med, Reykjavik, Iceland
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- Strauch, K (author)
- German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Genet Epidemiol, Neuherberg, Germany;LMU, Fac Med, IBE, Chair Genet Epidemiol, Munich, Germany
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- Stumvoll, M (author)
- Univ Leipzig, Dept Endocrinol & Nephrol, Leipzig, Germany
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- Sun, BB (author)
- Univ Cambridge, Dept Publ Hlth & Primary Care, MRC BHF Cardiovasc Epidemiol Unit, Cambridge, England
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Szymczak, S (author)
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- Tai, ES (author)
- Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore;Natl Univ Hlth Syst, Singapore, Singapore;Natl Univ Hlth Syst, Singapore, Singapore;Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore, Singapore;Duke NUS Med Sch, Singapore, Singapore
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- Tan, NYQ (author)
- Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore, Singapore,Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA
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Taylor, KD (author)
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- Teren, A (author)
- Univ Leipzig, LIFE Res Ctr Civilizat Dis, Leipzig, Germany;Heart Ctr Leipzig, Leipzig, Germany
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Tham, YC (author)
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Thiery, J (author)
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Thio, CHL (author)
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- Thomsen, H (author)
- German Canc Res Ctr, Div Mol Genet Epidemiol, Heidelberg, Germany
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- Thorsteinsdottir, U (author)
- Amgen Inc, deCODE Genet, Reykjavik, Iceland
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- Tonjes, A (author)
- Univ Leipzig, Dept Endocrinol & Nephrol, Leipzig, Germany
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Tremblay, J (author)
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Uitterlinden, AG (author)
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Van der Harst, P (author)
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- Verweij, N (author)
- Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands
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- Vogelezang, S (author)
- Univ Med Ctr Rotterdam, Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands;Univ Med Ctr Rotterdam, Erasmus MC, Generat R Study Grp, Rotterdam, Netherlands;Univ Med Ctr Rotterdam, Erasmus MC, Dept Pediat, Rotterdam, Netherlands
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- Volker, U (author)
- DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany;Univ Med Greifswald, Interfac Inst Genet & Funct Genom, Greifswald, Germany
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- Waldenberger, M (author)
- DZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, Munich, Germany;German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol, Neuherberg, Germany;German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, Neuherberg, Germany
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- Wang, C (author)
- Agcy Sci Technol & Res, Genome Inst Singapore, Singapore, Singapore;Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Wuhan, Hubei, Peoples R China,Natl Univ Hlth Syst, Singapore, Singapore;Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Ophthalmol, Singapore, Singapore
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- Wilson, OD (author)
- Vanderbilt Univ, Med Ctr, Div Nephrol & Hypertens, Nashville, TN USA
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Wong, C (author)
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- Wong, TY (author)
- Natl Univ Hlth Syst, Singapore, Singapore;Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore, Singapore;Duke NUS Med Sch, Ophthalmol & Visual Sci Acad Clin Program Eye ACP, Singapore, Singapore;Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Ophthalmol, Singapore, Singapore
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Yang, Q (author)
-
- Yasuda, M (author)
- Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore, Singapore;Tohoku Univ, Grad Sch Med, Dept Ophthalmol, Sendai, Miyagi, Japan
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- Akilesh, S (author)
- Univ Washington, Kidney Res Inst, Seattle, WA 98195 USA;Univ Washington, Med Ctr, Anat Pathol, Seattle, WA 98195 USA,Geisinger Res, Biomed & Translat Informat Inst, Danville, PA USA
-
- Bochud, M (author)
- Univ Lausanne, Ctr Primary Care & Publ Hlth Unisante, Lausanne, Switzerland
-
- Boger, CA (author)
- Univ Hosp Regensburg, Dept Nephrol, Regensburg, Germany;Kliniken Sudostbayern, Dept Nephrol Diabetol & Rheumatol, Traunstein, Germany
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Devuyst, O (author)
-
Edwards, TL (author)
-
- Ho, K (author)
- Geisinger, KHRI, Danville, PA USA;Geisinger, Dept Nephrol, Danville, PA USA
-
Morris, AP (author)
-
Parsa, A (author)
-
Pendergrass, SA (author)
-
Psaty, BM (author)
-
- Rotter, JI (author)
- Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Dept Pediat, Inst Translat Genom & Populat Sci, Torrance, CA 90509 USA;Harbor UCLA Med Ctr, Dept Pediat, Torrance, CA 90509 USA;Harbor UCLA Med Ctr, Dept Med, Torrance, CA 90509 USA
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- Stefansson, K (author)
- Amgen Inc, deCODE Genet, Reykjavik, Iceland
-
- Wilson, JG (author)
- Univ Mississippi, Med Ctr, Dept Phys & Biophys, Jackson, MS 39216 USA
-
- Susztak, K (author)
- Univ Penn, Dept Med, Dept Genet, Renal Elect & Hypertens,Div Perelman Sch Med, Philadelphia, PA 19104 USA
-
- Snieder, H (author)
- Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands
-
- Heid, IM (author)
- Univ Regensburg, Dept Genet Epidemiol, Regensburg, Germany
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- Scholz, M (author)
- Univ Leipzig, Inst Med Informat Stat & Epidemiol, Leipzig, Germany;Univ Leipzig, LIFE Res Ctr Civilizat Dis, Leipzig, Germany
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Butterworth, AS (author)
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Hung, AM (author)
-
- Pattaro, C (author)
- Univ Lubeck, Inst Biomed, Eurac Res, Bolzano, Italy
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Kottgen, A (author)
-
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-
(creator_code:org_t)
- 2019-09-11
- 2019
- English.
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In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 4130-
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Abstract
Subject headings
Close
- Increased levels of the urinary albumin-to-creatinine ratio (UACR) are associated with higher risk of kidney disease progression and cardiovascular events, but underlying mechanisms are incompletely understood. Here, we conduct trans-ethnic (n = 564,257) and European-ancestry specific meta-analyses of genome-wide association studies of UACR, including ancestry- and diabetes-specific analyses, and identify 68 UACR-associated loci. Genetic correlation analyses and risk score associations in an independent electronic medical records database (n = 192,868) reveal connections with proteinuria, hyperlipidemia, gout, and hypertension. Fine-mapping and trans-Omics analyses with gene expression in 47 tissues and plasma protein levels implicate genes potentially operating through differential expression in kidney (including TGFB1, MUC1, PRKCI, and OAF), and allow coupling of UACR associations to altered plasma OAF concentrations. Knockdown of OAF and PRKCI orthologs in Drosophila nephrocytes reduces albumin endocytosis. Silencing fly PRKCI further impairs slit diaphragm formation. These results generate a priority list of genes and pathways for translational research to reduce albuminuria.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- Hälsa och välfärd
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- ref (subject category)
- art (subject category)
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Teumer, A
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Li, Y
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Ghasemi, S
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Prins, BP
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Wuttke, M
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Hermle, T
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Giri, A
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Sieber, KB
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Qiu, CX
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Kirsten, H
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Tin, A
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Bansal, N
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Feitosa, MF
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Wang, L
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Chai, JF
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Cocca, M
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Fuchsberger, C
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Gorski, M
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Hoppmann, A
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Horn, K
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Li, M
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Marten, J
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Noce, D
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Nutile, T
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Sedaghat, S
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Sveinbjornsson, ...
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Tayo, BO
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Van der Most, PJ
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Xu, YZ
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Yu, Z
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Gerstner, L
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Ärnlöv, Johan, 1 ...
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Lind, Lars
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Baptista, D
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Biggs, ML
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Boerwinkle, E
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Brenner, H
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Burkhardt, R
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Carroll, RJ
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Chee, ML
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Chen, MM
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Cheng, CY
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Cook, JP
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Coresh, J
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Corre, T
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Danesh, J
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de Borst, MH
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De Grandi, A
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de Mutsert, R
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de Vries, APJ
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Degenhardt, F
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Dittrich, K
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Divers, J
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Eckardt, KU
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Ehret, G
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Endlich, K
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Felix, JF
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Franco, OH
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Franke, A
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Freedman, BI
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Freitag-Wolf, S
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Gansevoort, RT
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Giedraitis, Vilm ...
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Gogele, M
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Grundner-Culeman ...
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Gudbjartsson, DF
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Gudnason, V
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Hamet, P
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Harris, TB
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Hicks, AA
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Holm, H
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Foo, VHX
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Hwang, SJ
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Ikram, MA
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Ingelsson, Erik, ...
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Jaddoe, VWV
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Jakobsdottir, J
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Josyula, NS
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Jung, B
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Kahonen, M
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Khor, CC
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Kiess, W
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Koenig, W
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Korner, A
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Kovacs, P
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Kramer, H
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Kramer, BK
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Kronenberg, F
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Lange, LA
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Langefeld, CD
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Lee, JJM
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Lehtimaki, T
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Lieb, W
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Lim, SC
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Lind, L
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Lindgren, CM
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Liu, JJ
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Loeffler, M
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Lyytikainen, LP
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Mahajan, A
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Maranville, JC
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Mascalzoni, D
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McMullen, B
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Meisinger, C
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Meitinger, T
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Miliku, K
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Mook-Kanamori, D ...
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Muller-Nurasyid, ...
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Mychaleckyj, JC
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Nauck, M
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Nikus, K
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Ning, B
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Noordam, R
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Connell, JO
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Olafsson, I
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Palmer, ND
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Peters, A
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Podgornaia, AI
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Ponte, B
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Poulain, T
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Pramstaller, PP
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Rabelink, TJ
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Raffield, LM
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Reilly, DF
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Rettig, R
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Rheinberger, M
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Rice, KM
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Rivadeneira, F
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Runz, H
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Ryan, KA
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Sabanayagam, C
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Saum, KU
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Schottker, B
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Shaffer, CM
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Shi, Y
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Smith, AV
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Strauch, K
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Stumvoll, M
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Sun, BB
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Szymczak, S
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Tai, ES
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Tan, NYQ
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Taylor, KD
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Teren, A
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Tham, YC
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Thiery, J
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Thio, CHL
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Thomsen, H
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Thorsteinsdottir ...
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Tonjes, A
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Tremblay, J
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Uitterlinden, AG
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Van der Harst, P
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Verweij, N
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Vogelezang, S
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Volker, U
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Waldenberger, M
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Wang, C
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Wilson, OD
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Wong, C
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Wong, TY
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Yang, Q
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Yasuda, M
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Akilesh, S
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Bochud, M
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Boger, CA
-
Devuyst, O
-
Edwards, TL
-
Ho, K
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Morris, AP
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Parsa, A
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Pendergrass, SA
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Psaty, BM
-
Rotter, JI
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Stefansson, K
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Wilson, JG
-
Susztak, K
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Snieder, H
-
Heid, IM
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Scholz, M
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Butterworth, AS
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Hung, AM
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Pattaro, C
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Kottgen, A
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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Nature communica ...
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Karolinska Institutet
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Uppsala University
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Högskolan Dalarna