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  • Tesfaye, FregenetLund University,Lunds universitet,Klinisk infektionsmedicin,Forskargrupper vid Lunds universitet,Clinical infection medicine,Lund University Research Groups,Armauer Hansen Research Institute (author)

Longitudinal Mycobacterium tuberculosis-specific Interferon Gamma responses in Ethiopian HIV-negative women during pregnancy and postpartum

  • Article/chapterEnglish2021

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  • 2021

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  • LIBRIS-ID:oai:lup.lub.lu.se:cfbac72e-1585-4a86-a74f-f707d3eb07e0
  • https://lup.lub.lu.se/record/cfbac72e-1585-4a86-a74f-f707d3eb07e0URI
  • https://doi.org/10.1128/JCM.00868-21DOI

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  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Pregnancy may influence cellular immune responses to Mycobacterium tuberculosis. We investigated M. tuberculosis-specific interferon-g responses in women followed longitudinally during pregnancy and postpartum. Interferon-g levels (stimulated by M. tuberculosis antigens [TB1 and TB2] and mitogen included in the QuantiFERON-TB Gold Plus assay) were measured in blood from pregnant HIV-negative women identified from a prospective cohort at Ethiopian antenatal care clinics. Longitudinal comparisons included women without active tuberculosis (TB) with M. tuberculosis-triggered interferon-g responses of $ 0.20 IU/ml, sampled on two and/or three occasions (1st/2nd trimester, 3rd trimester, and 9 months postpartum). Among 2,093 women in the source cohort, 363 met inclusion criteria for longitudinal comparisons of M. tuberculosis-stimulated interferon-g responses. Median M. tuberculosis-triggered interferon-g concentrations were higher at 3rd than those at the 1st/2nd trimester (in 38 women with samples available from these time points; TB1: 2.8 versus 1.6 IU/ml, P = 0.005; TB2: 3.3 versus 2.8 IU/ml, P = 0.03) and postpartum (in 49 women with samples available from these time points; TB1: 3.1 versus 2.2 IU/ml, P = 0.01; TB2: 3.1 versus 2.3 IU/ml, P = 0.03). In contrast, mitogen-stimulated interferon-g levels were lower at 3rd than those at 1st/2nd trimester (in 32 women with samples available from these time points: 21.0 versus 34.9 IU/ml, P = 0.02). Results were similar in 22 women sampled on all 3 occasions. In HIV-negative women, M. tuberculosis-stimulated interferon-g responses were higher during the 3rd trimester than those at earlier stages of pregnancy and postpartum, despite decreased mitogen-triggered responses. These findings suggest increased M. tuberculosis-specific cellular responses due to dynamic changes of latent TB infection during pregnancy.

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  • Walles, JohnLund University,Lunds universitet,Klinisk infektionsmedicin,Forskargrupper vid Lunds universitet,Clinical infection medicine,Lund University Research Groups,Central Hospital Kristianstad(Swepub:lu)jo5222ko (author)
  • Sturegård, ErikLund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Department of Translational Medicine,Faculty of Medicine,Clinical Microbiology, Malmö,Lund University Research Groups(Swepub:lu)mmb-est (author)
  • Winqvist, NiclasLund University,Lunds universitet,Klinisk infektionsmedicin,Forskargrupper vid Lunds universitet,Clinical infection medicine,Lund University Research Groups(Swepub:lu)med-nwt (author)
  • Balcha, Taye ToleraLund University,Lunds universitet,Klinisk infektionsmedicin,Forskargrupper vid Lunds universitet,Clinical infection medicine,Lund University Research Groups(Swepub:lu)med-ttb (author)
  • Kefeni, MestawetAdama Public Health Research and Referral Laboratory Center (author)
  • Jansson, MarianneLund University,Lunds universitet,Avdelningen för medicinsk mikrobiologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,HIV-1 och HIV-2 värd interaktioner,Forskargrupper vid Lunds universitet,Division of Medical Microbiology,Department of Laboratory Medicine,Faculty of Medicine,HIV-1 and HIV-2 host interactions,Lund University Research Groups(Swepub:lu)mmb-mj0 (author)
  • Björkman, PerLund University,Lunds universitet,Klinisk infektionsmedicin,Forskargrupper vid Lunds universitet,Clinical infection medicine,Lund University Research Groups,Skåne University Hospital(Swepub:lu)inf-pbj (author)
  • Klinisk infektionsmedicinForskargrupper vid Lunds universitet (creator_code:org_t)

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  • In:Journal of Clinical Microbiology59:100095-1137

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