Plasma Metabolic Signature and Abnormalities in HIV-Infected Individuals on Long-Term Successful Antiretroviral Therapy

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Babu, H (author)

Plasma Metabolic Signature and Abnormalities in HIV-Infected Individuals on Long-Term Successful Antiretroviral Therapy

Article/chapterEnglish2019

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2019-09-30
MDPI AG,2019

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LIBRIS-ID:oai:prod.swepub.kib.ki.se:142187771
http://kipublications.ki.se/Default.aspx?queryparsed=id:142187771URI
https://doi.org/10.3390/metabo9100210DOI

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Language:English
Summary in:English

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Targeted metabolomics studies reported metabolic abnormalities in both treated and untreated people living with human immunodeficiency virus (HIV) (PLHIV). The present study aimed to understand the plasma metabolomic changes and predicted the risk of accelerated aging in PLHIV on long-term suppressive antiretroviral therapy (ART) in a case-control study setting and its association with the plasma proteomics biomarkers of inflammation and neurological defects. Plasma samples were obtained from PLHIV on successful long-term ART for more than five years (n = 22) and matched HIV-negative healthy individuals (n = 22, HC herein). Untargeted metabolite profiling was carried out using ultra-high-performance liquid chromatography/mass spectrometry/mass spectrometry (UHPLC/MS/MS). Plasma proteomics profiling was performed using proximity extension assay targeting 184 plasma proteins. A total of 250 metabolites differed significantly (p < 0.05, q < 0.1) between PLHIV and HC. Plasma levels of several essential amino acids except for histidine, branched-chain amino acids, and aromatic amino acids (phenylalanine, tyrosine, tryptophan) were significantly lower in PLHIV compared to HC. Machine-learning prediction of metabolite changes indicated a higher risk of inflammatory and neurological diseases in PLHIV. Metabolic abnormalities were observed in amino-acid levels, energetics, and phospholipids and complex lipids, which may reflect known differences in lipoprotein levels in PLHIV that can resemble metabolic syndrome (MetS).

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Sperk, MKarolinska Institutet (author)
Ambikan, ATKarolinska Institutet (author)
Rachel, G (author)
Viswanathan, VK (author)
Tripathy, SP (author)
Nowak, PKarolinska Institutet (author)
Hanna, LE (author)
Neogi, UKarolinska Institutet (author)
Karolinska Institutet (creator_code:org_t)

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In:Metabolites: MDPI AG9:102218-1989

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By the author/editor: Babu, H; Sperk, M; Ambikan, AT; Rachel, G; Viswanathan, VK; Tripathy, SP; show more...; Nowak, P; Hanna, LE; Neogi, U; show less...

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