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Tissue immune profi...
Tissue immune profiles supporting response to mesenchymal stromal cell therapy in acute graft-versus-host disease-a gut feeling
- Article/chapterEnglish2019
Publisher, publication year, extent ...
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2019-11-20
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Springer Science and Business Media LLC,2019
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:142334808
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http://kipublications.ki.se/Default.aspx?queryparsed=id:142334808URI
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https://doi.org/10.1186/s13287-019-1449-9DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:vet swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Acute graft-versus-host disease (aGvHD), post-allogeneic hematopoietic stem cell transplantation, is associated with high mortality rates in patients not responding to standard line care with steroids. Adoptive mesenchymal stromal cell (MSC) therapy has been established in some countries as a second-line treatment.Limitations in our understanding as to MSC mode of action and what segregates patient responders from non-responders to MSC therapy remain. The principal aim of this study was to evaluate the immune cell profile in gut biopsies of patients diagnosed with aGvHD and establish differences in baseline cellular composition between responders and non-responders to subsequent MSC therapy.Our findings indicate that a pro-inflammatory immune profile within the gut at the point of MSC treatment may impede their therapeutic potential. These findings support the need for further validation in a larger cohort of patients and the development of improved biomarkers in predicting responsiveness to MSC therapy.
Added entries (persons, corporate bodies, meetings, titles ...)
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Boberg, EKarolinska Institutet
(author)
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Von Bahr, L
(author)
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Bottai, MKarolinska Institutet
(author)
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Andren, AT
(author)
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Wernerson, AKarolinska Institutet
(author)
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Davies, LC
(author)
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Sugars, RVKarolinska Institutet
(author)
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Le Blanc, KKarolinska Institutet
(author)
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Karolinska Institutet
(creator_code:org_t)
Related titles
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In:Stem cell research & therapy: Springer Science and Business Media LLC10:1, s. 334-1757-6512
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