Sökning: (WFRF:(Pierce D.)) srt2:(2015-2019)
> (2019) >
Circulating vitamin...
Circulating vitamin D concentrations and risk of breast and prostate cancer: a Mendelian randomization study
-
- Jiang, X (författare)
- Karolinska Institutet
-
Dimou, NL (författare)
-
Al-Dabhani, K (författare)
-
visa fler...
-
Lewis, SJ (författare)
-
Martin, RM (författare)
-
Haycock, PC (författare)
-
Gunter, MJ (författare)
-
Key, TJ (författare)
-
Eeles, RA (författare)
-
Muir, K (författare)
-
Neal, D (författare)
-
Giles, GG (författare)
-
Giovannucci, EL (författare)
-
Stampfer, M (författare)
-
Pierce, BL (författare)
-
Schildkraut, JM (författare)
-
Andersen, SW (författare)
-
Thompson, D (författare)
-
Zheng, W (författare)
-
Kraft, P (författare)
-
Tsilidis, KK (författare)
-
visa färre...
-
(creator_code:org_t)
- 2018-12-28
- 2019
- Engelska.
-
Ingår i: International journal of epidemiology. - : Oxford University Press (OUP). - 1464-3685 .- 0300-5771. ; 48:5, s. 1416-1424
- Relaterad länk:
-
https://academic.oup...
-
visa fler...
-
http://kipublication...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- BackgroundObservational studies have suggested an association between circulating vitamin D concentrations [25(OH)D] and risk of breast and prostate cancer, which was not supported by a recent Mendelian randomization (MR) analysis comprising 15 748 breast and 22 898 prostate-cancer cases. Demonstrating causality has proven challenging and one common limitation of MR studies is insufficient power.MethodsWe aimed to determine whether circulating concentrations of vitamin D are causally associated with the risk of breast and prostate cancer, by using summary-level data from the largest ever genome-wide association studies conducted on vitamin D (N = 73 699), breast cancer (Ncase = 122 977) and prostate cancer (Ncase = 79 148). We constructed a stronger instrument using six common genetic variants (compared with the previous four variants) and applied several two-sample MR methods.ResultsWe found no evidence to support a causal association between 25(OH)D and risk of breast cancer [OR per 25 nmol/L increase, 1.02 (95% confidence interval: 0.97–1.08), P = 0.47], oestrogen receptor (ER)+ [1.00 (0.94–1.07), P = 0.99] or ER− [1.02 (0.90–1.16), P = 0.75] subsets, prostate cancer [1.00 (0.93–1.07), P = 0.99] or the advanced subtype [1.02 (0.90–1.16), P = 0.72] using the inverse-variance-weighted method. Sensitivity analyses did not reveal any sign of directional pleiotropy.ConclusionsDespite its almost five-fold augmented sample size and substantially improved statistical power, our MR analysis does not support a causal effect of circulating 25(OH)D concentrations on breast- or prostate-cancer risk. However, we can still not exclude a modest or non-linear effect of vitamin D. Future studies may be designed to understand the effect of vitamin D in subpopulations with a profound deficiency.
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Jiang, X
-
Dimou, NL
-
Al-Dabhani, K
-
Lewis, SJ
-
Martin, RM
-
Haycock, PC
-
visa fler...
-
Gunter, MJ
-
Key, TJ
-
Eeles, RA
-
Muir, K
-
Neal, D
-
Giles, GG
-
Giovannucci, EL
-
Stampfer, M
-
Pierce, BL
-
Schildkraut, JM
-
Andersen, SW
-
Thompson, D
-
Zheng, W
-
Kraft, P
-
Tsilidis, KK
-
visa färre...
- Artiklar i publikationen
-
International jo ...
- Av lärosätet
-
Karolinska Institutet