Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder

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MARC

de Jong, S (author)

Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder

Article/chapterEnglish2018

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2018-10-08
Springer Science and Business Media LLC,2018

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LIBRIS-ID:oai:prod.swepub.kib.ki.se:142655749
http://kipublications.ki.se/Default.aspx?queryparsed=id:142655749URI
https://doi.org/10.1038/s42003-018-0155-yDOI
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-157800URI
https://gup.ub.gu.se/publication/273609URI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

Notes

Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk scores to also highlight patterns of common genetic risk. We analyze polygenic risk scores for psychiatric disorders in a large pedigree (n ~ 260) in which 30% of family members suffer from major depressive disorder or bipolar disorder. Studying patterns of assortative mating and anticipation, it appears increased polygenic risk is contributed by affected individuals who married into the family, resulting in an increasing genetic risk over generations. This may explain the observation of anticipation in mood disorders, whereby onset is earlier and the severity increases over the generations of a family. Joint analyses of rare and common variation may be a powerful way to understand the familial genetics of psychiatric disorders.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Psykiatri hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Psychiatry hsv//eng

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Diniz, MJAKarolinska Institutet (author)
Saloma, A (author)
Gadelha, A (author)
Landén, Mikael,1966Gothenburg University,Göteborgs universitet,Karolinska Institutet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xlandt (author)
Ota, VK (author)
Noto, C (author)
Curtis, C (author)
Newhouse, SJ (author)
Patel, H (author)
Hall, LS (author)
O'Reilly, PF (author)
Belangero, SI (author)
Adolfsson, RolfUmeå universitet,Psykiatri(Swepub:umu)road0001 (author)
Breen, G (author)
Wray, NR (author)
Ripke, S (author)
Mattheisen, MKarolinska Institutet (author)
Trzaskowski, M (author)
Byrne, EM (author)
Abdellaoui, AKarolinska Institutet (author)
Adams, MJ (author)
Agerbo, E (author)
Air, TM (author)
Andlauer, TFM (author)
Bacanu, SA (author)
Baekvad-Hansen, M (author)
Beekman, ATF (author)
Bigdeli, TB (author)
Binder, EB (author)
Blackwood, DHR (author)
Bryois, JKarolinska Institutet (author)
Buttenschon, HN (author)
Bybjerg-Grauholm, J (author)
Cai, N (author)
Castelao, E (author)
Christensen, JH (author)
Clarke, TK (author)
Coleman, JRI (author)
Colodro-Conde, L (author)
Couvy-Duchesne, B (author)
Craddock, N (author)
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Davies, G (author)
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Degenhardt, F (author)
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Dunn, EC (author)
Eley, TC (author)
Escott-Price, V (author)
Kiadeh, FFH (author)
Finucane, HK (author)
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Gaspar, HA (author)
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Goes, FS (author)
Gordon, SD (author)
Grove, J (author)
Hansen, CS (author)
Hansen, TF (author)
Herms, S (author)
Hickie, IB (author)
Hoffmann, P (author)
Homuth, G (author)
Horn, C (author)
Hottenga, JJ (author)
Hougaard, DM (author)
Ising, M (author)
Jansen, R (author)
Jones, I (author)
Jones, LA (author)
Jorgenson, E (author)
Knowles, JA (author)
Kohane, IS (author)
Kraft, J (author)
Kretzschmar, WW (author)
Krogh, J (author)
Kutalik, Z (author)
Li, YH (author)
Lind, PA (author)
MacIntyre, DJ (author)
MacKinnon, DF (author)
Maier, RM (author)
Maier, W (author)
Marchini, J (author)
Mbarek, H (author)
McGrath, P (author)
McGuffin, P (author)
Medland, SE (author)
Mehta, D (author)
Middeldorp, CM (author)
Mihailov, E (author)
Milaneschi, Y (author)
Milani, L (author)
Mondimore, FM (author)
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Mostafavi, S (author)
Mullins, N (author)
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Ng, B (author)
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Oskarsson, H (author)
Owen, MJ (author)
Painter, JN (author)
Pedersen, CB (author)
Pedersen, MG (author)
Peterson, REKarolinska Institutet (author)
Pettersson, EKarolinska Institutet (author)
Peyrot, WJ (author)
Pistis, G (author)
Posthuma, D (author)
Quiroz, JA (author)
Qvist, P (author)
Rice, JP (author)
Riley, BP (author)
Rivera, M (author)
Mirza, SS (author)
Schoevers, R (author)
Schulte, EC (author)
Shen, L (author)
Shyn, SI (author)
Sigurdsson, EKarolinska Institutet (author)
Sinnamon, GCB (author)
Smit, JH (author)
Smith, DJ (author)
Stefansson, H (author)
Steinberg, S (author)
Streit, F (author)
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Treutlein, J (author)
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Uitterlinden, AG (author)
Umbricht, D (author)
Van der Auwera, S (author)
van Hemert, AM (author)
Viktorin, AKarolinska Institutet (author)
Visscher, PM (author)
Wang, YP (author)
Webb, BT (author)
Weinsheimer, SM (author)
Wellmann, J (author)
Willemsen, G (author)
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Baune, BT (author)
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Boomsma, DI (author)
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de Geus, EJC (author)
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Domenici, E (author)
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Heath, AC (author)
Kendler, KS (author)
Kloiber, S (author)
Lewis, G (author)
Li, QQS (author)
Lucae, S (author)
Madden, PAF (author)
Magnusson, PKKarolinska Institutet (author)
Martin, NG (author)
McIntosh, AM (author)
Metspalu, A (author)
Mors, O (author)
Mortensen, PB (author)
Muller-Myhsok, B (author)
Nordentoft, M (author)
Nothen, MM (author)
O'Donovan, MC (author)
Paciga, SA (author)
Pedersen, NLKarolinska Institutet (author)
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Perlis, RH (author)
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Preisig, M (author)
Rietschel, M (author)
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Levinson, DFKarolinska Institutet (author)
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Sullivan, PFKarolinska Institutet (author)
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Strauss, J (author)
Xu, W (author)
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Thompson, RC (author)
Meng, FG (author)
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Moran, J (author)
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Melle, I (author)
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Nordin Adolfsson, AnnelieUmeå universitet,Psykiatri(Swepub:umu)anenon01 (author)
Anjorin, A (author)
Kandaswamy, R (author)
Lawrence, J (author)
McLean, AW (author)
Pickard, BS (author)
Bergen, SEKarolinska Institutet (author)
Nimgaonkar, V (author)
Landen, MKarolinska Institutet (author)
Schalling, MKarolinska Institutet (author)
Osby, U (author)
Backlund, LKarolinska Institutet (author)
Frisen, LKarolinska Institutet (author)
Langstrom, NKarolinska Institutet (author)
Stahl, E (author)
Dobbyn, A (author)
Jamain, S (author)
Etain, B (author)
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Kittel-Schneider, S (author)
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Oruc, L (author)
Para, JG (author)
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Rivas, F (author)
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Pfennig, A (author)
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Kogevinas, M (author)
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Bauer, M (author)
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Hautzinger, M (author)
Kelsoe, JR (author)
Greenwood, TA (author)
Nievergelt, CM (author)
Shilling, PD (author)
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Bloss, CS (author)
Edenberg, HJ (author)
Koller, DL (author)
Gershon, ES (author)
Liu, CY (author)
Badner, JA (author)
Scheftner, WA (author)
Lawson, WB (author)
Nwulia, EA (author)
Hipolito, M (author)
Coryell, W (author)
Rice, J (author)
Byerley, W (author)
McMahon, FJ (author)
Lohoff, FW (author)
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Szelinger, S (author)
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Fraser, C (author)
Green, EK (author)
Grozeva, D (author)
Hamshere, ML (author)
Kirov, G (author)
Nikolov, I (author)
Collier, DA (author)
Elkin, A (author)
Williamson, R (author)
Young, AH (author)
Ferrier, IN (author)
Milanova, V (author)
Alda, M (author)
Cervantes, P (author)
Cruceanu, C (author)
Rouleau, GA (author)
Turecki, G (author)
Paciga, S (author)
Winslow, AR (author)
Grigoroiu-Serbanescu, M (author)
Ophoff, R (author)
Adolfsson, R (author)
Adolfsson, AN (author)
Del-Favero, J (author)
Pato, C (author)
Biernacka, JM (author)
Frye, MA (author)
Morris, D (author)
Schork, NJ (author)
Reif, A (author)
Lissowska, J (author)
Hauser, J (author)
Szeszenia-Dabrowska, N (author)
McGhee, K (author)
Quinn, E (author)
Moskvina, V (author)
Holmans, PA (author)
Farmer, A (author)
Kennedy, JL (author)
Andreassen, OA (author)
Mattingsdal, M (author)
Bass, NJ (author)
Gurling, H (author)
McQuillin, A (author)
Breuer, R (author)
Hultman, C (author)
Lichtenstein, PKarolinska Institutet (author)
Huckins, LM (author)
Leboyer, M (author)
Lathrop, M (author)
Nurnberger, J (author)
Steffens, M (author)
Foroud, TM (author)
Berrettini, WH (author)
Craig, DW (author)
Shi, JX (author)
Karolinska InstitutetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi (creator_code:org_t)

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By the author/editor: de Jong, S; Diniz, MJA; Saloma, A; Gadelha, A; Landén, Mikael, ...; Ota, VK; show more...; Noto, C; Curtis, C; Newhouse, SJ; Patel, H; Hall, LS; O'Reilly, PF; Belangero, SI; Adolfsson, Rolf; Breen, G; Wray, NR; Ripke, S; Mattheisen, M; Trzaskowski, M; Byrne, EM; Abdellaoui, A; Adams, MJ; Agerbo, E; Air, TM; Andlauer, TFM; Bacanu, SA; Baekvad-Hansen, ...; Beekman, ATF; Bigdeli, TB; Binder, EB; Blackwood, DHR; Bryois, J; Buttenschon, HN; Bybjerg-Grauholm ...; Cai, N; Castelao, E; Christensen, JH; Clarke, TK; Coleman, JRI; Colodro-Conde, L; Couvy-Duchesne, ...; Craddock, N; Crawford, GE; Davies, G; Deary, IJ; Degenhardt, F; Derks, EM; Direk, N; Dolan, CV; Dunn, EC; Eley, TC; Escott-Price, V; Kiadeh, FFH; Finucane, HK; Forstner, AJ; Frank, J; Gaspar, HA; Gill, M; Goes, FS; Gordon, SD; Grove, J; Hansen, CS; Hansen, TF; Herms, S; Hickie, IB; Hoffmann, P; Homuth, G; Horn, C; Hottenga, JJ; Hougaard, DM; Ising, M; Jansen, R; Jones, I; Jones, LA; Jorgenson, E; Knowles, JA; Kohane, IS; Kraft, J; Kretzschmar, WW; Krogh, J; Kutalik, Z; Li, YH; Lind, PA; MacIntyre, DJ; MacKinnon, DF; Maier, RM; Maier, W; Marchini, J; Mbarek, H; McGrath, P; McGuffin, P; Medland, SE; Mehta, D; Middeldorp, CM; Mihailov, E; Milaneschi, Y; Milani, L; Mondimore, FM; Montgomery, GW; Mostafavi, S; Mullins, N; Nauck, M; Ng, B; Nivard, MG; Nyholt, DR; Oskarsson, H; Owen, MJ; Painter, JN; Pedersen, CB; Pedersen, MG; Peterson, RE; Pettersson, E; Peyrot, WJ; Pistis, G; Posthuma, D; Quiroz, JA; Qvist, P; Rice, JP; Riley, BP; Rivera, M; Mirza, SS; Schoevers, R; Schulte, EC; Shen, L; Shyn, SI; Sigurdsson, E; Sinnamon, GCB; Smit, JH; Smith, DJ; Stefansson, H; Steinberg, S; Streit, F; Strohmaier, J; Tansey, KE; Teismann, H; Teumer, A; Thompson, W; Thomson, PA; Thorgeirsson, TE; Traylor, M; Treutlein, J; Trubetskoy, V; Uitterlinden, AG; Umbricht, D; Van der Auwera, ...; van Hemert, AM; Viktorin, A; Visscher, PM; Wang, YP; Webb, BT; Weinsheimer, SM; Wellmann, J; Willemsen, G; Witt, SH; Wu, Y; Xi, HLS; Yang, J; Zhang, FT; Arolt, V; Baune, BT; Berger, K; Boomsma, DI; Cichon, S; Dannlowski, U; de Geus, EJC; DePaulo, JR; Domenici, E; Domschke, K; Esko, T; Grabe, HJ; Hamilton, SP; Hayward, C; Heath, AC; Kendler, KS; Kloiber, S; Lewis, G; Li, QQS; Lucae, S; Madden, PAF; Magnusson, PK; Martin, NG; McIntosh, AM; Metspalu, A; Mors, O; Mortensen, PB; Muller-Myhsok, B; Nordentoft, M; Nothen, MM; O'Donovan, MC; Paciga, SA; Pedersen, NL; Penninx, BWJH; Perlis, RH; Porteous, DJ; Potash, JB; Preisig, M; Rietschel, M; Schaefer, C; Schulze, TG; Smoller, JW; Stefansson, K; Tiemeier, H; Uher, R; Volzke, H; Weissman, MM; Werge, T; Lewis, CM; Levinson, DF; Borglum, AD; Sullivan, PF; Meier, S; Strauss, J; Xu, W; Vincent, JB; Matthews, K; Ferreira, M; O'Dushlaine, C; Purcell, S; Raychaudhuri, S; Ruderfer, DM; Sklar, P; Scott, LJ; Flickinger, M; Burmeister, M; Li, J; Guan, WH; Absher, D; Thompson, RC; Meng, FG; Schatzberg, AF; Bunney, WE; Barchas, JD; Watson, SJ; Myers, RM; Akil, H; Boehnke, M; Chambert, K; Moran, J; Scolnick, E; Djurovic, S; Melle, I; Morken, G; Nordin Adolfsson ...; Anjorin, A; Kandaswamy, R; Lawrence, J; McLean, AW; Pickard, BS; Bergen, SE; Nimgaonkar, V; Landen, M; Schalling, M; Osby, U; Backlund, L; Frisen, L; Langstrom, N; Stahl, E; Dobbyn, A; Jamain, S; Etain, B; Bellivier, F; Leber, M; Maaser, A; Fischer, SB; Reinbold, CS; Kittel-Schneider ...; Fullerton, JM; Oruc, L; Para, JG; Mayoral, F; Rivas, F; Czerski, PM; Kammerer-Ciernio ...; Vedder, H; Borrmann-Hassenb ...; Pfennig, A; Brennan, P; McKay, JD; Kogevinas, M; Schwarz, M; Schofield, PR; Muhleisen, TW; Schumacher, J; Bauer, M; Wright, A; Mitchell, PB; Hautzinger, M; Kelsoe, JR; Greenwood, TA; Nievergelt, CM; Shilling, PD; Smith, EN; Bloss, CS; Edenberg, HJ; Koller, DL; Gershon, ES; Liu, CY; Badner, JA; Scheftner, WA; Lawson, WB; Nwulia, EA; Hipolito, M; Coryell, W; Rice, J; Byerley, W; McMahon, FJ; Lohoff, FW; Zandi, PP; Mahon, PB; McInnis, MG; Zollner, S; Zhang, P; Szelinger, S; St Clair, D; Caesar, S; Gordon-Smith, K; Fraser, C; Green, EK; Grozeva, D; Hamshere, ML; Kirov, G; Nikolov, I; Collier, DA; Elkin, A; Williamson, R; Young, AH; Ferrier, IN; Milanova, V; Alda, M; Cervantes, P; Cruceanu, C; Rouleau, GA; Turecki, G; Paciga, S; Winslow, AR; Grigoroiu-Serban ...; Ophoff, R; Adolfsson, R; Adolfsson, AN; Del-Favero, J; Pato, C; Biernacka, JM; Frye, MA; Morris, D; Schork, NJ; Reif, A; Lissowska, J; Hauser, J; Szeszenia-Dabrow ...; McGhee, K; Quinn, E; Moskvina, V; Holmans, PA; Farmer, A; Kennedy, JL; Andreassen, OA; Mattingsdal, M; Bass, NJ; Gurling, H; McQuillin, A; Breuer, R; Hultman, C; Lichtenstein, P; Huckins, LM; Leboyer, M; Lathrop, M; Nurnberger, J; Steffens, M; Foroud, TM; Berrettini, WH; Craig, DW; Shi, JX; show less...

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