Search: WFRF:(Bowtell D) >
Pan-cancer analysis...
Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition
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- Rodriguez-Martin, B (author)
- University of Santiago de Compostela
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- Alvarez, EG (author)
- University of Santiago de Compostela
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- Baez-Ortega, A (author)
- University of Cambridge
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show more...
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- Zamora, J (author)
- University of Santiago de Compostela
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- Supek, F (author)
- Institute for Research in Biomedicine (IRB Barcelona)
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- Demeulemeester, J (author)
- Francis Crick Institute
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- Santamarina, M (author)
- University of Santiago de Compostela
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- Ju, YS (author)
- Korea Advanced Institute of Science and Technology (KAIST)
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- Temes, J (author)
- University of Santiago de Compostela
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- Garcia-Souto, D (author)
- University of Santiago de Compostela
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- Detering, H (author)
- University of Vigo
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- Li, YL (author)
- Wellcome Trust Sanger Institute
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- Rodriguez-Castro, J (author)
- University of Santiago de Compostela
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- Dueso-Barroso, A (author)
- University of Vic
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- Bruzos, AL (author)
- University of Santiago de Compostela
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- Dentro, SC (author)
- Francis Crick Institute
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- Blanco, MG (author)
- University of Santiago de Compostela,Yale University
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- Contino, G (author)
- University of Cambridge
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- Ardeljan, D (author)
- Johns Hopkins University
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- Tojo, M (author)
- University of Vigo
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- Roberts, ND (author)
- Wellcome Trust Sanger Institute
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- Zumalave, S (author)
- University of Santiago de Compostela
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- Edwards, PAW (author)
- University of Cambridge
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- Weischenfeldt, J (author)
- European Molecular Biology Laboratory Heidelberg
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- Puiggros, M (author)
- Centro Nacional de Supercomputación
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- Chong, ZC (author)
- University of Texas
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- Chen, K (author)
- University of Texas MD Anderson Cancer Center
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- Lee, EA (author)
- Harvard Medical School
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- Wala, JA (author)
- Broad Institute
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- Raine, K (author)
- Wellcome Trust Sanger Institute
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- Butler, A (author)
- Wellcome Trust Sanger Institute
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- Waszak, SM (author)
- European Molecular Biology Laboratory Heidelberg
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- Navarro, FCP (author)
- Yale University
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- Schumacher, SE (author)
- Broad Institute
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- Monlong, J (author)
- McGill University,University of Santiago de Compostela
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- Maura, F (author)
- Wellcome Trust Sanger Institute
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- Bolli, N (author)
- University of Milan
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- Bourque, G (author)
- McGill University
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Gerstein, M (author)
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- Park, PJ (author)
- Harvard Medical School
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- Wedge, DC (author)
- Wellcome Trust Sanger Institute
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- Beroukhim, R (author)
- Broad Institute
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- Torrents, D (author)
- Catalan Institution for Research and Advanced Studies
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- Korbel, JO (author)
- European Molecular Biology Laboratory Heidelberg
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- Martincorena, I (author)
- Wellcome Trust Sanger Institute
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- Fitzgerald, RC (author)
- University of Cambridge
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- Van Loo, P (author)
- Francis Crick Institute
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- Kazazian, HH (author)
- Johns Hopkins University
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- Burns, KH (author)
- Johns Hopkins University
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- Campbell, PJ (author)
- Wellcome Trust Sanger Institute
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Tubio, JMC (author)
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Akdemir, KC (author)
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Boutros, PC (author)
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Bowtell, DDL (author)
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Brors, B (author)
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Chan, K (author)
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Cortes-Ciriano, I (author)
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Dunford, AJ (author)
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Edwards, PA (author)
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Estivill, X (author)
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Etemadmoghadam, D (author)
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Feuerbach, L (author)
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Fink, JL (author)
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Frenkel-Morgenstern, M (author)
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Garsed, DW (author)
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Gordenin, DA (author)
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Haan, D (author)
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Haber, JE (author)
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Hess, JM (author)
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Hutter, B (author)
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Imielinski, M (author)
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Jones, DTW (author)
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Kazanov, MD (author)
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Klimczak, LJ (author)
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Koh, Y (author)
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Kumar, K (author)
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Lee, JJK (author)
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Lynch, AG (author)
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Macintyre, G (author)
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Markowetz, F (author)
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Martinez-Fundichely, A (author)
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Meyerson, M (author)
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Miyano, S (author)
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Nakagawa, H (author)
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Ossowski, S (author)
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Pearson, JV (author)
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Rippe, K (author)
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Roberts, SA (author)
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Scully, R (author)
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Shackleton, M (author)
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Sidiropoulos, N (author)
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Sieverling, L (author)
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Stewart, C (author)
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Villasante, I (author)
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Waddell, N (author)
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Yang, LX (author)
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Yao, XT (author)
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Yoon, SS (author)
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Zhang, CZ (author)
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- Borg, Åke (creator_code:cre_t)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Familjär bröstcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Familial Breast Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Ringnér, Markus (creator_code:cre_t)
- Lund University,Lunds universitet,Molekylär cellbiologi,Biologiska institutionen,Naturvetenskapliga fakulteten,Molecular Cell Biology,Department of Biology,Faculty of Science
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- Staaf, Johan (creator_code:cre_t)
- Lund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Forskningsgrupp Lungcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Bröst/lungcancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine,Research Group Lung Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Breast/lungcancer,Section I,Department of Clinical Sciences, Lund
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(creator_code:org_t)
- 2020-02-05
- 2020
- English.
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In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 52:3, s. 306-
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http://dx.doi.org/10... (free)
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Abstract
Subject headings
Close
- About half of all cancers have somatic integrations of retrotransposons. Here, to characterize their role in oncogenesis, we analyzed the patterns and mechanisms of somatic retrotransposition in 2,954 cancer genomes from 38 histological cancer subtypes within the framework of the Pan-Cancer Analysis of Whole Genomes (PCAWG) project. We identified 19,166 somatically acquired retrotransposition events, which affected 35% of samples and spanned a range of event types. Long interspersed nuclear element (LINE-1; L1 hereafter) insertions emerged as the first most frequent type of somatic structural variation in esophageal adenocarcinoma, and the second most frequent in head-and-neck and colorectal cancers. Aberrant L1 integrations can delete megabase-scale regions of a chromosome, which sometimes leads to the removal of tumor-suppressor genes, and can induce complex translocations and large-scale duplications. Somatic retrotranspositions can also initiate breakage–fusion–bridge cycles, leading to high-level amplification of oncogenes. These observations illuminate a relevant role of 22 L1 retrotransposition in remodeling the cancer genome, with potential implications for the development of human tumors.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- Carcinogenesis/genetics
- Gene Rearrangement/genetics
- Genome, Human/genetics
- Humans
- Long Interspersed Nucleotide Elements/genetics
- Neoplasms/genetics
- Retroelements/genetics
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Rodriguez-Martin ...
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Alvarez, EG
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Baez-Ortega, A
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Zamora, J
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Supek, F
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Demeulemeester, ...
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show more...
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Santamarina, M
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Ju, YS
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Temes, J
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Garcia-Souto, D
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Detering, H
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Li, YL
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Rodriguez-Castro ...
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Dueso-Barroso, A
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Bruzos, AL
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Dentro, SC
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Blanco, MG
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Contino, G
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Ardeljan, D
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Tojo, M
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Roberts, ND
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Zumalave, S
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Edwards, PAW
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Weischenfeldt, J
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Puiggros, M
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Chong, ZC
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Chen, K
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Lee, EA
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Wala, JA
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Raine, K
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Butler, A
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Waszak, SM
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Navarro, FCP
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Schumacher, SE
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Monlong, J
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Maura, F
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Bolli, N
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Bourque, G
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Gerstein, M
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Park, PJ
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Wedge, DC
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Beroukhim, R
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Torrents, D
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Korbel, JO
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Martincorena, I
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Fitzgerald, RC
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Van Loo, P
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Kazazian, HH
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Burns, KH
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Campbell, PJ
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Tubio, JMC
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Akdemir, KC
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Boutros, PC
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Bowtell, DDL
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Brors, B
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Chan, K
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Cortes-Ciriano, ...
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Dunford, AJ
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Edwards, PA
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Estivill, X
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Etemadmoghadam, ...
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Feuerbach, L
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Fink, JL
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Frenkel-Morgenst ...
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Garsed, DW
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Gordenin, DA
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Haan, D
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Haber, JE
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Hess, JM
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Hutter, B
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Imielinski, M
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Jones, DTW
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Kazanov, MD
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Klimczak, LJ
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Koh, Y
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Kumar, K
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Lee, JJK
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Lynch, AG
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Macintyre, G
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Markowetz, F
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Martinez-Fundich ...
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Meyerson, M
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Miyano, S
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Nakagawa, H
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Ossowski, S
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Pearson, JV
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Rippe, K
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Roberts, SA
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Scully, R
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Shackleton, M
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Sidiropoulos, N
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Sieverling, L
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Stewart, C
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Villasante, I
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Waddell, N
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Yang, LX
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Yao, XT
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Yoon, SS
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Zhang, CZ
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Borg, Åke
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Ringnér, Markus
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Staaf, Johan
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Nature genetics
- By the university
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Karolinska Institutet
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Lund University