Search: WFRF:(Morris AP) >
Genome-wide associa...
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Shah, SUniv Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia;UCL, Inst Cardiovasc Sci, London, England;UCL, British Heart Fdn Res Accelerator, London, England,Univ Dundee, Ninewells Hosp & Med Sch, Div Mol & Clin Med, Dundee DD1 9SY, Scotland,Univ Maryland, Sch Med, Dept Med, Div Cardiol, Baltimore, MD 21201 USA,NHLBI, Framingham, MA USA;Boston Univ Framingham Heart Study, Framingham, MA USA;Boston Univ, Sch Med, Dept Med, Sect Cardiol, Boston, MA 02118 USA;Boston Univ, Sch Med, Dept Med, Sect Prevent Med, Boston, MA 02118 USA;Boston Univ, Sch Med, Dept Med, Sect Epidemiol, Boston, MA 02118 USA;Boston Univ, Sch Publ Hlth, Dept Med, Sect Cardiol, Boston, MA USA;Boston Univ, Sch Publ Hlth, Dept Med, Sect Prevent Med, Boston, MA USA;Boston Univ, Sch Publ Hlth, Dept Med, Sect Epidemiol, Boston, MA USA,University College London,University of Queensland
(author)
Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure
- Article/chapterEnglish2020
Publisher, publication year, extent ...
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2020-01-09
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Springer Science and Business Media LLC,2020
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:143042168
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http://kipublications.ki.se/Default.aspx?queryparsed=id:143042168URI
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https://doi.org/10.1038/s41467-019-13690-5DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-407649URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:du-31615URI
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https://lup.lub.lu.se/record/53a12482-9dd1-4daa-aa64-79a288cf3ce3URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only limited insights, leaving the observed heritability of HF largely unexplained. We report results from a GWAS meta-analysis of HF comprising 47,309 cases and 930,014 controls. Twelve independent variants at 11 genomic loci are associated with HF, all of which demonstrate one or more associations with coronary artery disease (CAD), atrial fibrillation, or reduced left ventricular function, suggesting shared genetic aetiology. Functional analysis of non-CAD-associated loci implicate genes involved in cardiac development (MYOZ1, SYNPO2L), protein homoeostasis (BAG3), and cellular senescence (CDKN1A). Mendelian randomisation analysis supports causal roles for several HF risk factors, and demonstrates CAD-independent effects for atrial fibrillation, body mass index, and hypertension. These findings extend our knowledge of the pathways underlying HF and may inform new therapeutic strategies.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Henry, AUCL, Inst Cardiovasc Sci, London, England;UCL, British Heart Fdn Res Accelerator, London, England;UCL, Inst Hlth Informat, London, England
(author)
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Roselli, CBroad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA USA;Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands
(author)
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Lin, HHBoston Univ, Sch Med, Dept Med, Sect Computat Biomed, Boston, MA 02118 USA;NHLBI, Framingham, MA USA;Boston Univ Framingham Heart Study, Framingham, MA USA,Emory Univ, Dept Med, Med Ctr, Div Cardiol, Atlanta, GA 30322 USA,Pfizer Worldwide Res & Dev, 1 Portland St, Cambridge, MA USA,UCL, British Heart Fdn Res Accelerator, London, England;UCL, Inst Hlth Informat, London, England;UCL, Hlth Data Res UK London, London, England;Univ Glasgow, BHF Cardiovasc Res Ctr, Glasgow, Lanark, Scotland,Amgen Inc, deCODE Genet, Sturlugata 8, IS-101 Reykjavik, Iceland
(author)
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Sveinbjornsson, GAmgen Inc, deCODE Genet, Sturlugata 8, IS-101 Reykjavik, Iceland
(author)
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Fatemifar, GUCL, British Heart Fdn Res Accelerator, London, England;UCL, Inst Hlth Informat, London, England;UCL, Hlth Data Res UK London, London, England,Amgen Inc, deCODE Genet, Sturlugata 8, IS-101 Reykjavik, Iceland;Univ Iceland, Sch Engn & Nat Sci, IS-101 Reykjavik, Iceland
(author)
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Hedman, AKKarolinska Institutet,Karolinska Inst, Dept Med Solna, Cardiovasc Med Unit, Stockholm, Sweden,Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England;Glenfield Hosp, NIHR Leicester Biomed Res Ctr, Leicester, Leics, England,UCL, Div Psychiat, London W1T 7NF, England;UCL, Genet Inst, London WC1E 6BT, England
(author)
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Wilk, JBPfizer Worldwide Res & Dev, 1 Portland St, Cambridge, MA USA,Univ Penn, Perelman Sch Med, Penn Cardiovasc Inst, Philadelphia, PA 19104 USA,Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
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Morley, MPKarolinska Institutet
(author)
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Chaffin, MDBroad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA USA,Univ Med Greifswald, Dept Internal Med B, Greifswald, Germany;DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany
(author)
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Helgadottir, AAmgen Inc, deCODE Genet, Sturlugata 8, IS-101 Reykjavik, Iceland
(author)
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Verweij, NBroad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA USA;Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands
(author)
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Dehghan, AImperial Coll London, Dept Epidemiol & Biostat, St Marys Campus, London W2 1PG, England;Imperial Coll London, Dept Epidemiol & Biostat, MRC PHE Ctr Environm & Hlth, St Marys Campus, London W2 1PG, England,Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland,UCL, Inst Cardiovasc Sci, London, England;UCL, British Heart Fdn Res Accelerator, London, England
(author)
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Almgren, PeterLund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Kardiovaskulär forskning - hypertoni,Diabetes - Cardiovascular Disease,Lund University Research Groups,Cardiovascular Research - Hypertension(Swepub:lu)endo-pal
(author)
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Andersson, CNHLBI, Framingham, MA USA;Boston Univ Framingham Heart Study, Framingham, MA USA;Herlev Gentofte Hosp, Dept Cardiol, Herlev Ringvej 57, DK-2650 Herlev, Denmark
(author)
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Aragam, KGBroad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA USA;Massachusetts Gen Hosp, Ctr Genom Med, Boston, MA 02114 USA;Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA
(author)
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Ärnlöv, Johan,1970-Högskolan Dalarna,Karolinska Institutet,Karolinska Inst, Sect Family Med & Primary Care, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden;Dalarna Univ, Sch Hlth & Social Sci, Falun, Sweden,Medicinsk vetenskap,Karolinska institutet(Swepub:du)jan
(author)
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Backman, JDRegeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
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Lind, LarsUppsala universitet,Klinisk epidemiologi,Brigham & Womens Hosp, Div Cardiovasc, TIMI Study Grp, 75 Francis St, Boston, MA 02115 USA,Kaiser Permanente Washington, Kaiser Permanente Washington Hlth Res Inst, Seattle, WA USA;Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA;Dept Vet Affairs Off Res & Dev, Seattle Epidemiol Res & Informat Ctr, Seattle, WA USA(Swepub:uu)larslind
(author)
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Bloom, HLRegeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
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Brandimarto, JRegeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
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Brown, MRUniv Texas Sch Publ Hlth, Dept Epidemiol Human Genet & Environm Sci, Houston, TX USA
(author)
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Buckbinder, LPfizer Worldwide Res & Dev, 1 Portland St, Cambridge, MA USA
(author)
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Carey, DJGeisinger, Dept Mol & Funct Genom, Danville, PA USA
(author)
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Chasman, DIBrigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA;Harvard Med Sch, Boston, MA 02115 USA
(author)
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Chen, XPfizer Worldwide Res & Dev, 1 Portland St, Cambridge, MA USA,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
(author)
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Chen, X
(author)
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Chung, JRegeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
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Chutkow, WNovartis Inst Biomed Res, Cambridge, MA USA
(author)
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Cook, JPUniv Liverpool, Dept Biostat, Liverpool, Merseyside, England,Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
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Engström, GunnarLund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups(Swepub:lu)smi-gen
(author)
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Denaxas, SUCL, British Heart Fdn Res Accelerator, London, England;UCL, Inst Hlth Informat, London, England;UCL, Hlth Data Res UK London, London, England;UCL, Natl Inst Hlth Res, Hosp Biomed Res Ctr, London, England;Alan Turing Inst, London, England,Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
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Doney, ASCopenhagen Univ Hosp, Dept Clin Biochem, Copenhagen, Denmark,Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
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Dorr, M
(author)
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Dudley, SCUniv Minnesota, Dept Med, Cardiovasc Div, Minneapolis, MN USA,Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
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Dunn, MERegeneron Pharmaceut, Cardiovasc Res, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
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Engstrom, G
(author)
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Esko, TBroad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA USA;Univ Tartu, Inst Genom, Estonian Genome Ctr, EE-51010 Tartu, Estonia
(author)
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Felix, SBUniv Med Greifswald, Dept Internal Med B, Greifswald, Germany;DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany,Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
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Finan, CUCL, Inst Cardiovasc Sci, London, England;UCL, British Heart Fdn Res Accelerator, London, England
(author)
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Ford, IUniv Glasgow, Robertson Ctr Biostat, Glasgow, Lanark, Scotland
(author)
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Ghanbari, MErasmus Univ, Med Ctr, Dept Epidemiol, Rotterdam, Netherlands
(author)
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Ghasemi, SDZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany;Univ Med Greifswald, Inst Community Med, Greifswald, Germany
(author)
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Giedraitis, VilmantasUppsala universitet,Geriatrik(Swepub:uu)vigie517
(author)
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Giulianini, FBrigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA
(author)
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Gottdiener, JS
(author)
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Gross, SUniv Med Greifswald, Dept Internal Med B, Greifswald, Germany;DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany
(author)
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Gudbjartsson, DFRegeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
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Gutmann, RUniv Iowa, Carver Coll Med, Div Cardiovasc Med, Iowa City, IA USA,Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
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Haggerty, CMGeisinger, Dept Mol & Funct Genom, Danville, PA USA,Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
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van der Harst, PUniv Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands;Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands;ICIN Netherlands Heart Inst, Durrer Ctr Cardiogenet Res, Utrecht, Netherlands
(author)
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Hyde, CLUniv Cambridge, Sch Clin Med, Inst Metab Sci, MRC Epidemiol Unit, Cambridge CB2 0QQ, England
(author)
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Ingelsson, Erik,1975-Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi,Stanford Univ, Sch Med, Div Cardiovasc Med, Dept Med, Stanford, CA 94305 USA;Stanford Univ, Stanford Cardiovasc Inst, Stanford, CA 94305 USA;Stanford Univ, Stanford Diabet Res Ctr, Stanford, CA 94305 USA(Swepub:uu)ering425
(author)
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Jukema, JWLeiden Univ, Med Ctr, Dept Cardiol, Leiden, Netherlands;LUMC, Einthoven Lab Expt Vasc Med, Leiden, Netherlands,Univ Cambridge, Sch Clin Med, Inst Metab Sci, MRC Epidemiol Unit, Cambridge CB2 0QQ, England
(author)
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Kavousi, MErasmus Univ, Med Ctr, Dept Epidemiol, Rotterdam, Netherlands,Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
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Khaw, KTUniv Cambridge, Dept Publ Hlth & Primary Care, Cambridge CB2 0QQ, England,Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
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Kleber, MEHeidelberg Univ, Med Fac Mannheim, Dept Med Nephrol Hypertensiol Endocrinol Diabetol, Heidelberg, Germany
(author)
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Kober, LCopenhagen Univ Hosp, Rigshosp, Dept Cardiol, Copenhagen, Denmark
(author)
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Koekemoer, A
(author)
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Langenberg, C
(author)
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Lind, LRegeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
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Lindgren, CMBroad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA USA;Univ Oxford, Li Ka Shing Ctr Hlth Informat & Discovery, Big Data Inst, Oxford, England;Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England
(author)
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London, BUniv Iowa, Div Cardiovasc Med, Iowa City, IA USA;Univ Iowa, Abboud Cardiovasc Res Ctr, Iowa City, IA USA
(author)
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Lotta, LAUniv Cambridge, Sch Clin Med, Inst Metab Sci, MRC Epidemiol Unit, Cambridge CB2 0QQ, England,Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
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Lovering, RCUCL, Inst Cardiovasc Sci, London, England;UCL, British Heart Fdn Res Accelerator, London, England
(author)
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Luan, JAUniv Cambridge, Sch Clin Med, Inst Metab Sci, MRC Epidemiol Unit, Cambridge CB2 0QQ, England
(author)
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Magnusson, PKarolinska Institutet
(author)
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Mahajan, AUniv Oxford, Wellcome Trust Ctr Human Genet, Oxford, England,GlaxoSmithKline, Human Genet, Collegeville, PA USA
(author)
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Margulies, KBUniv Penn, Perelman Sch Med, Penn Cardiovasc Inst, Philadelphia, PA 19104 USA
(author)
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Marz, WUniv Liverpool, Dept Biostat, Liverpool, Merseyside, England;Synlab Holding Deutschland GmbH, Synlab Acad, Mannheim, Germany;Med Univ Graz, Clin Inst Med & Chem Lab Diagnost, Graz, Austria
(author)
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Melander, OlleLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)endo-ome
(author)
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Mordi, IRUniv Dundee, Ninewells Hosp & Med Sch, Div Mol & Clin Med, Dundee DD1 9SY, Scotland
(author)
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Morgan, TNovartis Inst Biomed Res, Cambridge, MA USA;Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA
(author)
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Morris, ADRegeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
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Morris, APUniv Liverpool, Dept Biostat, Liverpool, Merseyside, England;Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England
(author)
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Morrison, ACUniv Texas Sch Publ Hlth, Dept Epidemiol Human Genet & Environm Sci, Houston, TX USA
(author)
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Nagle, MWPfizer Worldwide Res & Dev, 1 Portland St, Cambridge, MA USA
(author)
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Nelson, CPUniv Leicester, Dept Cardiovasc Sci, Leicester, Leics, England;Glenfield Hosp, NIHR Leicester Biomed Res Ctr, Leicester, Leics, England,Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
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Niessner, AMed Univ Vienna, Div Cardiol, Dept Internal Med 2, Vienna, Austria
(author)
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Niiranen, TNatl Inst Hlth & Welf, Helsinki, Finland;Turku Univ Hosp, Dept Med, Turku, Finland;Univ Turku, Turku, Finland
(author)
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O'Donoghue, MLRegeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
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Owens, ATUniv Penn, Perelman Sch Med, Penn Cardiovasc Inst, Philadelphia, PA 19104 USA,DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany;Univ Med Greifswald, Inst Community Med, Greifswald, Germany
(author)
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Palmer, CNABroad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA USA;Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA;Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA
(author)
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Parry, HM
(author)
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Perola, M
(author)
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Portilla-Fernandez, EErasmus Univ, Med Ctr, Dept Epidemiol, Rotterdam, Netherlands;Erasmus MC, Dept Internal Med, Div Vasc Med & Pharmacol, Rotterdam, Netherlands
(author)
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Psaty, BM
(author)
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Rice, KMUniv Washington, Dept Biostat, Seattle, WA 98195 USA,Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
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Ridker, PM
(author)
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Romaine, SPRKarolinska Institutet
(author)
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Rotter, JIHarbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Inst Translat Genom & Populat Sci, Dept Pediat, Torrance, CA 90509 USA;Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Inst Translat Genom & Populat Sci, Dept Med, Torrance, CA 90509 USA
(author)
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Salo, P
(author)
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Salomaa, VNatl Inst Hlth & Welf, Helsinki, Finland
(author)
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van Setten, JUniv Utrecht, Univ Med Ctr Utrecht, Div Heart & Lungs, Dept Cardiol, Utrecht, Netherlands
(author)
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Shalaby, AAUniv Pittsburgh, Med Ctr, Dept Med, Div Cardiol, Pittsburgh, PA USA;VA Pittsburgh HCS, Pittsburgh, VA USA
(author)
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Smelser, DTGeisinger, Dept Mol & Funct Genom, Danville, PA USA
(author)
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Smith, NL
(author)
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Stender, S
(author)
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Stott, DJUniv Glasgow, Coll Med Vet & Life Sci, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland
(author)
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Svensson, PKarolinska Institutet
(author)
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Tammesoo, MLUniv Tartu, Inst Genom, Estonian Genome Ctr, EE-51010 Tartu, Estonia
(author)
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Taylor, KDHarbor UCLA Med Ctr, LABiomed, Inst Translat Genom & Populat Sci, Torrance, CA 90502 USA;Harbor UCLA Med Ctr, Dept Pediat, Torrance, CA 90502 USA
(author)
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Teder-Laving, MUniv Tartu, Inst Genom, Estonian Genome Ctr, EE-51010 Tartu, Estonia
(author)
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Teumer, A
(author)
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Thorgeirsson, GAmgen Inc, deCODE Genet, Sturlugata 8, IS-101 Reykjavik, Iceland;Natl Univ Hosp Iceland, Landspitali, Dept Internal Med, Div Cardiol, IS-101 Reykjavik, Iceland
(author)
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Thorsteinsdottir, UAmgen Inc, deCODE Genet, Sturlugata 8, IS-101 Reykjavik, Iceland;Univ Iceland, Dept Med, Fac Med, Saemundargata 2, IS-101 Reykjavik, Iceland
(author)
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Torp-Pedersen, CAalborg Univ Hosp, Dept Epidemiol & Biostat, Aalborg, Denmark;Aalborg Univ Hosp, Dept Hlth Sci & Technol, Aalborg, Denmark;Aalborg Univ Hosp, Dept Cardiol, Aalborg, Denmark
(author)
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Trompet, SLeiden Univ, Med Ctr, Dept Cardiol, Leiden, Netherlands;Leiden Univ, Med Ctr, Dept Internal Med, Sect Gerontol & Geriatr, Leiden, Netherlands
(author)
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Tyl, BServier Cardiovasc Ctr Therapeut Innovat, Translat & Clin Res, 50 Rue Carnot, F-92284 Suresnes, France
(author)
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Uitterlinden, AGErasmus Univ, Med Ctr, Dept Epidemiol, Rotterdam, Netherlands;Erasmus MC, Univ Med Ctr Rotterdam, Dept Internal Med, Rotterdam, Netherlands,Regeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
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Veluchamy, AUniv Dundee, Ninewells Hosp & Med Sch, Div Mol & Clin Med, Dundee DD1 9SY, Scotland
(author)
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Volker, UDZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany;Univ Med Greifswald, Interfac Inst Genet & Funct Genom, Greifswald, Germany
(author)
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Voors, AABoston Univ, Sch Med, Dept Med, Sect Computat Biomed, Boston, MA 02118 USA
(author)
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Wang, XSNovartis Inst Biomed Res, Cambridge, MA USA
(author)
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Wareham, NJ
(author)
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Waterworth, DGlaxoSmithKline, Human Genet, Collegeville, PA USA
(author)
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Weeke, PECopenhagen Univ Hosp, Rigshosp, Dept Cardiol, Copenhagen, Denmark
(author)
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Weiss, ROhio State Univ, Med Ctr, Dept Internal Med, Div Cardiovasc Med, Columbus, OH 43210 USA
(author)
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Wiggins, KL
(author)
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Xing, HMNovartis Inst Biomed Res, Cambridge, MA USA
(author)
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Yerges-Armstrong, LMKarolinska Institutet
(author)
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Yu, BUniv Texas Sch Publ Hlth, Dept Epidemiol Human Genet & Environm Sci, Houston, TX USA
(author)
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Zannad, FUniv Lorraine, CHU Nancy, INSERM, F-54500 Nancy, France;Inst Lorrain Coeur & Vaisseaux, INI CRCT F CRIN, F-54500 Nancy, France
(author)
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Zhao, JHUniv Cambridge, Sch Clin Med, Inst Metab Sci, MRC Epidemiol Unit, Cambridge CB2 0QQ, England
(author)
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Hemingway, HRegeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
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Samani, NJUniv Leicester, Dept Cardiovasc Sci, Leicester, Leics, England;Glenfield Hosp, NIHR Leicester Biomed Res Ctr, Leicester, Leics, England
(author)
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McMurray, JJVUniv Glasgow, BHF Cardiovasc Res Ctr, Glasgow, Lanark, Scotland
(author)
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Yang, JUniv Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia;Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia
(author)
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Visscher, PM
(author)
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Newton-Cheh, C
(author)
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Malarstig, AKarolinska Institutet,Karolinska Inst, Dept Med Solna, Cardiovasc Med Unit, Stockholm, Sweden;Pfizer Worldwide Res & Dev, 1 Portland St, Cambridge, MA USA
(author)
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Holm, H
(author)
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Lubitz, SABroad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA USA;Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA;Massachusetts Gen Hosp, Cardiac Arrhythmia Serv, Boston, MA 02114 USA
(author)
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Sattar, NUniv Glasgow, BHF Cardiovasc Res Ctr, Glasgow, Lanark, Scotland
(author)
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Holmes, MVUniv Oxford, Med Res Council, Populat Hlth Res Unit, Oxford, England;Univ Oxford, Big Data Inst, Nuffield Dept Populat Hlth, Clin Trial Serv Unit, Oxford, England;Univ Oxford, Big Data Inst, Nuffield Dept Populat Hlth, Epidemiol Studies Unit, Oxford, England;Oxford Univ Hosp, Oxford Biomed Res Ctr, Natl Inst Hlth Res, Oxford, England
(author)
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Cappola, TPUniv Penn, Perelman Sch Med, Penn Cardiovasc Inst, Philadelphia, PA 19104 USA
(author)
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Asselbergs, FWUCL, Inst Cardiovasc Sci, London, England;UCL, British Heart Fdn Res Accelerator, London, England;Univ Utrecht, Univ Med Ctr Utrecht, Div Heart & Lungs, Dept Cardiol, Utrecht, Netherlands
(author)
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Hingorani, AD
(author)
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Kuchenbaecker, K
(author)
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Ellinor, PTBroad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA USA;Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA;Massachusetts Gen Hosp, Cardiac Arrhythmia Serv, Boston, MA 02114 USA
(author)
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Lang, CCUniv Dundee, Ninewells Hosp & Med Sch, Div Mol & Clin Med, Dundee DD1 9SY, Scotland
(author)
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Stefansson, KAmgen Inc, deCODE Genet, Sturlugata 8, IS-101 Reykjavik, Iceland;Univ Iceland, Dept Med, Fac Med, Saemundargata 2, IS-101 Reykjavik, Iceland
(author)
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Smith, GustavLund University,Lunds universitet,Molecular Epidemiology and Cardiology,Forskargrupper vid Lunds universitet,Cardiovascular Epigenetics,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine(Swepub:lu)med-gvs
(author)
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Vasan, RS
(author)
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Swerdlow, DIUCL, Inst Cardiovasc Sci, London, England
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Lumbers, RTUCL, British Heart Fdn Res Accelerator, London, England;UCL, Inst Hlth Informat, London, England;UCL, Hlth Data Res UK London, London, England;St Bartholomews Hosp, Barts Heart Ctr, London, England,Barts Health NHS Trust,University College London
(author)
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Abecasis, G
(author)
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Backman, J
(author)
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Bai, XDRegeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
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Balasubramanian, S
(author)
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Banerjee, NRegeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
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Baras, ARegeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
-
Barnard, LRegeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
-
Beechert, CRegeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
-
Blumenfeld, ARegeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
-
Cantor, M
(author)
-
Chai, YTRegeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
-
Chung, J
(author)
-
Coppola, GRegeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
-
Damask, A
(author)
-
Dewey, FRegeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
-
Economides, ARegeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
-
Eom, G
(author)
-
Forsythe, CRegeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
-
Fuller, ED
(author)
-
Gu, ZHRegeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
-
Gurski, LRegeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
-
Guzzardo, PM
(author)
-
Habegger, L
(author)
-
Hahn, YRegeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
-
Hawes, ARegeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
-
van Hout, CRegeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
-
Jones, MB
(author)
-
Khalid, SRegeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
-
Lattari, M
(author)
-
Li, A
(author)
-
Lin, N
(author)
-
Liu, DRRegeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
-
Lopez, A
(author)
-
Manoochehri, K
(author)
-
Marchini, JRegeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
-
Marcketta, ARegeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
-
Maxwell, EK
(author)
-
McCarthy, SRegeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
-
Mitnaul, LJRegeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
-
O'Dushlaine, CRegeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
-
Overton, JDRegeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
-
Padilla, MSRegeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
-
Paulding, C
(author)
-
Penn, J
(author)
-
Pradhan, M
(author)
-
Reid, JG
(author)
-
Schleicher, TD
(author)
-
Schurmann, C
(author)
-
Shuldiner, A
(author)
-
Staples, JC
(author)
-
Sun, DRegeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
-
Toledo, K
(author)
-
Ulloa, RH
(author)
-
Widom, LRegeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
-
Wolf, SERegeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
-
Yadav, ARegeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
-
Ye, BRegeneron Genet Ctr, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
(author)
-
Center, Regeneron Genetics
(author)
-
Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia;UCL, Inst Cardiovasc Sci, London, England;UCL, British Heart Fdn Res Accelerator, London, EnglandUniv Dundee, Ninewells Hosp & Med Sch, Div Mol & Clin Med, Dundee DD1 9SY, Scotland
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et al.
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In:Nature communications: Springer Science and Business Media LLC11:1, s. 163-2041-1723
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