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  • Rovira, PPsychiatric Genetics Unit, Group of Psychiatry, Mental Health, and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain; Department of Psychiatry, Hospital Universitari Vall d'Hebron, Barcelona, Catalonia, Spain (author)

Shared genetic background between children and adults with attention deficit/hyperactivity disorder

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • 2020-04-12
  • Springer Science and Business Media LLC,2020

Numbers

  • LIBRIS-ID:oai:prod.swepub.kib.ki.se:143482412
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:143482412URI
  • https://doi.org/10.1038/s41386-020-0664-5DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-81191URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Attention deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder characterized by age-inappropriate symptoms of inattention, impulsivity, and hyperactivity that persist into adulthood in the majority of the diagnosed children. Despite several risk factors during childhood predicting the persistence of ADHD symptoms into adulthood, the genetic architecture underlying the trajectory of ADHD over time is still unclear. We set out to study the contribution of common genetic variants to the risk for ADHD across the lifespan by conducting meta-analyses of genome-wide association studies on persistent ADHD in adults and ADHD in childhood separately and jointly, and by comparing the genetic background between them in a total sample of 17,149 cases and 32,411 controls. Our results show nine new independent loci and support a shared contribution of common genetic variants to ADHD in children and adults. No subgroup heterogeneity was observed among children, while this group consists of future remitting and persistent individuals. We report similar patterns of genetic correlation of ADHD with other ADHD-related datasets and different traits and disorders among adults, children, and when combining both groups. These findings confirm that persistent ADHD in adults is a neurodevelopmental disorder and extend the existing hypothesis of a shared genetic architecture underlying ADHD and different traits to a lifespan perspective.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Demontis, D (author)
  • Sanchez-Mora, C (author)
  • Zayats, T (author)
  • Klein, M (author)
  • Mota, NRPsychiatric Genetics Unit, Group of Psychiatry, Mental Health, and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain; Department of Psychiatry, Hospital Universitari Vall d'Hebron, Barcelona, Catalonia, Spain; Biomedical Network Research Centre on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Genetics, Microbiology, and Statistics, Faculty of Biology, University of Barcelona, Barcelona, Catalonia, Spain (author)
  • Weber, H (author)
  • Garcia-Martinez, I (author)
  • Pagerols, M (author)
  • Vilar-Ribo, L (author)
  • Arribas, L (author)
  • Richarte, V (author)
  • Corrales, M (author)
  • Fadeuilhe, C (author)
  • Bosch, R (author)
  • Martin, GE (author)
  • Almos, P (author)
  • Doyle, AE (author)
  • Grevet, EH (author)
  • Grimm, O (author)
  • Halmoy, A (author)
  • Hoogman, M (author)
  • Hutz, M (author)
  • Jacob, CP (author)
  • Kittel-Schneider, S (author)
  • Knappskog, PM (author)
  • Lundervold, AJ (author)
  • Rivero, O (author)
  • Rovaris, DL (author)
  • Salatino-Oliveira, A (author)
  • da Silva, BS (author)
  • Svirin, E (author)
  • Sprooten, E (author)
  • Strekalova, T (author)
  • Arias-Vasquez, A (author)
  • Sonuga-Barke, EJS (author)
  • Asherson, P (author)
  • Bau, CHD (author)
  • Buitelaar, JK (author)
  • Cormand, B (author)
  • Faraone, SV (author)
  • Haavik, J (author)
  • Johansson, SE (author)
  • Kuntsi, J (author)
  • Larsson, Henrik,1975-Örebro universitet,Karolinska Institutet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SwedenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden(Swepub:oru)hiln (author)
  • Lesch, KP (author)
  • Reif, A (author)
  • Rohde, LA (author)
  • Casas, M (author)
  • Borglum, AD (author)
  • Franke, B (author)
  • Ramos-Quiroga, JA (author)
  • Artigas, MS (author)
  • Ribases, M (author)
  • Psychiatric Genetics Unit, Group of Psychiatry, Mental Health, and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain; Department of Psychiatry, Hospital Universitari Vall d'Hebron, Barcelona, Catalonia, SpainPsychiatric Genetics Unit, Group of Psychiatry, Mental Health, and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain; Department of Psychiatry, Hospital Universitari Vall d'Hebron, Barcelona, Catalonia, Spain; Biomedical Network Research Centre on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Genetics, Microbiology, and Statistics, Faculty of Biology, University of Barcelona, Barcelona, Catalonia, Spain (creator_code:org_t)

Related titles

  • In:Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology: Springer Science and Business Media LLC45:10, s. 1617-16261740-634X0893-133X
  • In:Neuropsychopharmacology: Springer Science and Business Media LLC45:10, s. 1617-16260893-133X

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