Assessing TEG6S reliability between devices and across multiple time points: A prospective thromboelastography validation study

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Lloyd-Donald, P (författare)

Assessing TEG6S reliability between devices and across multiple time points: A prospective thromboelastography validation study

Artikel/kapitelEngelska2020

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2020-04-27
Springer Science and Business Media LLC,2020

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LIBRIS-ID:oai:prod.swepub.kib.ki.se:143639136
http://kipublications.ki.se/Default.aspx?queryparsed=id:143639136URI
https://doi.org/10.1038/s41598-020-63964-yDOI

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Språk:engelska
Sammanfattning på:engelska

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The TEG6S is a novel haemostasis analyser utilising resonance technology. It offers potentially greater coagulation information and ease of use, however has not been independently validated in a clinical setting. We aimed to determine if the TEG6S is reliable between devices and across time points. We performed a prospective observational study with ethical approval. For interdevice reliability, we performed simultaneous analysis on two TEG6S devices on 25 adult ICU patients. For time point reliability, we performed repeated sampling across five different time points on 15 adult participants. Blood was collected with informed consent, or as standard care, before four-channel citrated kaolin analysis. We observed almost perfect interdevice reliability across all TEG parameters. The Lin’s concordance correlation coefficients (95% CI, major axis regression slope, intercept) were R-time: 0.96 (0.92–0.99, 0.88, 0.57); K-time: 0.93 (0.87–0.98, 1.07, 0.00); Alpha Angle: 0.87 (0.78–0.96, 1.20, −14.10); Maximum Amplitude: 0.99 (0.98–0.99, 1.02, −1.38); Clot Lysis: 0.89 (0.82–0.97, 1.20, 0.07). Additionally, we observed moderate-to-high reliability across time points. Demonstrating almost perfect agreement across different devices and moderate-to-high reliability across multiple time points, suggests the TEG6S platform can be used with haemostatic accuracy and generalisability. This has potentially significant implications for clinical practice and multi-site research programs.

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Churilov, L (författare)
Cheong, B (författare)
Bellomo, R (författare)
McCall, PR (författare)
Martensson, JKarolinska Institutet (författare)
Glassford, N (författare)
Weinberg, L (författare)
Karolinska Institutet (creator_code:org_t)

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Ingår i:Scientific reports: Springer Science and Business Media LLC10:1, s. 7045-2045-2322

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Av författaren/redakt...: Lloyd-Donald, P; Churilov, L; Cheong, B; Bellomo, R; McCall, PR; Martensson, J; visa fler...; Glassford, N; Weinberg, L; visa färre...

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Av lärosätet: Karolinska Institutet

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