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- Healy, K (author)
Chronic Viral Liver Diseases: Approaching the Liver Using T Cell Receptor-Mediated Gene Technologies
- Article/chapterEnglish2020
Publisher, publication year, extent ...
- 2020-06-16
- MDPI AG,2020
Numbers
- LIBRIS-ID:oai:prod.swepub.kib.ki.se:144208592
- http://kipublications.ki.se/Default.aspx?queryparsed=id:144208592URI
- https://doi.org/10.3390/cells9061471DOI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- Chronic infection with viral hepatitis is a major risk factor for liver injury and hepatocellular carcinoma (HCC). One major contributing factor to the chronicity is the dysfunction of virus-specific T cell immunity. T cells engineered to express virus-specific T cell receptors (TCRs) may be a therapeutic option to improve host antiviral responses and have demonstrated clinical success against virus-associated tumours. This review aims to give an overview of TCRs identified from viral hepatitis research and discuss how translational lessons learned from cancer immunotherapy can be applied to the field. TCR isolation pipelines, liver homing signals, cell type options, as well as safety considerations will be discussed herein.
Added entries (persons, corporate bodies, meetings, titles ...)
- Pasetto, AKarolinska Institutet (author)
- Sobkowiak, MJKarolinska Institutet (author)
- Soon, CF (author)
- Cornberg, M (author)
- Aleman, SKarolinska Institutet (author)
- Chen, MSKarolinska Institutet (author)
- Karolinska Institutet (creator_code:org_t)
Related titles
- In:Cells: MDPI AG9:62073-4409
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